144397-70-6

Basic information

• Product Name: 4-(4-PYRIDINYL)BENZONITRILE
• Synonyms: AKOS BAR-0612;4-(4-PYRIDINYL)BENZONITRILE;4-PYRIDIN-4-YL-BENZONITRILE;4-(4-Pyridyl)benzonitrile（WS203643）
• CAS NO: 144397-70-6
• Molecular Formula: C₁₂H₈N₂
• Molecular Weight: 180.21
• Mol File: 144397-70-6.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(4-PYRIDINYL)BENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-PYRIDINYL)BENZONITRILE(144397-70-6)
• EPA Substance Registry System: 4-(4-PYRIDINYL)BENZONITRILE(144397-70-6)

Safety Data

• Hazardous Substances Data: 144397-70-6(Hazardous Substances Data)

Upstream product

• 623-03-0 4-Cyanochlorobenzene 
• 1692-15-5 4-pyridylboronic acid 
• 110-86-1 pyridine 
• 19524-06-2 4-bromopyridine hydrochloride 
• 126747-14-6 4-cyanophenylboronic acid 
• 623-00-7 4-bromobenzenecarbonitrile 
• 55-22-1 pyridine-4-carboxylic acid 
• 619-65-8 4-cyanobenzoic Acid 
• 25108-37-6 potassium pyridine-4-carboxylate 
• 3058-39-7 4-iodobenzonitrile 
• 113964-72-0 triphenyl(pyridin-4-yl)phosphonium trifluoromethanesulfonate 
• 5938-16-9 4-(4-methoxylphenyl)pyridine 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 

Downstream Products

• 460365-22-4 4-(1,2,3,6-tetrahydropyridin-4-yl)benzonitrile 
• 486437-10-9 4-(pyridin-4-yl)-benzylamine 
• 1334717-74-6 7-chloro-2-ethyl-N-[4-(pyridin-4-yl)benzyl]imidazo[1,2-a]pyridine-3-carboxamide 
• 1146444-72-5 4-(3-chloro-phenylamino)-3-[4-(pyrid-4-yl)-benzylamino]-1H-pyrazolo[3,4-d]pyrimidine 

Relevant articles and documents

Tunable Second-Level Room-Temperature Phosphorescence of Solid Supramolecules between Acrylamide–Phenylpyridium Copolymers and Cucurbit[7]uril

A series of solid supramolecules based on acrylamide–phenylpyridium copolymers with various substituent groups (P?R: R=?CN, ?CO2Et, ?Me, ?CF3) and cucurbit[7]uril (CB[7]) are constructed to exhibit tunable second-level (from 0.9 s to

Arene Cyanation via Cation-Radical Accelerated-Nucleophilic Aromatic Substitution

Herein we describe a cation radical-accelerated-nucleophilic aromatic substitution (CRA-SNAr) of alkoxy arenes utilizing a highly oxidizing acridinium photoredox catalyst and acetone cyanohydrin, an inexpensive and commercially available cyanide source. This cyanation is selective for carbon-oxygen (C-O) bond functionalization and is applicable to a range of methoxyarenes and dimethoxyarenes. Furthermore, computational studies provide a model for predicting regioselectivity and chemoselectivity in competitive C-H and C-O cyanation of methoxyarene cation radicals.

Identification of Adenine and Benzimidazole Nucleosides as Potent Human Concentrative Nucleoside Transporter 2 Inhibitors: Potential Treatment for Hyperuricemia and Gout

To test the hypothesis that inhibitors of human concentrative nucleoside transporter 2 (hCNT2) suppress increases in serum urate levels derived from dietary purines, we previously identified adenosine derivative 1 as a potent hCNT2 inhibitor (IC50 = 0.64 μM), but further study was hampered due to its poor solubility. Here we describe the results of subsequent research to identify more soluble and more potent hCNT2 inhibitors, leading to the discovery of the benzimidazole nucleoside 22, which is the most potent hCNT2 inhibitor (IC50 = 0.062 μM) reported to date. Compound 22 significantly suppressed the increase in plasma uric acid levels after oral administration of purine nucleosides in rats. Because compound 22 was poorly absorbed orally in rats (F = 0.51%), its pharmacologic action was mostly limited to the gastrointestinal tract. These findings suggest that inhibition of hCNT2 in the gastrointestinal tract can be a promising approach for the treatment of hyperuricemia.