909298-90-4Relevant articles and documents
Stereoselective synthesis of the optical isomers of a new muscarinic receptor antagonist, HL-031120
Liu, Yu-Min,Liu, He,Zhong, Bo-Hua,Liu, Ke-Liang
, p. 1815 - 1822 (2006)
We present here a practical stereoselective synthetic method to produce enantiopure isomers of a new muscarinic receptor antagonist, HL-031120 (3-quinuclidinyl-2′-cyclopentyl-2′-hydroxy-2′-phenylacetate, I). Four optical isomers were effectively by stereoselective synthesized using pivaldehyde as steric hindrance agent from the chiral starting material, ( S ) or ( R )-mandelic acid. The isomers were obtained with 70-76% yields in 98-99% e.e. Copyright Taylor & Francis Group, LLC.
A quaternary ammonium salt of pentethyl quinamidine optical isomer, pharmaceutical composition and its medical use
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, (2017/02/24)
The invention relates to a quaternary ammonium salt compound shown as a formula I, or pharmaceutically acceptable salt or solvate thereof. The invention also relates to application of the compound as a selective M receptor antagonist, particularly a selec
AMIDINE-CONTAINING COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS
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Page/Page column 17, (2009/07/17)
The invention relates to compounds of formula I: or a pharmaceutically acceptable salt thereof, where R1-3, R5, R7, a, b, Q, X, X′, X″, Y, Z, and Ar are as defined in the specification. These compounds are muscarinic recep