1351281-52-1

Basic information

• Product Name: methyl 5-(2-(benzyl(6-(4-phenylbutoxy)hexyl)amino)acetyl)-2-(benzyloxy)benzoate
• Synonyms: methyl 5-(2-(benzyl(6-(4-phenylbutoxy)hexyl)amino)acetyl)-2-(benzyloxy)benzoate
• CAS NO: 1351281-52-1
• Molecular Weight: 621.817
• Mol File: 1351281-52-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl 5-(2-(benzyl(6-(4-phenylbutoxy)hexyl)amino)acetyl)-2-(benzyloxy)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 5-(2-(benzyl(6-(4-phenylbutoxy)hexyl)amino)acetyl)-2-(benzyloxy)benzoate(1351281-52-1)
• EPA Substance Registry System: methyl 5-(2-(benzyl(6-(4-phenylbutoxy)hexyl)amino)acetyl)-2-(benzyloxy)benzoate(1351281-52-1)

Safety Data

• Hazardous Substances Data: 1351281-52-1(Hazardous Substances Data)

Upstream product

• 16475-90-4 estere metilico dell'acido 5-acetilsalicilico 
• 27475-09-8 5-acetyl-2-benzyloxybenzoic acid methyl ester 
• 163923-18-0 N-[6-(4-phenylbutoxy)hexyl] benzenemethanamine hydrochloride 
• 27475-14-5 2-benzyloxy-5-(2-bromoacetyl)benzoic acid methyl ester 
• 3360-41-6 4-phenyl-butan-1-ol 
• 629-03-8 1 ,6-dibromohexane 
• 94749-73-2 6-bromohexyl 4-phenylbutyl ether 
• 100-44-7 benzyl chloride 

Downstream Products

• 135271-49-7 salmeterol xinafoate 
• 89365-50-4 salmeterol 
• 943969-38-8 2-(benzyl-(6-(4-phenylbutoxy)hexyl)amino)-1-(4-(benzyloxy)-3-(hydroxymethyl)phenyl)ethanol 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF SALMETEROL AND ITS INTERMEDIATES

The present invention discloses a process for the preparation of methyl 2-(benzyloxy)- 5-(2-bromoacetyl)benzoate (V), comprising: (d) benzylating methyl-5-acetyl-2-hydroxybenzoate (VIII) with benzyl chloride in the presence of a base and a catalyst in a suitable polar solvent to obtain 5-acetyl-2- benzyloxy benzoate (VII); (e) brominating methyl 5-acetyl-2-(benzyloxy)benzoate (VII) with a suitable brominating agent in one or more suitable' solvents in the presence of an acid catalyst to obtain methyl 2-(benzyloxy)-5-(2-bromoacetyl)benzoate V; (c) optionally, purifying the methyl 2-(benzyloxy)-5-(2-bromoacetyl)benzoate (V) in a suitable solvent; and (f) isolating the methyl 2-(benzyloxy)-5-(2-bromoacetyl)benzoate (V).