19112-35-7

Basic information

• Product Name: 3-(2-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER
• Synonyms: ETHYL (2-CHLOROBENZOYL)ACETATE;ETHYL 3-(2-CHLORO-PHENYL)-3-OXOPROPANOATE;3-(2-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER;Ethyl (o-chlorobenzoyl)acetate;NSC 158136;Ethyl (2-chlorobenzoyl)acetate >=95%
• CAS NO: 19112-35-7
• Molecular Formula: C₁₁H₁₁ClO₃
• Molecular Weight: 226.66
• Product Categories: C10 to C11;Carbonyl Compounds;Esters
• Mol File: 19112-35-7.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 221-222 °C(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.206 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.00387mmHg at 25°C
• Refractive Index: n20/D 1.540(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 9.85±0.46(Predicted)
• CAS DataBase Reference: 3-(2-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER(19112-35-7)
• EPA Substance Registry System: 3-(2-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER(19112-35-7)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 19112-35-7(Hazardous Substances Data)

Usage

Uses

Reactant for:Cerium ammonium nitrate-mediated oxidative couplingHydrosilylation reactionsPreparation of diaryl-substituted pyrazoles as potent CCR2 receptor antagonistsPreparation of potential herbicidal agentsRuthenium-catalyzed asymmetric hydrogenation

InChI:InChI=1/C11H11ClO3/c1-2-15-11(14)7-10(13)8-5-3-4-6-9(8)12/h3-6H,2,7H2,1H3

Upstream product

• 1071-46-1 hydrogen ethyl malonate 
• 609-65-4 o-chlorobenzoyl chloride 
• 3516-73-2 2-Chlor-benzoyl-malonsaeure-diethylester 
• 74476-71-4 ethyl 2-(2-chlorobenzoyl)-3-oxobutanoate 
• 141-97-9 ethyl acetoacetate 
• 37517-78-5 magnesium bis(3-ethoxy-3-oxopropanoate) 
• 118-91-2 ortho-chlorobenzoic acid 
• 2142-68-9 1-(2-chlorophenyl)ethanone 
• 105-58-8 Diethyl carbonate 
• 1336-21-6 ammonium hydroxide 
• 89-98-5 2-chloro-benzaldehyde 
• 141-78-6 ethyl acetate 
• 6148-64-7 ethyl potassium malonate 
• 67333-74-8 1-(2-chloro-benzoyl)-1H-imidazole 

Downstream Products

• 92425-79-1 1-(2-chloro-phenyl)-4-[2]pyridyl-butan-1-one 
• 107327-81-1 3-(2-chloro-benzoyl)-8-methoxy-coumarin 
• 100710-05-2 2-(2-chloro-phenyl)-5,6-dihydro-4H-pyran-3-carboxylic acid ethyl ester 
• 101422-34-8 6-chloro-3-(2-chloro-benzoyl)-coumarin 
• 130907-50-5 3-(2-chloro-benzoyl)-7-hydroxy-coumarin 
• 101422-20-2 3-(2-chloro-benzoyl)-6,8-diiodo-coumarin 
• 101422-19-9 6,8-dibromo-3-(2-chloro-benzoyl)-coumarin 
• 133525-42-5 5-amino-2-(2-chloro-phenyl)-8-methyl-thiochromen-4-one 
• 2142-68-9 1-(2-chlorophenyl)ethanone 
• 56851-04-8 5-(2-chloro-phenyl)-3-pyridin-4-yl-isoxazole-4-carboxylic acid ethyl ester 
• 50671-02-8 α-(2-Chlorbenzoyl)-2-methoxy-5-nitroacetanilid 
• 50671-21-1 α-(2-Chlorbenzoyl)-2-methyl-5-lauroylacetanilid 
• 50671-10-8 2-Cetoxy-α-(2-chlorbenzoyl)-acetanilid 
• 50671-17-5 α-(2-Chlorbenzoyl)-5--2-methoxyacetanilid 

Relevant articles and documents

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Synthesis of Dithiolethiones and Identification of Potential Neuroprotective Agents via Activation of Nrf2-Driven Antioxidant Enzymes

Oxidative stress is implicated in the pathogenesis of a wide variety of neurodegenerative disorders, and accordingly, dietary supplement of exogenous antioxidants or/and upregulation of the endogenous antioxidant defense system are promising for therapeutic intervention or chemoprevention of neurodegenerative diseases. Nrf2, a master regulator of the cellular antioxidant machinery, cardinally participates in the transcription of cytoprotective genes against oxidative/electrophilic stresses. Herein, we report the synthesis of 59 structurally diverse dithiolethiones and evaluation of their neuroprotection against 6-hydroxydopamine-or H2O2-induced oxidative damages in PC12 cells, a neuron-like rat pheochromocytoma cell line. Initial screening identified compounds 10 and 11 having low cytotoxicity but conferring remarkable protection on PC12 cells from oxidative-mediated damages. Further studies demonstrated that both compounds upregulated a battery of antioxidant genes as well as corresponding genes' products. Significantly, silence of Nrf2 expression abolishes cytoprotection of 10 and 11, indicating targeting Nrf2 activation is pivotal for their cellular functions. Taken together, the two lead compounds discovered here with potent neuroprotective functions against oxidative stress via Nrf2 activation merit further development as therapeutic or chemopreventive candidates for neurodegenerative disorders.

White mulberry root-bark active ingredient Morusin derivative and application and preparation method thereof

The invention discloses a Morusin derivative and a preparation method. A Morusin total-synthesis route is adopted to achieve a structure modification scheme, in the process of Morusin total synthesis, structure modification is carried out by replacing sub