7253-19-2

Basic information

• Product Name: 5'-O-(4-METHYLPHENYLSULPHONYL)THYMIDINE
• Synonyms: 5’-o-tosylthymidine;5’-tosylthymidine;5'-O-TOLUOLSULFONYL-THYMIDINE;5'-O-(P-TOLUENESULFONYL)THYMIDINE;5'-O-(4-METHYLPHENYLSULPHONYL)THYMIDINE;5'-O-[(4-Methylphenylsulphonyl)thymidine 97%;5'-O-(p-Methylphenylsulfonyl)thymidine;Thymidine 5'-tosylate
• CAS NO: 7253-19-2
• Molecular Formula: C₁₇H₂₀N₂O₇S
• Molecular Weight: 396.41
• Product Categories: Bases & Related Reagents;Nucleotides;Protein Kinase Inhibitors and Activators;Sulfur & Selenium Compounds
• Mol File: 7253-19-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.425 g/cm³
• Refractive Index: 1.597
• Storage Temp.: -20°C Freezer
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 5'-O-(4-METHYLPHENYLSULPHONYL)THYMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-O-(4-METHYLPHENYLSULPHONYL)THYMIDINE(7253-19-2)
• EPA Substance Registry System: 5'-O-(4-METHYLPHENYLSULPHONYL)THYMIDINE(7253-19-2)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 7253-19-2(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 7253-19-2 differently. You can refer to the following data:
1. A nucleoside analogue as inhibitors of thymidylate kinases
2. A nucleoside analogue as inhibitors of thymidylate kinases.

InChI:InChI=1/C17H20N2O7S/c1-10-3-5-12(6-4-10)27(23,24)25-9-14-13(20)7-15(26-14)19-8-11(2)16(21)18-17(19)22/h3-6,8,13-15,20H,7,9H2,1-2H3,(H,18,21,22)

Upstream product

• 50-89-5 thymidine 
• 137121-87-0 α/β-D-thymidine 
• 98-59-9 p-toluenesulfonyl chloride 
• 40733-27-5 3'-O-(t-butyldimethylsilyl)thymidine 
• 129801-99-6 3'-O-(tert-butyldimethylsilyl)-5'-O-(p-toluenesulfonyl)thymidine 

Downstream Products

• 177738-46-4 5'-S-(4,4'-dimethoxytrityl)-5'-thiothymidine 
• 55812-00-5 5'-trifluoroacetamide-5'-deoxy-thymidine 
• 75145-86-7 3'-O-acetyl-5'-O-tosylthymidine 
• 1430073-73-6 1-(3'-deoxy-5'-O-DMT-2'-O,4'-C-methylenethymidin-3'-yl)-4-(3-O-β-cyanoethyl-N,N-diisopropylphosphoramidite-5-deoxy-β-thymidin-5-yl)mercaptoacetamide 
• 1430073-70-3 1-(3'-deoxy-5'-O-DMT-2'-O,4'-C-methylenethymidin-3'-yl)-4-(5-deoxy-β-thymidin-5-yl)mercaptoacetamide 
• 1430073-67-8 1-(3'-deoxy-5'-O-DMT-2'-O,4'-C-methylenethymidin-3'-yl)-4-(5-deoxy-3-O-tert-butyldiphenylsilyl-β-thymidin-5-yl)mercaptoacetamide 
• 1430073-66-7 2-S-(5'-deoxy-3'-O-tert-butyldiphenylsilyl-β-thymidin-5'-yl)mercaptoacetic acid 
• 15425-09-9 3,5'-cyclo-2'-deoxyguanosine 
• 1038442-96-4 3'-O-propargyl-5'-O-tosylthymidine 
• 115179-56-1 5'-(4-chlorobenzylamino)-5'-deoxythymidine 
• 129789-26-0 5'-Azido-thymidinylacetamido-<3'(O)-5'(C)>-N⁶-(4-methoxytrityl)-5',2'-dideoxyadenosine 
• 129789-29-3 5'-Amino-thymidinylacetamido-<3'(O)-5'(C)>-N⁶-(4-methoxytrityl)-5',2'-dideoxyadenosine 
• 129789-18-0 5'-O-(4-Monomethoxytriphenylmethyl)-thymidinylacetamido-3(C)-5'(C)>-5'-deoxythymidine 
• 129789-28-2 5'-Azido-thymidinylacetamido-<3'(O)-5'(C)>-5',2'-dideoxyadenosine 

Relevant articles and documents

Solid-phase synthesis and evaluation of TAR RNA targeted β-carboline-nucleoside conjugates

Four types of β-carboline-nucleoside conjugates were synthesized. The binding affinities of these β-carboline-nucleoside conjugates 4-11, 13 and 15 to TAR RNA were evaluated by affinity capillary electrophoresis. The data of binding affinities to TAR RNA show that conjugates 9 and 13 are stronger binders than the parent compound MC3. Computer modeling indicates that the β-carboline-nucleoside conjugate 13 can fit to the UCU three-nucleotide bulge region of TAR RNA. The Royal Society of Chemistry 2008.

Novel diastereomeric thymidine cyclic 3',5'-threo-phosphoramidates

Novel diastereomeric thymidine cyclic 3',5'-threo-phosphoramidates were prepared by the treatment of 5'-azido derivative of threo-thymidine with triphenyl phosphite as well as by the treatment of the corresponding amino derivative with phenyl phosphodichloridate. Phosphoramidation of the regioisomeric 3'- and 5'-azido derivatives of erythro-thymidine by means of triphenyl phosphite afforded the open-chain 3'- and 5'-phosphoramidates. The reaction which afforded the cyclic products was assumed to proceed via the cyclic tetraoxazaphosphorane intermediates.

Novel P1,P2-substituted phosphonate analogues of 2'-deoxyadenosine and 2'-deoxythymidine 5'-triphosphates

P1,P2-Substituted methylene, fluoromethylene, and difluoromethylene analogues of the deoxynucleotides 2'-deoxyadenosine 5'-triphosphate and thymidine 5'-triphosphate have been prepared by reaction between the bisphosphonic acid and t