1617-90-9Relevant articles and documents
Ozonation in Alkaloid Chemistry: a Mild and Selective Conversion of Vincadifformine into Vincamine
Danieli, Bruno,Lesma, Giordano,Palmisano, Giovanni,Gabetta, Bruno
, p. 908 - 909 (1981)
Vincamine has been obtained in a 'one-pot' method by ozonation of vincadifformine.
SYNTHESIS OF VINCA ALKALOIDS AND RELATED COMPOUNDS. PART 18. STEREOCHEMICAL INVESTIGATIONS ON SOME INTERMEDIATES LEADING TO (+)-VINCAMINE
Szabo, Lajos,Kolonits, Pal,Kalaus, Gyoergy,Szantay, Csaba,Kalman, Alajos,et al.
, p. 1629 - 1636 (1984)
The C-2' absolute configrations of hydroxy esters (1) and (2) have been determined by X-ray analysis.The absolute configurations at C-15 of several compounds with the E-homoeburnane skeleton and the relative configurations at C-14 and -15 of compound (8) have been elucidated.The dominant conformation of compounds (3)-(7) have been established on the basis of 13C n.m.r. and c.d.spectroscopic results.A new method has been elaborated for the preparation of oxime (10), a compound of importance in the synthesis of Vinca alkaloids.
Alpneumines A-H, new anti-melanogenic indole alkaloids from Alstonia pneumatophora
Koyama, Koichiro,Hirasawa, Yusuke,Hosoya, Takahiro,Hoe, Teh Chin,Chan, Kit-Lam,Morita, Hiroshi
, p. 4415 - 4421 (2010)
Eight new indole alkaloids, alpneumines A-H (1-8) were isolated from the Malaysian Alstonia pneumatophora (Apocynaceae) and their structures were determined by MS and 2D NMR spectroscopic methods. Alpneumines E and G (5 and 7), vincamine, and apovincamine showed anti-melanogenesis in B16 mouse melanoma cells.
Kuehne
, p. 2946 (1964)
Synthesis of vinca alkaloids and related compounds LX. A simple transformation of apovincamine into vincamine
Moldvai, Istvan,Szantay Jr., Csaba,Rissanen, Kari,Szantay, Csaba
, p. 4999 - 5008 (1992)
The 15α-chloro-vincamine derivative 2 was prepared and proved to be key intermediate of a two-step transformation of apovincamine into vincamine. The structure of 2 was established via detailed NMR and X-ray investigations.
Intermediate, preparation method and application of intermediate in synthesis of vincamine
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, (2021/09/01)
The invention relates to the technical field of chemical drug synthesis, and discloses an intermediate, a preparation method and application of the intermediate in synthesis of vincamine. A modular synthesis strategy is adopted, and a compound 1 with a D ring structure and a C20 quaternary carbon center and a tryptophol derivative 7 (namely the compound 7) with an indole ring are adopted as synthesis blocks for synthesis. The synthesis method is efficient; each step of the synthesis route is simple in reaction; the used reagent and solvent are cheap and easy to obtain; the operation is simple and convenient; the yield is high; and large-scale production is easy.
Preparation method of high-purity vinpocetine (by machine translation)
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Paragraph 0041; 0043-0044; 0051-0056, (2020/04/17)
The preparation method, of the high-purity vinpocetine :S1. comprises, following steps: preparing vinpocstine, by dissolving; in toluene as a solvent; in toluene as a solvent ;S2. and carrying out an ester exchange reaction, to obtain the intermediate vinpocstine nitrogen oxide, in a toluene as a solvent, and carrying out an ester exchange reaction to obtain a product impurity at least ;S3. purity S2 and, % by mass of a solvent . The preparation method of the vinpocstine nitrogen oxide reaction solution in step, is adopted as a catalyst for carrying out an ester exchange reaction to obtain a long spring cavoniflorac sodium/vinpocstine . The process production operation is, simple, avoids the high, 99.9% toxicity reagent, to obtain a, long spring cavonift, nitrogen oxide reaction, solution to, obtain a product, impurity at a time of acid. (by machine translation)
