166814-53-5

Basic information

• Product Name: N,N'-bis(BOC-β-alanyl)-1,4-diaminobenzene
• Synonyms: N,N'-bis(BOC-β-alanyl)-1,4-diaminobenzene
• CAS NO: 166814-53-5
• Molecular Weight: 450.535
• Mol File: 166814-53-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N,N'-bis(BOC-β-alanyl)-1,4-diaminobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: N,N'-bis(BOC-β-alanyl)-1,4-diaminobenzene(166814-53-5)
• EPA Substance Registry System: N,N'-bis(BOC-β-alanyl)-1,4-diaminobenzene(166814-53-5)

Safety Data

• Hazardous Substances Data: 166814-53-5(Hazardous Substances Data)

Upstream product

• 3303-84-2 3-(tert-butyloxycarbonylamino)propionic acid 
• 624-18-0 benzene-1,4-diamine hydrochloride 
• 106-50-3 1,4-phenylenediamine 

Downstream Products

• 192699-04-0 N,N'-bis[(6-chloropicolinyl)-L-Ser(t-Bu)-β-Ala]-1,4-phenylenediamine 
• 192699-05-1 N,N'-bis[(6-chloropicolinyl)-L-Ser-β-Ala]-1,4-phenylenediamine 
• 192699-03-9 (S)-2-Amino-N-(2-{4-[3-((S)-2-amino-3-tert-butoxy-propionylamino)-propionylamino]-phenylcarbamoyl}-ethyl)-3-tert-butoxy-propionamide 
• 215528-82-8 (2-benzyloxy-1-{2-[4-(3-{3-benzyloxy-2-[(9H-fluoren-9-ylmethoxycarbonyl)-methyl-amino]-propionylamino}-propionylamino)-phenylcarbamoyl]-ethylcarbamoyl}-ethyl)-methyl-carbamic acid 9H-fluoren-9-ylmethyl ester 
• 273928-40-8 C₄₂H₅₄N₈O₈ 
• 166814-76-2 C₄₂H₅₀N₈O₈ 
• 273928-41-9 C₄₀H₅₀N₈O₈ 
• 166814-77-3 C₄₂H₄₆N₈O₈ 
• 166814-83-1 C₄₆H₅₀N₈O₈ 
• 166814-55-7 C₄₄H₄₆N₈O₈ 
• 166814-54-6 [2-benzyloxy-1-(2-{4-[3-(3-benzyloxy-2-tert-butoxycarbonylamino-propionylamino)-propionylamino]-phenylcarbamoyl}-ethylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester 
• 166814-78-4 (S)-2-Amino-N-(2-{4-[3-((S)-2-amino-3-benzyloxy-propionylamino)-propionylamino]-phenylcarbamoyl}-ethyl)-3-benzyloxy-propionamide 
• 166814-66-0 (S)-4-{2-[4-(3-{(S)-4-Benzyloxycarbonyl-2-[((S)-5-oxo-pyrrolidine-2-carbonyl)-amino]-butyrylamino}-propionylamino)-phenylcarbamoyl]-ethylcarbamoyl}-4-[((S)-5-oxo-pyrrolidine-2-carbonyl)-amino]-butyric acid benzyl ester 
• 166814-65-9 (S)-4-(2-{4-[3-((S)-4-Benzyloxycarbonyl-2-tert-butoxycarbonylamino-butyrylamino)-propionylamino]-phenylcarbamoyl}-ethylcarbamoyl)-4-tert-butoxycarbonylamino-butyric acid benzyl ester 

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Synthesis of a tritium labelled analog of the novel hematoregulatory agent SB 209978

[3H]-SB 209978 (10) was synthesized in 6 steps from phenylene diamine dihydrochloride. A key aspect was the regioselective synthesis of 6-chloropicolinic acid (7). This was condensed with diamine 6 and the resulting product was deprotected to give 9. Palladium catalyzed 3H-hydrogenolysis of the chloropyridine rings gave the final produce 10.