16526-56-0 Usage
Description
2-Methyladenosine is a type of methyladenosine in which the methyl group is located at position 2 on the adenine ring. It is a modified nucleoside that plays a crucial role in various biological processes, including gene expression regulation and cellular function.
Uses
Used in Pharmaceutical Industry:
2-Methyladenosine is used as a therapeutic agent for the treatment of various diseases. Its application in the pharmaceutical industry is due to its ability to modulate gene expression and influence cellular processes, making it a potential candidate for drug development.
Used in Biotechnology Industry:
In the biotechnology industry, 2-methyladenosine is used as a research tool for studying the role of epigenetic modifications in gene regulation. Its involvement in cellular processes makes it an essential molecule for understanding the underlying mechanisms of various diseases and developing targeted therapies.
Used in Diagnostics:
2-Methyladenosine can be used as a biomarker in the diagnostics industry to identify and monitor certain diseases. Its presence in cells and its association with specific biological processes make it a valuable indicator for disease progression and response to treatment.
Used in Drug Delivery Systems:
Similar to gallotannin, 2-methyladenosine can also be incorporated into drug delivery systems to enhance its therapeutic potential. By using various carriers such as organic and metallic nanoparticles, the delivery, bioavailability, and therapeutic outcomes of 2-methyladenosine can be improved, making it a more effective treatment option for various diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 16526-56-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,5,2 and 6 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 16526-56:
(7*1)+(6*6)+(5*5)+(4*2)+(3*6)+(2*5)+(1*6)=110
110 % 10 = 0
So 16526-56-0 is a valid CAS Registry Number.
InChI:InChI=1/C11H15N5O4/c1-4-14-9(12)6-10(15-4)16(3-13-6)11-8(19)7(18)5(2-17)20-11/h3,5,7-8,11,17-19H,2H2,1H3,(H2,12,14,15)/t5-,7-,8-,11-/m1/s1
16526-56-0Relevant articles and documents
Convenient Method for the Synthesis of C-Alkylated Purine Nucleosides: Palladium-Catalyzed Cross-Coupling Reaction of Halogenopurine Nucleosides with Trialkylaluminums
Hirota, Kosaku,Kitade, Yukio,Kanbe, Yoshitake,Maki, Yoshifumi
, p. 5268 - 5270 (1992)
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Isolation and characterization of 2-methyladenosine from Escherichia coli tRNA Glu 2 , tRNA Asp 1 , tRNA His 1 and tRNA Arg .
Saneyoshi,Oashi,Harada,Nishimura
, p. 1 - 10 (1972)
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Discovery of new S-adenosylmethionine decarboxylase inhibitors for the treatment of Human African Trypanosomiasis (HAT)
Hirth, Bradford,Barker Jr., Robert H.,Celatka, Cassandra A.,Klinger, Jeffrey D.,Liu, Hanlan,Nare, Bakela,Nijjar, Amarjit,Phillips, Margaret A.,Sybertz, Edmund,Willert, Erin K.,Xiang, Yibin
scheme or table, p. 2916 - 2919 (2010/02/28)
Modification of the structure of trypanosomal AdoMetDC inhibitor 1 (MDL73811) resulted in the identification of a new inhibitor 7a, which features a methyl substituent at the 8-position. Compound 7a exhibits improved potencies against both the trypanosomal AdoMetDC enzyme and parasites, and better blood brain barrier penetration than 1.
Antiviral Activity of C-Alkylated Purine Nucleosides Obtained by Cross-Coupling with Tetraalkyltin Reagents
Aerschot, Arthur A. Van,Mamos, Petros,Weyns, Nancy J.,Ikeda, Satoru,Clercq, Erik De,Herdewijn, Piet A.
, p. 2938 - 2942 (2007/10/02)
2-, 6-, And 8-alkylated (methyl, ethyl, and vinyl) adenosine analogues were synthesized by a palladium-catalyzed cross-coupling of a tetraalkyltin with the halogenated purine nucleosides.The synthesis of the 8-substituted analogues was accomplished using a transient protection procedure.The 6-alkylated-9-β-D-ribofuranosylpurines as well as 2-ethyladenosine were cytotoxic at relatively low concentrations (0.8-10 μg/mL). 8-Methyladenosine was a potent and selective inhibitor of vaccinia virus, whereas 8-ethyl- and 8-vinyladenosine were specifically inhibitory to respiratory syncytial virus. 8-Vinyladenosine displayed particular activity against herpes simplex virus (type 1).