13664-98-7

Basic information

• Product Name: 2,2-DIBROMO-1-P-TOLYLETHANONE
• Synonyms: 2,2-DIBROMO-1-P-TOLYLETHANONE;2,2-dibromo-1-(4-methylphenyl)ethanone
• CAS NO: 13664-98-7
• Molecular Formula: C₉H₈Br₂O
• Molecular Weight: 291.97
• Mol File: 13664-98-7.mol
• Article Data: 45

Chemical Properties

• Melting Point: 97-98 °C
• Boiling Point: 290.3±25.0 °C(Predicted)
• Appearance: /
• Density: 1.780±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2,2-DIBROMO-1-P-TOLYLETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-DIBROMO-1-P-TOLYLETHANONE(13664-98-7)
• EPA Substance Registry System: 2,2-DIBROMO-1-P-TOLYLETHANONE(13664-98-7)

Safety Data

• Hazardous Substances Data: 13664-98-7(Hazardous Substances Data)

Usage

General Description

2,2-DIBROMO-1-P-TOLYLETHANONE is a chemical compound that belongs to the group of benzyl ketones. It is a white to light yellow crystalline solid with a molecular formula of C9H8Br2O. 2,2-DIBROMO-1-P-TOLYLETHANONE is commonly used in organic synthesis and as a building block for the preparation of other compounds. It is also a useful intermediate in the production of pharmaceuticals, dyes, and other organic substances. 2,2-DIBROMO-1-P-TOLYLETHANONE is a potentially hazardous chemical and should be handled with caution, as it may cause skin and eye irritation and should be stored in a cool, dry place away from direct sunlight and heat sources.

Upstream product

• 67-66-3 chloroform 
• 7726-95-6 bromine 
• 122-00-9 para-methylacetophenone 
• 108-88-3 toluene 
• 619-41-0 4-(bromoacetyl)toluene 
• 766-97-2 4-n-methylphenylacetylene 
• 104-87-0 4-methyl-benzaldehyde 
• 93979-10-3 1-(p-methylphenyl)-2,2,2-tribromoethanol 
• 7559-36-6 4-methyl-β-nitrostyrene 
• 18103-98-5 3-dimethylamino-1-(4-methyl-phenyl)-2-propen-1-one 
• 536-50-5 CH₃C₆H₄CH(CH₃)OH 
• 622-97-9 1-ethenyl-4-methylbenzene 
• 94-08-6 4-methylbenzoic acid ethyl ester 
• 74-95-3 1,1-dibromomethane 

Downstream Products

• 201206-21-5 2,2-Dibromo-1-(4-methylphenyl)ethanone oxime 
• 99-94-5 p-Toluic acid 
• 30196-30-6 3,3'-di-p-tolyl-2H,2'H-2,2'-bibenzo[b][1,4]thiazine 
• 1068459-70-0 2-bromo-2-p-tolylpent-4-enal 
• 1194639-53-6 1,1-dimethoxy-2-p-tolylpent-4-en-2-ol 
• 1320341-22-7 N-(2,4-difluorophenyl)-4-(p-tolyl)thiazol-2-amine 
• 2103-91-5 2-amino-4-(p-methylphenyl)-1,3-thiazole 
• 61820-95-9 2-(toluene-4-sulfonyl)-1-p-tolylethanone 
• 17565-28-5 p-tolyl-glyoxal-bis-phenylhydrazone 
• 17286-62-3 2-(4-methylphenyl)quinoxaline 
• 120116-88-3 4-chloro-2-cyano-N,N-dimethyl-5-(4-methylphenyl)-1H-imidazole-1-sulfonamide 
• 120118-14-1 5-chloro-4-(4-methylphenyl)-1H-imidazole-2-carbonitrile 
• 619-41-0 4-(bromoacetyl)toluene 

Relevant articles and documents

A H2O2/HBr system-several directions but one choice: oxidation-bromination of secondary alcohols into mono- or dibromo ketones

In this work we found that a H2O2-HBr(aq) system allows synthesis of α-monobromo ketones and α,α′-dibromo ketones from aliphatic and secondary benzylic alcohols with yields up to 91%. It is possible to selectively direct the process toward the formation of mono- or dibromo ketones by varying the amount of hydrogen peroxide and hydrobromic acid. The convenience of application, simple equipment, multifaceted reactivity, and compliance with green chemistry principles make the application of the H2O2-HBr(aq) system very attractive in laboratories and industry. The proposed oxidation-bromination process is selective in spite of known properties of ketones to be oxidized by the Baeyer-Villiger reaction or peroxidated with the formation of compounds with the O-O moiety in the presence of hydrogen peroxide and Bronsted acids.

Electrochemical Oxidative Functionalization of Arylalkynes: Access to α,α-Dibromo Aryl Ketones

A general and effective protocol to synthesize α,α-dibromo aryl ketones has been developed via an electrochemical oxidative method. The reaction proceeds smoothly at room temperature in an undivided cell without the addition of external oxidants. In the reaction process, LiBr acts as both bromine source and supporting electrolyte. This electrooxidation strategy has good substrate applicability and functional group compatibility. Moreover, the reaction could be scaled up efficiently in a continuous flow cell. The target product could undergo further functionalization for the synthesis of some useful heterocyclic compounds. (Figure presented.).

Method for preparing alpha,alpha-dihalogenated acetophenone compound

The invention belongs to the technical field of organic synthesis and in particular relates to a method for preparing an alpha,alpha-dihalogenated acetophenone compound. The preparation method provided by the invention comprises the following steps: in an alcohol solvent, enabling nitroalkenes, electrophilic halogen reagents and sodium hydride to react at 55-65 DEG C under a heating condition for5-10 hours, cooling the components to the room temperature, adding a diluted acid solution, and performing continue stirring for 2-5 hours, so as to obtain a target compound, namely alpha,alpha-dihalogenated acetophenone. The method for preparing the alpha,alpha-dihalogenated acetophenone compound, which is provided by the invention, is simple and efficient, mild in condition, easy in raw materialobtaining, green and environment-friendly and simple and convenient to operate, and as a synthesis intermediate, the obtained alpha,alpha-dihalogenated acetophenone compound has the potential of being widely used in fields such as medicine chemical engineering.