82954-65-2

Basic information

• Product Name: (S)-(+)-(2,2-DIMETHYL-[1,3]-DIOXOLAN-4-YL)-METHYLAMINE
• Synonyms: (S)-(+)-(2,2-DIMETHYL-[1,3]-DIOXOLAN-4-YL)-METHYLAMINE;(S)-3-AMINO-1,2-DIHYDROXYPROPANE ISOPROPYLIDENE ACETAL;(S)-4-AMINOMETHYL-2,2-DIMETHYL-1,3-DIOXOLANE;1,3-DIOXOLANE-4-METHANAMINE, 2,2-DIMETHYL-, (S);(4S)-2 2-DIMETHYL-1 3-DIOXOLANE-4-METHA&;(S)-(+)-(2,2-Dimethyl-[1,3]-dioxolan-4-yl)-;(4S)-2,2-Dimethyl-1,3-dioxolane-4-methanamine;(4S)-2,2-Dimethyl-4-aminomethyl-1,3-dioxolane
• CAS NO: 82954-65-2
• Molecular Formula: C₆H₁₃NO₂
• Molecular Weight: 131.17
• Mol File: 82954-65-2.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 147-148°C/14mm
• Flash Point: 57.6 °C
• Appearance: /
• Density: 1.012
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: (S)-(+)-(2,2-DIMETHYL-[1,3]-DIOXOLAN-4-YL)-METHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(+)-(2,2-DIMETHYL-[1,3]-DIOXOLAN-4-YL)-METHYLAMINE(82954-65-2)
• EPA Substance Registry System: (S)-(+)-(2,2-DIMETHYL-[1,3]-DIOXOLAN-4-YL)-METHYLAMINE(82954-65-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22-37/38-41-43
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 82954-65-2(Hazardous Substances Data)

Usage

General Description

(S)-(+)-(2,2-DIMETHYL-[1,3]-DIOXOLAN-4-YL)-METHYLAMINE, also known as (S)-(+)-DMDOA, is a chemical compound with the molecular formula C6H13NO2. It is a chiral amine with a dioxolane ring structure, and it is commonly used as a reagent in organic synthesis. (S)-(+)-(2,2-DIMETHYL-[1,3]-DIOXOLAN-4-YL)-METHYLAMINE is typically used as a resolving agent for chiral acids and as a catalyst in various chemical reactions. (S)-(+)-(2,2-DIMETHYL-[1,3]-DIOXOLAN-4-YL)-METHYLAMINE has potential applications in pharmaceuticals and agrochemicals, and it is important in the research and development of new drugs and other bioactive compounds. Due to its chiral nature, it is essential for the production of enantiopure compounds, which have important applications in the fields of medicine and biotechnology.

Upstream product

• 117465-48-2 (S)-2,2-dimethyl-1,3-dioxolane-4-carbaldehyde oxime 
• 109208-40-4 N-benzyl-N-amine 
• 40137-25-5 1H-isoindole-1,3(2H)-dione, 2-[[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl] 
• 23735-39-9 (R)-4-(iodomethyl)-2,2-dimethyl-1,3-dioxolane 
• 83461-40-9 methanesulfonic acid (R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester 
• 22323-82-6 (S)-(+)-(2,2-dimethyl-[1,3]dioxolan-4-yl)methanol 
• 5469-16-9 4-Hydroxy-dihydro-furan-2-on 
• 77-76-9 2,2-dimethoxy-propane 
• 23788-74-1 (R)-2,2-dimethyl-1,3-dioxolane-4-ylmethyl p-toluenesulfonate 
• 1707-77-3 1,2:5,6-di-O-isopropylidene-D-mannitol 
• 15186-48-8 2,3-isopropylidene-glyceraldehyde 
• 185996-33-2 (S)-4-(2,2-dimethyl)-1,3-dioxolane acetamide 
• 85820-82-2 (S)-1-azido-1-deoxy-2,3-O-isopropylidene-glycerol 

Downstream Products

• 134038-71-4 (S)-4-benzyloxycarbonylaminomethyl-2,2-dimethyl-1,3-dioxolane 
• 61278-21-5 (S)-3-Amino-1,2-propanediol 
• 1161881-57-7 (2E)-1-({[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl}amino)-3-{[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methoxy}propanone O-benzyloxime 
• 1161881-58-8 (2Z)-1-({[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl}amino)-3-({[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl}thio)propanone O-benzyloxime 
• 14437-88-8 (2R)-3-bromo-1,2-propanediol 
• 57090-45-6 (2R)-3-chloro-1,2-propanediol 
• 851303-51-0 C₁₈H₂₆N₂O₅ 

Relevant articles and documents

Stereochemistry-Controlled Supramolecular Architectures of New Tetrahydroxy-Functionalised Amphiphilic Carbocyanine Dyes

The syntheses of novel amphiphilic 5,5′,6,6′-tetrachlorobenzimidacarbocyanine (TBC) dye derivatives with aminopropanediol head groups, which only differ in stereochemistry (chiral enantiomers, meso form and conformer), are reported. For the achiral meso form, a new synthetic route towards asymmetric cyanine dyes was established. All compounds form J aggregates in water, the optical properties of which were characterised by means of spectroscopic methods. The supramolecular structure of the aggregates is investigated by means of cryo-transmission electron microscopy, cryo-electron tomography and AFM, revealing extended sheet-like aggregates for chiral enantiomers and nanotubes for the mesomer, respectively, whereas the conformer forms predominately needle-like crystals. The experiments demonstrate that the aggregation behaviour of compounds can be controlled solely by head group stereochemistry, which in the case of enantiomers enables the formation of extended hydrogen-bond chains by the hydroxyl functionalities. In case of the achiral meso form, however, such chains turned out to be sterically excluded.

Synthesis of phosphonoglycine backbone units for the development of phosphono peptide nucleic acids

A series of phosphono-modified backbone mimics based on achiral and chiral N-(dihydroxypropyl)glycine units were obtained by sequential addition of phosphonate and nucleobase moieties to suitably protected dihydroxypropylamines. Simple synthetic strategies enabled the preparation of various target derivatives that will be useful as building blocks for the preparation of new synthetic polymers containing a phosphonate internucleotide linkage in place of the standard phosphodiester bond. Copyright

ACYCLIC AMINE INHIBITORS OF 5'-METHYLTHIOADENOSINE PHOSPHORYLASE AND NUCLEOSIDASE

The present invention relates to compounds of the general formula (I) which are inhibitors of 5'-methylthioadenosine phosphorylase or 5'-methylthioadenosine nucleosidase. The invention also relates to the use of these compounds in the treatment of diseases or conditions in which it is desirable to inhibit 5'-methylthioadenosine phosphorylase or 5'-methylthioadenosine nucleosidase including cancer, and to pharmaceutical compositions containing the compounds.