180992-33-0

Basic information

• Product Name: 4-(2-Chloro-4-nitrobenzoyl)-5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepine
• Synonyms: 4-(2-Chloro-4-nitrobenzoyl)-5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepine
• CAS NO: 180992-33-0
• Molecular Weight: 336.799
• Mol File: 180992-33-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4-(2-Chloro-4-nitrobenzoyl)-5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-Chloro-4-nitrobenzoyl)-5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepine(180992-33-0)
• EPA Substance Registry System: 4-(2-Chloro-4-nitrobenzoyl)-5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepine(180992-33-0)

Safety Data

• Hazardous Substances Data: 180992-33-0(Hazardous Substances Data)

Upstream product

• 94252-22-9 6,7-dihydro-5H-benzo[b]thiophene-4-one O-tosyloxime 
• 4751-61-5 4,6,7,8-Tetrahydro-4H-thieno[3,2-b]azepin-5-one 
• 19995-19-8 4,5,6,7-tetrahydro-4-oxobenzo[b]thiophene oxime 
• 13414-95-4 4-keto-4,5,6,7-tetrahydrothianaphthene 
• 7073-36-1 2-chloro-4-nitrobenzoyl chloride 
• 180340-57-2 5,6,7,8-tetra-hydro-4H-thieno[3,2-b]azepine 

Downstream Products

• 180992-34-1 4-(2-chloro-4-aminobenzoyl)-5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepine 
• 180339-69-9 4-(2-Chloro-4-nitro-benzoyl)-7-[1-dimethylamino-meth-(E)-ylidene]-4,5,6,7-tetrahydro-thieno[3,2-b]azepin-8-one 
• 276867-98-2 C₁₆H₁₁ClN₄O₃S 
• 276868-00-9 C₁₆H₁₃ClN₄OS 
• 180992-35-2 4,5,6,7-tetrahydro-4-(2-chloro-4-nitrobenzoyl)-8H-thieno[3,2-b]azepin-8-one 

Relevant articles and documents

The synthesis and vasopressin (AVP) antagonist activity of a novel series of N-Aroyl-2,4,5,6-tetrahydropyrazolo-[3,4-d]thieno[3,2-b]azepines

Synthesis and SAR of N-[4-[(4,5-dihydropyrazolo[3,4-d]thieno[3,2-b]azepin-6(2H)-yl)carbonyl]phenyl]be nzamides as arginine vasopressin (AVP) receptor antagonists are discussed. Potent orally active AVP receptor antagonists are produced when the benzamide moiety contains a phenyl group at the 2-position. Similar analogues of 4,6,7,8-tetrahydro-5H-thieno[3,2-b]azepine and VPA-985 are reported. (C) 2000 Elsevier Science Ltd. All rights reserved.

TRICYCLIC THIENO-AZEPINE VASOPRESSIN ANTAGONISTS

This invention relates to new bicyclic non-peptide vasopressin antagonists which are useful in treating conditions where decreased vasopressin levels are desired, such as in congestive heart failure, in disease conditions with excess renal water reabsorption and in conditions with increased vascular resistance and coronary vasoconstriction.