22135-53-1

Basic information

• Product Name: 1-(4-Bromophenyl)-butanol
• Synonyms: 4-bromo-alpha-propylbenzyl alcohol;4-Bromo-α-propylbenzenemethanol;Einecs 244-801-5;1-(4-bromophenyl)-1-butanol(SALTDATA: FREE);DL-4-BROMO-ALPHA-PROPYLBENZYL ALCOHOL;1-(4-bromophenyl)butan-1-ol
• CAS NO: 22135-53-1
• Molecular Formula: C₁₀H₁₃BrO
• Molecular Weight: 229.11362
• EINECS: 244-801-5
• Mol File: 22135-53-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 304.4°Cat760mmHg
• Flash Point: 137.9°C
• Appearance: /
• Density: 1.35g/cm³
• Vapor Pressure: 0.000386mmHg at 25°C
• Refractive Index: 1.552
• PKA: 14.22±0.20(Predicted)
• CAS DataBase Reference: 1-(4-Bromophenyl)-butanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-Bromophenyl)-butanol(22135-53-1)
• EPA Substance Registry System: 1-(4-Bromophenyl)-butanol(22135-53-1)

Safety Data

• Hazardous Substances Data: 22135-53-1(Hazardous Substances Data)

Usage

General Description

1-(4-Bromophenyl)-butanol is a chemical compound with the molecular formula C10H13BrO. It is a white to off-white solid with a molecular weight of 227.11 g/mol. 1-(4-Bromophenyl)-butanol is classified as an alcohol and contains a phenyl group and a bromine atom. It is used in organic synthesis and as a pharmaceutical intermediate. It has potential applications in the field of medicine and biochemistry, where it can be used to study biological systems and develop new medications. Additionally, it may also be used in the manufacturing of various products such as perfumes, flavors, and fragrances. Overall, 1-(4-Bromophenyl)-butanol has various potential uses in the chemical and pharmaceutical industries.

InChI:InChI=1/C10H13BrO/c1-2-3-10(12)8-4-6-9(11)7-5-8/h4-7,10,12H,2-3H2,1H3

Upstream product

• 927-77-5 n-propylmagnesium bromide 
• 1122-91-4 4-bromo-benzaldehyde 
• 41492-05-1 p-bromobutylbenzene 
• 106-94-5 propyl bromide 
• 123-72-8 butyraldehyde 
• 18620-02-5 (4-bromophenyl)magnesium bromide 

Downstream Products

• 162174-54-1 1-Bromo-1-(4'-bromophenyl)-butane 
• 76287-43-9 Tris-(4-butyl-phenyl)-phosphane 
• 41492-05-1 p-bromobutylbenzene 
• 75906-36-4 4-(p-bromophenyl)-butan-1-ol 
• 98453-57-7 4-(4-bromophenyl)butanoic acid methyl ester 
• 35656-89-4 4-(4-bromophenyl)butanoic acid 
• 74532-94-8 1-bromo-4-(but-1-en-1-yl)benzene 
• 490035-78-4 (E)-1-bromo-4-(but-1-en-1-yl)benzene 

Relevant articles and documents

Synthesis of Benzylic Alcohols by C-H Oxidation

Selective methylene C-H oxidation for the synthesis of alcohols with a broad scope and functional group tolerance is challenging due to the high proclivity for further oxidation of alcohols to ketones. Here, we report the selective synthesis of benzylic alcohols employing bis(methanesulfonyl) peroxide as an oxidant. We attempt to provide a rationale for the selectivity for monooxygenation, which is distinct from previous work; a proton-coupled electron transfer mechanism (PCET) may account for the difference in reactivity. We envision that our method will be useful for applications in the discovery of drugs and agrochemicals.

Tandem α-Alkylation/Asymmetric Transfer Hydrogenation of Acetophenones with Primary Alcohols

Tandem α-alkylation/asymmetric transfer hydrogenation of acetophenones with primary alcohols, mediated by a single ruthenium catalyst, is described. Under optimized reaction conditions and with use of [Ru(p-cymene)Cl2]2 in combination with an amino acid hydroxyamide ligand, the chiral secondary alcohol products were isolated in moderate yields and in moderate to good enantiomeric excess (up to 89 % ee). One catalyst - one pot - two reactions. Acetophenones are initially alkylated with primary alcohols by the borrowing hydrogen methodology. The alkylation products are directly converted to enantiomerically enriched secondary alcohols.

Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating hyperplasia and other diseases

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