167402-17-7

Basic information

• Product Name: pyridin-2-ylcarbamic acid 2-[6-(4-tert-butyl-phenylsulfonylamino)-5-(2-methoxy-phenoxy)-2-methyl-pyrimidin-4-yloxy]-ethyl ester
• CAS NO: 167402-17-7
• Molecular Weight: 607.687
• Mol File: 167402-17-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: pyridin-2-ylcarbamic acid 2-[6-(4-tert-butyl-phenylsulfonylamino)-5-(2-methoxy-phenoxy)-2-methyl-pyrimidin-4-yloxy]-ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: pyridin-2-ylcarbamic acid 2-[6-(4-tert-butyl-phenylsulfonylamino)-5-(2-methoxy-phenoxy)-2-methyl-pyrimidin-4-yloxy]-ethyl ester(167402-17-7)
• EPA Substance Registry System: pyridin-2-ylcarbamic acid 2-[6-(4-tert-butyl-phenylsulfonylamino)-5-(2-methoxy-phenoxy)-2-methyl-pyrimidin-4-yloxy]-ethyl ester(167402-17-7)

Safety Data

• Hazardous Substances Data: 167402-17-7(Hazardous Substances Data)

Upstream product

• 150726-07-1 p-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(o-methoxy-phenoxy)-2-methyl-4-pyrimidinyl]benzenesulfonamide 
• 150726-83-3 4,6-dichloro-5-(o-methoxyphenoxy)-2-methyl-pyrimidine 
• 4013-71-2 pyridine-2-carbonyl azide 

Relevant articles and documents

Discovery of Ro 48-5695: A potent mixed endothelin receptor antagonist optimized from Bosentan

Implementation of a pyridylcarbamoyl group and an isopropylpyridylsulfonamide substituent as key components in the scaffold of Bosentan resulted in the identification of the potent orally active endothelin receptor antagonist Ro 48-5695. It shows affinities for ET(A) and ET(B) receptors in the low nanomolar range and high functional antagonistic potency in vitro.