13393-41-4

Basic information

• Product Name: 1H-Pyrazole, 4,5-dihydro-3-(4-methylphenyl)-1,5-diphenyl-
• CAS NO: 13393-41-4
• Molecular Formula: C22H20N2
• Molecular Weight: 312.414
• Mol File: 13393-41-4.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 1H-Pyrazole, 4,5-dihydro-3-(4-methylphenyl)-1,5-diphenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole, 4,5-dihydro-3-(4-methylphenyl)-1,5-diphenyl-(13393-41-4)
• EPA Substance Registry System: 1H-Pyrazole, 4,5-dihydro-3-(4-methylphenyl)-1,5-diphenyl-(13393-41-4)

Safety Data

• Hazardous Substances Data: 13393-41-4(Hazardous Substances Data)

Usage

Molecular Structure

1H-Pyrazole, 4,5-dihydro-3-(4-methylphenyl)-1,5-diphenylis a chemical compound that consists of a pyrazole ring structure, with a 4,5-dihydro-3-(4-methylphenyl) group and a 1,5-diphenyl group.

Usage

It is commonly used as a building block in organic synthesis and pharmaceutical research.

Potential Applications

1H-Pyrazole, 4,5-dihydro-3-(4-methylphenyl)-1,5-diphenylhas the potential for use in the development of new drugs, due to its diverse biological activities and pharmacological properties.

Medicinal Value

It has been studied for its potential in the treatment of various diseases and conditions, making it a valuable compound in the field of medicinal chemistry.

Upstream product

• 100-42-5 styrene 
• 20433-11-8 5-(4-methylphenyl)-2-phenyl-2H-tetrazole 
• 104-87-0 4-methyl-benzaldehyde 
• 100-63-0 phenylhydrazine 
• 100-52-7 benzaldehyde 
• 122-00-9 para-methylacetophenone 
• 59931-62-3 1-(4-methylphenyl)-3-phenylprop-2-yn-1-ol 
• 98-86-2 acetophenone 
• 4224-87-7 4-methyl-chalcone 
• 14802-30-3 (E)-1-(4-methylphenyl)-3-phenyl-2-propen-1-one 
• 4224-96-8 3-phenyl-1-p-tolylprop-2-en-1-one 

Downstream Products

• 95796-93-3 C₂₃H₂₀ClN₃O₃S 
• 105257-81-6 (4-Nitro-phenyl)-[4-(5-phenyl-3-p-tolyl-4,5-dihydro-pyrazol-1-yl)-phenyl]-diazene 
• 105257-79-2 Phenyl-[4-(5-phenyl-3-p-tolyl-4,5-dihydro-pyrazol-1-yl)-phenyl]-diazene 
• 105257-78-1 [4-(5-Phenyl-3-p-tolyl-4,5-dihydro-pyrazol-1-yl)-phenyl]-p-tolyl-diazene 
• 105257-80-5 (4-Chloro-phenyl)-[4-(5-phenyl-3-p-tolyl-4,5-dihydro-pyrazol-1-yl)-phenyl]-diazene 
• 92708-90-2 1-(4-Acetylphenyl)-3-(4-tolyl)-5-phenyl-2-pyrazoline 
• 63367-45-3 1-(4-Nitrophenyl)-3-(4-tolyl)-5-phenyl-2-pyrazoline 
• 1207173-25-8 1-(4'-thiocyanophenyl)-3-(4'-methylphenyl)-5-phenyl-pyrazoline 
• 95797-03-8 4-(5-Phenyl-3-p-tolyl-4,5-dihydro-pyrazol-1-yl)-benzamide 
• 16112-34-8 (1H)-1,5-diphenyl-3-(p-methylphenyl)pyrazole 

Relevant articles and documents

Regioselective 1,3-dipolar cycloaddition of nitriles with nitrile imines generated from tetrazoles

A synthesis of 3,5-disubstituted-1,2,4-triazoles from nitriles and 5-aryltetrazoles is reported. When 5-aryltetrazoles are triflylated in the presence of nitriles, the resulting 5-aryl-2-triflyltetrazoles thermally generate N-triflyl-nitrile imines through a sequence of ring-chain tautomerization and denitrogenation. The N-triflyl-nitrile imines immediately undergo 1,3-dipolar cycloaddition with nitriles in a regioselective manner, forming the corresponding 1,2,4-triazoles.

An eco-friendly synthesis of 2-pyrazoline derivatives catalysed by CeCl 3· 7 H 2O

Abstract: 1,3,5-triaryl-2-pyrazoline derivatives were synthesised by a condensation reaction between chalcones and phenyl hydrazine using cerium chloride heptahydrate as a catalyst. All these reactions were carried out in ethyl lactate (70%) as a green solvent. Easy and efficient work up, recyclability of solvent and catalyst are the key merits of this protocol. Graphical Abstract:: SYNOPSIS A facile protocol for the synthesis of 1,3,5-triaryl-2-pyrazolines is described. The solvent ethyl lactate, obtained from renewable sources, is biodegradable. The catalyst CeCl 3· 7 H 2O is a water-tolerant Lewis acid with low toxicity. Easy and clean work up, recyclable solvent and catalyst are merits of the protocol. The reaction works well for all systems giving good yields of the desired products.[Figure not available: see fulltext.].

A novel methodology for synthesis of dihydropyrazole derivatives as potential anticancer agents

A novel, simple, and efficient method for the synthesis of 4,5-dihydropyrazole derivatives has been developed. The reaction proceeded through the base-induced isomerization of easily accessible propargyl alcohols followed by cyclization of α,β-unsaturated hydrazones. Furthermore, selected compounds 3ab and 3ac exhibited good activities against Bel-7404 (human hepatoma cancer), HepG2 (human liver cancer), NCI-H460 (human lung cancer) and SKOV3 (human ovarian cancer) cell lines with IC50 in the range of 22-46 μmol L-1.