1430073-67-8

Basic information

• Product Name: 1-(3'-deoxy-5'-O-DMT-2'-O,4'-C-methylenethymidin-3'-yl)-4-(5-deoxy-3-O-tert-butyldiphenylsilyl-β-thymidin-5-yl)mercaptoacetamide
• Synonyms: 1-(3'-deoxy-5'-O-DMT-2'-O,4'-C-methylenethymidin-3'-yl)-4-(5-deoxy-3-O-tert-butyldiphenylsilyl-β-thymidin-5-yl)mercaptoacetamide
• CAS NO: 1430073-67-8
• Molecular Weight: 1108.35
• Mol File: 1430073-67-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(3'-deoxy-5'-O-DMT-2'-O,4'-C-methylenethymidin-3'-yl)-4-(5-deoxy-3-O-tert-butyldiphenylsilyl-β-thymidin-5-yl)mercaptoacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3'-deoxy-5'-O-DMT-2'-O,4'-C-methylenethymidin-3'-yl)-4-(5-deoxy-3-O-tert-butyldiphenylsilyl-β-thymidin-5-yl)mercaptoacetamide(1430073-67-8)
• EPA Substance Registry System: 1-(3'-deoxy-5'-O-DMT-2'-O,4'-C-methylenethymidin-3'-yl)-4-(5-deoxy-3-O-tert-butyldiphenylsilyl-β-thymidin-5-yl)mercaptoacetamide(1430073-67-8)

Safety Data

• Hazardous Substances Data: 1430073-67-8(Hazardous Substances Data)

Upstream product

• 1430073-61-2 3'-azido-5'-O-benzoyl-3'-deoxy-2'-O-4'-C-methylenethymidine 
• 1430073-60-1 3'-azido-3'-deoxy-5'-O-methanesulfonyl-2'-O,4'-C-methylenethymidine 
• 1430073-59-8 2'-O-acetyl-3'-azido-3'-deoxy-5'-O-methanesulfonyl-4'-C-methanesulfonyloxymethyl-thymidine 
• 7253-19-2 5'-O-(p-toluenesulfonyl)thymidine 
• 50-89-5 thymidine 
• 65-71-4 thymin 
• 1430073-66-7 2-S-(5'-deoxy-3'-O-tert-butyldiphenylsilyl-β-thymidin-5'-yl)mercaptoacetic acid 
• 321882-29-5 3'-amino-3'-deoxy-5'-O-DMT-2'-O-4'-C-methylenethymidine 
• 321882-28-4 3'-azido-3'-deoxy-5'-O-DMT-2'-O-4'-C-methylenethymidine 
• 247025-17-8 3′-azido-3′-deoxy-2′-O,4′-C-methylene-5-methyluridine 

Downstream Products

• 1430073-70-3 1-(3'-deoxy-5'-O-DMT-2'-O,4'-C-methylenethymidin-3'-yl)-4-(5-deoxy-β-thymidin-5-yl)mercaptoacetamide 
• 1430073-73-6 1-(3'-deoxy-5'-O-DMT-2'-O,4'-C-methylenethymidin-3'-yl)-4-(3-O-β-cyanoethyl-N,N-diisopropylphosphoramidite-5-deoxy-β-thymidin-5-yl)mercaptoacetamide 

Relevant articles and documents

Design and synthesis of LNA-based mercaptoacetamido-linked nucleoside dimers

Three LNA-based mercaptoacetamido-linked nonionic nucleoside dimers T L-S-T, T-S-TL, and TL-S-TL have been synthesized by HOBT and HBTU catalyzed condensation of silyl-protected 2-S-(thymidin-5 ′-yl)mercaptoacetic acid or 2-S-(2 ′-O,4 ′-C-methylenethymidin-5 ′-yl)mercaptoacetic acid with 3 ′-amino-3 ′-deoxy-5 ′-O-DMT-2 ′-O,4 ′-C- methylenethymidine or with 3 ′-amino-3 ′-deoxy-5 ′-O-DMT-β-thymidine followed by desilylation of the protected dimers. The 3 ′-O-phosphoramidite derivative of one of the nucleoside dimers was successfully prepared by condensation with [P(-Cl)(-OCH2CH 2CN)-N(iPr)2}] in DCM in the presence of N,N-diisopropylethylamine (DIPEA), which is a building block for the preparation of mercaptoacetamido-linked oligonucleotides of therapeutic applications.