244277-90-5

Basic information

• Product Name: (2R,5R)-2-(tert-butyl)-5-phenyl-5-cyclopentyl-1,3-dioxolan-4-one
• Synonyms: (2R,5R)-2-(tert-butyl)-5-phenyl-5-cyclopentyl-1,3-dioxolan-4-one
• CAS NO: 244277-90-5
• Molecular Weight: 288.387
• Mol File: 244277-90-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2R,5R)-2-(tert-butyl)-5-phenyl-5-cyclopentyl-1,3-dioxolan-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,5R)-2-(tert-butyl)-5-phenyl-5-cyclopentyl-1,3-dioxolan-4-one(244277-90-5)
• EPA Substance Registry System: (2R,5R)-2-(tert-butyl)-5-phenyl-5-cyclopentyl-1,3-dioxolan-4-one(244277-90-5)

Safety Data

• Hazardous Substances Data: 244277-90-5(Hazardous Substances Data)

Upstream product

• 116907-30-3 (2R,5R)-2-(tert-butyl)-5-phenyl-1,3-dioxolan-4-one 
• 630-19-3 pivalaldehyde 
• 611-71-2 (R)-Mandelic Acid 
• 909298-90-4 (2R,5S)-2-(tert-butyl)-5-phenyl-5-(1-hydroxycyclopentyl)-1,3-dioxolan-4-one 
• 910099-85-3 (2R,5S)-2-(tert-butyl)-5-phenyl-5-(cyclopent-1-enyl)-1,3-dioxolan-4-one 

Downstream Products

• 64471-47-2 (R)-α-phenyl-α-cyclopentyl-α-hydroxyacetate methyl ester 
• 64471-45-0 (2R)-2-cyclopentyl-2-hydroxy-2-phenylacetic acid 

Relevant articles and documents

Stereoselective synthesis of the optical isomers of a new muscarinic receptor antagonist, HL-031120

We present here a practical stereoselective synthetic method to produce enantiopure isomers of a new muscarinic receptor antagonist, HL-031120 (3-quinuclidinyl-2′-cyclopentyl-2′-hydroxy-2′-phenylacetate, I). Four optical isomers were effectively by stereoselective synthesized using pivaldehyde as steric hindrance agent from the chiral starting material, ( S ) or ( R )-mandelic acid. The isomers were obtained with 70-76% yields in 98-99% e.e. Copyright Taylor & Francis Group, LLC.