16112-32-6

Basic information

• Product Name: 2-(4-methylphenyl)-5-phenyl-1,3,4-thiadiazole
• Synonyms: 2-(4-methylphenyl)-5-phenyl-1,3,4-thiadiazole
• CAS NO: 16112-32-6
• Molecular Weight: 252.34
• Mol File: 16112-32-6.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2-(4-methylphenyl)-5-phenyl-1,3,4-thiadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methylphenyl)-5-phenyl-1,3,4-thiadiazole(16112-32-6)
• EPA Substance Registry System: 2-(4-methylphenyl)-5-phenyl-1,3,4-thiadiazole(16112-32-6)

Safety Data

• Hazardous Substances Data: 16112-32-6(Hazardous Substances Data)

Upstream product

• 874-60-2 4-methyl-benzoyl chloride 
• 613-94-5 benzoic acid hydrazide 
• 52693-87-5 4-methylbenzaldehyde hydrazone 
• 104-87-0 4-methyl-benzaldehyde 
• 2168-78-7 methyl dithiobenzoate 
• 21464-13-1 2-(4-(bromomethyl)phenyl)-5-phenyl-1,3,4-oxadiazole 
• 1874-47-1 2-(4-methylphenyl)-5-phenyl-1,3,4-oxadiazole 
• 591-50-4 iodobenzene 
• 119072-55-8 tert-butylisonitrile 
• 71025-26-8 4-methylthiobenzoylhydrazine 
• 20605-40-7 thiobenzoylhydrazine 
• 4291-14-9 phenyl-1,3,4-thiadiazole 
• 123726-16-9 bis(4-methylphenyl)iodonium trifluoromethanesulfonate 
• 106-38-7 para-bromotoluene 

Downstream Products

• 16157-45-2 2-phenyl-5-(4-trans-styryl-phenyl)-[1,3,4]thiadiazole 
• 16157-46-3 2-[4-(trans-2-biphenyl-4-yl-vinyl)-phenyl]-5-phenyl-[1,3,4]thiadiazole 
• 1203959-20-9 2-(4-(bromomethyl)phenyl)-5-phenyl-1,3,4-thiadiazole 
• 1557164-62-1 4-(5-phenyl-1,3,4-thiadiazol-2-yl)benzaldehyde 

Relevant articles and documents

Structural studies of 2,5-disubstituted 1,3,4-thiadiazole derivatives from dithioesters under the mild condition: Studies on antioxidant, antimicrobial activities, and molecular docking

A series of 2,5-disubstituted 1,3,4-thiadiazole was synthesized and evaluated for their antioxidant and molecular docking studies. These molecules were efficiently synthesized under mild and inexpensive starting material. Construction of these molecules developed using substituted aldehydes and substituted dithioesters in presence of NCS (N-Chorosuccinimide). The compounds 4a, 4b, 4c, 4f, and 4k showed good antibacterial and antioxidant activity among which, 4k possess excellent antibacterial and antioxidant activity. The results of antioxidant activity studies revealed that compound 4k manifested profound antioxidant potential. The molecular docking study was performed with respective newly synthesized compounds to ascertain the binding mode of 4k with respect to the critical proteins involved in biosynthesis and metabolic pathways.

Palladium-catalyzed one-pot synthesis of diazoles via tert-butyl isocyanide insertion

An efficient one-pot palladium-catalyzed reaction for the synthesis of diazoles from readily available hydrazides and aryl halide via isocyanide insertion/cyclization sequence has been developed. This methodology efficiently constructs diazoles in good to excellent yields with the advantages of wide functional group tolerance and operational simplicity.

C-H arylation of azaheterocycles: A direct ligand-free and Cu-catalyzed approach using diaryliodonium salts

An efficient and high yielding Cu-catalyzed direct C-H arylation of azaheterocycles including oxadiazoles, thiadiazoles, benzoxazoles and benzothiazoles has been achieved by employing easily accessible diaryliodonium salts. the Partner Organisations 2014.