1421749-23-6Relevant articles and documents
Salen, reduced salen and N-alkylated salen type compounds: Spectral characterization, theoretical investigation and biological studies
Jeslin Kanaga Inba,Annaraj,Thalamuthu,Neelakantan
, p. 300 - 309 (2013)
Salen [2,2′-{propane-1,3-diylbis[nitrilo(E)methylylidene]}bis(6- methoxyphenol)], reduced salen [(2,2′-[propane-1,3-diylbis(iminomethylene) )]bis(6-methoxyphenol)] and N-alkylated salen [diethyl-2,2′-(propane-1,3- diylbis((2-hydroxy-3-methoxybenzyl) azanediyl))diacetate] compounds have been synthesized and characterized by IR, 1H NMR, 13C NMR and UV-vis. spectroscopy. Molecular geometry of the title compounds in the ground state has been optimized by density functional method (B3LYP) with 6-31G basis set. Vibrational frequencies of the compounds were computed and compared with the experimental values. Tautomeric stability study of salen inferred that the enolimine form is more stable than its ketoenamine form in gas phase. The spectral behavior of salen in polar and nonpolar solvents was examined demonstrate the positive solvatochromism. The synthesized compounds have been studied with respect to their binding to calf thymus DNA showed that there were interactions between the compounds and DNA through a groove binding mode. Furthermore, the DNA cleavage activity of the compounds has been investigated by gel electrophoresis. The antioxidant properties of compounds were evaluated by DPPH method. The N-alkylated compound has a higher DPPH free radical scavenging activity. The antimicrobial activity was investigated on various gram positive and gram negative bacteria.
