331443-52-8

Basic information

• Product Name: N-benzyl-1-(2-bromoacetyl)cyclopropanecarboxamide
• Synonyms: N-benzyl-1-(2-bromoacetyl)cyclopropanecarboxamide
• CAS NO: 331443-52-8
• Molecular Weight: 296.164
• Mol File: 331443-52-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-benzyl-1-(2-bromoacetyl)cyclopropanecarboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-1-(2-bromoacetyl)cyclopropanecarboxamide(331443-52-8)
• EPA Substance Registry System: N-benzyl-1-(2-bromoacetyl)cyclopropanecarboxamide(331443-52-8)

Safety Data

• Hazardous Substances Data: 331443-52-8(Hazardous Substances Data)

Upstream product

• 882-36-0 N-benzyl-3-oxobutanamide 
• 147011-39-0 1-acetyl-N-[benzyl]cyclopropane-1-carboxamide 

Downstream Products

• 129306-06-5 4-oxo-5-benzyl-7-hydroxyimino-5-azaspiro[2,4]heptane 
• 129306-07-6 5-benzyl-5-azaspiro[2.4]heptane-7-amine 
• 144282-35-9 5-benzyl-7(S)-amino-5-azaspiro[2,4]heptane 
• 1432056-70-6 5-benzyl-7(S)-tert-butoxycarbonylamino-5-azaspiro[2,4]heptane 
• 129306-04-3 5-benzyl-5-azaspiro[2.4]heptane-4,7-dione 

Relevant articles and documents

A 5-benzyl -7 (S)-tert-butoxycarbonylamino-5-azaspiro [2,4] heptane preparation method of

The invention discloses a preparation method for 5-benzyl-7(S)-t-butyloxycarborylamino-5-aza-spiro[2,4]heptane. The method comprises the following steps: reacting benzoylamide acetoacetate as a raw material with 1,2-dichloroethane to obtain 3-cyclopropyl benzoylamide acetoacetate, brominating 3-cyclopropyl benzoylamide acetoacetate by NBS (n-bromosuccinimide) to obtain 1-bromo-3-cyclopropyl benzoylamide acetoacetate, cyclizing under alkaline conditions to obtain 5-benzyl-5-aza-spiro[2,4]heptane-4,7-diketone, further reacting with hydroxylamine hydrochloride to form an oxime compound-4-oxo-5-benzyl-7-oximido-5-aza-spiro[2,4]heptane, reducing by NaBH4 and boron trifluoride diethyl etherate to obtain 5-benzyl-7-amino-5-aza-spiro[2,4]heptane, performing chiral resolution by a resolving agent-L-camphorsulfonic acid to obtain 5-benzyl-7(S)-amino-5-aza-spiro[2,4]heptane, and reacting with di-tert-butyl dicarbonate ester to obtain 5-benzyl-7(S)-t-butyloxycarborylamino-5-aza-spiro[2,4]heptane. According to the method, an intermediate body-carbonyl does not need protection, raw materials are easy to get, a process route is simple, and the method is suitable for industrial production.