129306-07-6

Basic information

• Product Name: 7-Amino-5-benzyl-5-azaspiro[2.4]heptane
• Synonyms: 7-Amino-5-benzyl-5-azaspiro[2.4]heptane;5-(phenylMethyl)-5-Azaspiro[2.4]heptan-7-aMine;5-benzyl-5-azaspiro[2.4]heptan-7-amine
• CAS NO: 129306-07-6
• Molecular Formula: C₁₃H₁₈N₂
• Molecular Weight: 202.3
• Product Categories: pharmacetical
• Mol File: 129306-07-6.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 7-Amino-5-benzyl-5-azaspiro[2.4]heptane(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Amino-5-benzyl-5-azaspiro[2.4]heptane(129306-07-6)
• EPA Substance Registry System: 7-Amino-5-benzyl-5-azaspiro[2.4]heptane(129306-07-6)

Safety Data

• Hazardous Substances Data: 129306-07-6(Hazardous Substances Data)

Usage

General Description

7-Amino-5-benzyl-5-azaspiro[2.4]heptane, also known as ABH, is a chemical compound with a unique spirocyclic structure. It is a psychoactive substance and a potent, non-selective serotonin receptor agonist, which means it has the ability to stimulate serotonin receptors in the brain. ABH has been used in research to study the effects of serotonin agonists on behavior and physiology. Additionally, it has been investigated for its potential use in the treatment of certain mental health conditions, such as depression and anxiety. However, due to its psychoactive properties, ABH can have potential for abuse and may pose risks to human health. Therefore, its use is strictly regulated and controlled.

Upstream product

• 152719-33-0 5-benzyl-7-hydroxyimino-5-azaspiro[2.4]heptane 
• 331443-52-8 N-benzyl-1-(2-bromoacetyl)cyclopropanecarboxamide 
• 147011-39-0 1-acetyl-N-[benzyl]cyclopropane-1-carboxamide 
• 882-36-0 N-benzyl-3-oxobutanamide 
• 129306-06-5 4-oxo-5-benzyl-7-hydroxyimino-5-azaspiro[2,4]heptane 
• 129306-04-3 5-benzyl-5-azaspiro[2.4]heptane-4,7-dione 
• 129306-06-5 (7E)-5-benzyl-7-(hydroxyimino)-5-azaspiro[2.4]heptan-4-one 
• 1152111-03-9 (7Z)-5-phenylmethyl-5-azaspiro[2.4]heptane-4,7-dione 7-O-methyloxime 

Downstream Products

• 129306-13-4 5-phenylmethyl-N-(tert-butoxycarbonyl)-5-azaspiro[2.4]heptane-7-amine 
• 1152111-04-0 N,N-dimethyl-5-phenylmethyl-5-azaspiro[2.4]heptan-7-amine 
• 152513-88-7 (7S)-5-aza-7-tert-butoxycarbonylaminospiro[2.4]heptan 
• 144282-35-9 5-benzyl-7(S)-amino-5-azaspiro[2,4]heptane 

Relevant articles and documents

A 5-benzyl -7 (S)-tert-butoxycarbonylamino-5-azaspiro [2,4] heptane preparation method of

The invention discloses a preparation method for 5-benzyl-7(S)-t-butyloxycarborylamino-5-aza-spiro[2,4]heptane. The method comprises the following steps: reacting benzoylamide acetoacetate as a raw material with 1,2-dichloroethane to obtain 3-cyclopropyl benzoylamide acetoacetate, brominating 3-cyclopropyl benzoylamide acetoacetate by NBS (n-bromosuccinimide) to obtain 1-bromo-3-cyclopropyl benzoylamide acetoacetate, cyclizing under alkaline conditions to obtain 5-benzyl-5-aza-spiro[2,4]heptane-4,7-diketone, further reacting with hydroxylamine hydrochloride to form an oxime compound-4-oxo-5-benzyl-7-oximido-5-aza-spiro[2,4]heptane, reducing by NaBH4 and boron trifluoride diethyl etherate to obtain 5-benzyl-7-amino-5-aza-spiro[2,4]heptane, performing chiral resolution by a resolving agent-L-camphorsulfonic acid to obtain 5-benzyl-7(S)-amino-5-aza-spiro[2,4]heptane, and reacting with di-tert-butyl dicarbonate ester to obtain 5-benzyl-7(S)-t-butyloxycarborylamino-5-aza-spiro[2,4]heptane. According to the method, an intermediate body-carbonyl does not need protection, raw materials are easy to get, a process route is simple, and the method is suitable for industrial production.

SUBSTITUTED ALKYNYL PYRIDINE COMPOUNDS AND METHODS OF USE

The present invention provides novel substituted alkynyl pyridine compounds, pharmaceutical acceptable salts and formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating cellular activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.

Synthesis and In-Vitro Activity of Novel 1β-Methylcarbapenems Having Spiro[2,4]heptane Moieties

The synthesis of a new series of 1β-methylcarbapenems having spiro[2,4]heptane moieties is described. Their in-vitro antibacterial activities against both gram-positive and gram-negative bacteria were tested and the effect of substituents on the pyrrolidine ring was investigated. Most compounds were shown to be more active than the compared meropenem and imipenem against Escherichia coli. One particular compound, IIIb, having hydroxy a moiety showed the most potent antibacterial activity.