174543-79-4 Usage
General Description
1-piperidinecarboxylic acid, 3-(aminocarbonyl)-3-methyl-, phenylmethyl ester, also known as J147, is a small molecule drug with potential neuroprotective and cognitive-enhancing effects. It has been studied for its potential to mitigate neurodegenerative diseases such as Alzheimer's and Parkinson's. J147 has been shown to possess antioxidant, anti-inflammatory, and anti-amyloidogenic properties, which may help in protecting neurons from damage and improving cognitive function. Additionally, J147 has shown promise in increasing the production of brain-derived neurotrophic factor (BDNF), a protein crucial for the growth and survival of neurons. These findings suggest that J147 could be a promising candidate for the development of novel therapies for neurodegenerative diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 174543-79-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,4,5,4 and 3 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 174543-79:
(8*1)+(7*7)+(6*4)+(5*5)+(4*4)+(3*3)+(2*7)+(1*9)=154
154 % 10 = 4
So 174543-79-4 is a valid CAS Registry Number.
174543-79-4Relevant articles and documents
On the Ritter reaction of cyclic hydroxyamines: Synthesis of conformationally-restricted reduced amide dipeptide isosteres
Taylor, G. Mark,Baker, Stewart J.,Gedney, Andrea,Pearson, David J.,Sibley, Graham E. M.
, p. 1297 - 1300 (2007/10/03)
The Ritter reactions of 3-alkyl-3-hydroxyazetidine or -piperidine derivatives give low yields of the desired products, whereas the 3-alkyl-3-hydroxy-pyrrolidine and 4-alkyl-4-hydroxy-piperidine derivatives react smoothly to give the corresponding acetamides. An alternative route to 3-acylamino-3-alkylpiperidines, which were designed as conformationally-restricted reduced amide dipeptide isosteres, was devised from nipecotic acid vai a Hofmann rearrangement.
