150726-83-3

Basic information

• Product Name: 4,6-dichloro-5-(o-methoxyphenoxy)-2-methyl-pyrimidine
• Synonyms: 4,6-dichloro-5-(o-methoxyphenoxy)-2-methyl-pyrimidine
• CAS NO: 150726-83-3
• Molecular Weight: 285.13
• Mol File: 150726-83-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4,6-dichloro-5-(o-methoxyphenoxy)-2-methyl-pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-dichloro-5-(o-methoxyphenoxy)-2-methyl-pyrimidine(150726-83-3)
• EPA Substance Registry System: 4,6-dichloro-5-(o-methoxyphenoxy)-2-methyl-pyrimidine(150726-83-3)

Safety Data

• Hazardous Substances Data: 150726-83-3(Hazardous Substances Data)

Upstream product

• 20730-58-9 2-(2-Methoxyphenoxy)propanedioic acid diethyl ester 
• 329924-93-8 5-(o-methoxyphenoxy)-4,6-dihydroxy-2-methyl-pyrimidine 

Downstream Products

• 150726-07-1 p-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(o-methoxy-phenoxy)-2-methyl-4-pyrimidinyl]benzenesulfonamide 
• 167402-17-7 pyridin-2-ylcarbamic acid 2-[6-(4-tert-butyl-phenylsulfonylamino)-5-(2-methoxy-phenoxy)-2-methyl-pyrimidin-4-yloxy]-ethyl ester 
• 346671-50-9 5-methyl-N-[6-(4-hydroxy-2-butynyloxy)-5-(o-methoxyphenoxy)-2-methyl-4-pyrimidinyl]-2-pyridine sulfonamide 
• 329924-98-3 5-methyl-N-[6-chloro-5-(o-methoxyphenoxy)-2-methyl-4-pyrimidinyl]-2-pyridine sulfonamide 
• 150726-86-6 4-tert-butyl-N-[6-chloro-5-(o-methoxyphenoxy)-2-methyl-4-pyrimidinyl]-benzene sulfonamide 
• 167404-31-1 4-tert-butyl-N-[6-(2-amino-ethoxy)-5-(2-methoxy-phenoxy)-2-methyl-pyrimidin-4-yl]-benzene-sulfonamide 
• 346671-48-5 5-isopropyl-N-[6-chloro-5-(o-methoxyphenoxy)-2-methyl-4-pyrimidinyl]-2-pyridine sulfonamide 

Relevant articles and documents

The use of sulfonylamido pyrimidines incorporating an unsaturated side chain as endothelin receptor antagonists

A series of compounds structurally related to bosentan 1 featuring an unsaturated side chain at position 6 of the core pyrimidine have been studied for their potential to block the ETA and ETB receptor. Incorporation of a 2-butyne-1,4-diol linker bearing a pyridyl carbamoyl moiety led to in vitro highly potent endothelin receptor antagonists (e.g., 70 and 75). The propargyl derivative 26 significantly reduced blood pressure in in vivo model studies with hypertensive salt-sensitive Dahl rats.

6 alkoxy-4-pyrimidinyl bis-sulfonamides

The present invention relates to novel bis-sulfonamides represented, for example, by formula I below and a pure diastereomer, a mixture of diastereomers, a diastereomeric racemate, a mixture of diastereomeric racemates and meso-forms and a pharmaceutically acceptable salt thereof, wherein R1represents aryl; aryl-lower alkyl; aryl-lower alkenyl; heteroaryl; or heteroaryl-lower alkyl; and R2represents lower alkyl; trifluoromethyl; lower alkoxy-lower alkyl; lower alkenyl; lower alkynyl; aryl; aryl-lower alkyl; aryl-lower alkenyl; heterocyclyl; heterocyclyl-lower alkyl; heteroaryl; heteroaryl-lower alkyl; cycloalkyl; or cycloalkyl-lower alkyl. The present invention also relates to a process for manufacturing those compounds, pharmaceutical compositions containing one or more of those compounds as endothelin antagonists, and a method of treating a subject having a disorder involving endothelin with the compounds of the invention.

Discovery of Ro 48-5695: A potent mixed endothelin receptor antagonist optimized from Bosentan

Implementation of a pyridylcarbamoyl group and an isopropylpyridylsulfonamide substituent as key components in the scaffold of Bosentan resulted in the identification of the potent orally active endothelin receptor antagonist Ro 48-5695. It shows affinities for ET(A) and ET(B) receptors in the low nanomolar range and high functional antagonistic potency in vitro.