23735-39-9

Basic information

• Product Name: 2,2-DIMETHYL-4(R)-4-IODOMETHYL-1,3-DIOXALANE
• Synonyms: 2,2-DIMETHYL-4(R)-4-IODOMETHYL-1,3-DIOXALANE;(4R)-4-(IODOMETHYL)-2 2-DIMETHYL-1 3-DI&;(4R)-2,2-Dimethyl-4-iodomethyl-1,3-dioxolane;(4R)-4-(lodomethyl)-2,2-dimethyl-1,3-dioxolane
• CAS NO: 23735-39-9
• Molecular Formula: C₆H₁₁IO₂
• Molecular Weight: 242.05
• Mol File: 23735-39-9.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 217.3°Cat760mmHg
• Flash Point: 85.2°C
• Appearance: /
• Density: 1.623g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 2,2-DIMETHYL-4(R)-4-IODOMETHYL-1,3-DIOXALANE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-DIMETHYL-4(R)-4-IODOMETHYL-1,3-DIOXALANE(23735-39-9)
• EPA Substance Registry System: 2,2-DIMETHYL-4(R)-4-IODOMETHYL-1,3-DIOXALANE(23735-39-9)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 23735-39-9(Hazardous Substances Data)

Usage

General Description

2,2-DIMETHYL-4(R)-4-IODOMETHYL-1,3-DIOXALANE, also known as iodomethylidene 1,3-dioxolane, is a chemical compound with the molecular formula C6H9IO2. It is a colorless liquid with a molecular weight of 230.04 g/mol. 2,2-DIMETHYL-4(R)-4-IODOMETHYL-1,3-DIOXALANE is used as a reagent in organic synthesis and pharmaceutical research, specifically as a building block for the synthesis of complex organic molecules. It is also used in the production of pharmaceuticals and agrochemicals. 2,2-DIMETHYL-4(R)-4-IODOMETHYL-1,3-DIOXALANE is considered to be potentially hazardous if mishandled, as it is a reactive chemical and should be handled with care in a controlled environment.

Upstream product

• 23788-74-1 (R)-2,2-dimethyl-1,3-dioxolane-4-ylmethyl p-toluenesulfonate 
• 22323-82-6 (S)-(+)-(2,2-dimethyl-[1,3]dioxolan-4-yl)methanol 
• 15186-48-8 2,3-isopropylidene-glyceraldehyde 
• 14347-78-5 1,2-O-isopropylidene-D-glycerol 
• 1707-77-3 1,2:5,6-di-O-isopropylidene-D-mannitol 
• 83461-40-9 methanesulfonic acid (R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester 

Downstream Products

• 144042-75-1 3-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-diphenyl-propionic acid 
• 82954-65-2 [(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methanamine 
• 85820-82-2 (S)-1-azido-1-deoxy-2,3-O-isopropylidene-glycerol 
• 881993-61-9 C₁₆H₂₃NO₇S 
• 396092-17-4 (5S)-5,6-(dimethylmethylene)dioxy-2-methylhex-1-en-3-yl phenyl sulfone 
• 276238-64-3 2-benzenesulfonyl-3-(2,2-dimethyl-[1,3]dioxolan-4-yl)-N-methoxy-N-methyl-propionamide 
• 220133-88-0 (4S)-4-<2,2-bis(benzoxycarbonyl)ethyl>-2,2-dimethyl-1,3-dioxolane 

Relevant articles and documents

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Design, Synthesis, and Preliminary Immunological Studies of MUC1-Based Antitumor Vaccines Adjuvanted with R- And S-FSL-1

Fibroblast stimulating lipopeptide 1 (FSL-1) is the ligand of TLR2 and TLR6 and can be used as the vaccine adjuvant to prepare antitumor vaccines. However, FSL-1 is a stereoisomeric mixture that contains the R stereoisomer and S stereoisomer, and it is still unclear which stereoisomer has better adjuvant activities. In this work, we designed and synthesized MUC1-based antitumor vaccines adjuvanted with the stereoisomers R-FSL-1 and S-FSL-1, which were synthesized from the stereoisomeric building blocks R-Fmoc-Pam2Cys-OH and S-Fmoc-Pam2Cys-OH, respectively. Immunological evaluation indicated that both R-FSL-1 and S-FSL-1 can be used as adjuvants for the construction of MUC1-based antitumor vaccines, with R-FSL-1 showing a better adjuvant effect than S-FSL-1.

Synthesis of non-hydrolysable mimics of glycosylphosphatidylinositol (GPI) anchors

Synthesis of first generation non-hydrolysable C-phosphonate GPI analogs, viz., 6-O-(2-amino-2-deoxy-α-d-glucopyranosyl)-d-myo-inositol-1-O-(sn-3,4- bis(palmitoyloxy)butyl-1-phosphonate) 23a and 6-O-(2-amino-2-deoxy-α-d- glucopyranosyl)-d-myo-inositol-1-O-(sn-2,3-bis(palmitoyloxy)propyl-1- phosphonate) 23b, is reported. The target compounds were synthesized by the coupling of α-pseudodisaccharide 21 with phosphonic acids 18a and 18b respectively in quantitative yield followed by de-protection. These synthetic C-phosphonate GPI-probes were resistant to phosphatidylinositol specific phospholipase C (PI-PLC) and also showed moderate inhibition of the enzyme activity. The Royal Society of Chemistry.