64471-47-2

Basic information

• Product Name: (R)-α-phenyl-α-cyclopentyl-α-hydroxyacetate methyl ester
• Synonyms: (R)-α-phenyl-α-cyclopentyl-α-hydroxyacetate methyl ester
• CAS NO: 64471-47-2
• Molecular Weight: 234.295
• Mol File: 64471-47-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (R)-α-phenyl-α-cyclopentyl-α-hydroxyacetate methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-α-phenyl-α-cyclopentyl-α-hydroxyacetate methyl ester(64471-47-2)
• EPA Substance Registry System: (R)-α-phenyl-α-cyclopentyl-α-hydroxyacetate methyl ester(64471-47-2)

Safety Data

• Hazardous Substances Data: 64471-47-2(Hazardous Substances Data)

Usage

Description

(R)-α-phenyl-α-cyclopentyl-α-hydroxyacetate methyl ester is a chiral ester compound characterized by the presence of a methyl ester group, a hydroxyacetate moiety, and a cyclopentyl ring, along with a phenyl group. The (R) designation denotes a specific spatial arrangement of atoms at the chiral center, which may influence its reactivity and applications.

Uses

Used in Organic Synthesis:
(R)-α-phenyl-α-cyclopentyl-α-hydroxyacetate methyl ester is used as an intermediate in the synthesis of various organic compounds due to its unique structural features and potential reactivity.
Used in Pharmaceutical Industry:
(R)-α-phenyl-α-cyclopentyl-α-hydroxyacetate methyl ester is used as a building block for the development of new pharmaceuticals, leveraging its chiral center and diverse functional groups to create novel drug candidates with potential therapeutic applications.
Used in Chemical Research:
(R)-α-phenyl-α-cyclopentyl-α-hydroxyacetate methyl ester serves as a subject of study in chemical research, where its properties, reactivity, and potential applications are explored to expand the understanding of ester chemistry and its role in various chemical processes.
Used in the Flavor and Fragrance Industry:
(R)-α-phenyl-α-cyclopentyl-α-hydroxyacetate methyl ester may be utilized as a component in the creation of unique fragrances and flavors, taking advantage of its specific molecular structure to contribute to the sensory characteristics of products in this industry.

Upstream product

• 67-56-1 methanol 
• 64471-45-0 (2R)-2-cyclopentyl-2-hydroxy-2-phenylacetic acid 
• 185030-09-5 (R)-α-(cyclopentyl-1-ene)-α-hydroxyl-α-phenylacetic acid 
• 116907-30-3 (2R,5R)-2-(tert-butyl)-5-phenyl-1,3-dioxolan-4-one 
• 611-71-2 (R)-Mandelic Acid 
• 244277-90-5 (2R,5R)-2-(tert-butyl)-5-phenyl-5-cyclopentyl-1,3-dioxolan-4-one 
• 909298-90-4 (2R,5S)-2-(tert-butyl)-5-phenyl-5-(1-hydroxycyclopentyl)-1,3-dioxolan-4-one 
• 910099-85-3 (2R,5S)-2-(tert-butyl)-5-phenyl-5-(cyclopent-1-enyl)-1,3-dioxolan-4-one 
• 186581-53-3 diazomethane 
• 90581-53-6 (2S,5S)-2,5-diphenyl-1,3-dioxolan-4-one 
• 17199-29-0 (S)-Mandelic acid 
• 137-43-9 Cyclopentyl bromide 

Downstream Products

• 873912-87-9 N-methyl-3-pyrrolidinyl (-)-cyclopentylmandelate 
• 230313-75-4 (R)-N-methyl-3-azabicyclo[3,3,1]nonan-9-yl 2'-cyclopentyl-2'-hydroxy-2'-phenylacetate 
• 616866-21-8 (2R,3'R)-3'-(2-cyclopentyl-2-hydroxy-2-phenylacetoxy)-1'-methylpyrrolidine 
• 1318114-57-6 (1R,2S)-2-((R)-2'-cyclopentyl-2'-hydroxy-2'-phenylacetoxy)-7,7-dimethyl-7-azoniabicyclo [2.2.1]heptane bromide 
• 1318115-18-2 (1R,2S)-2-((R)-2'-cyclopentyl-2'-hydroxy-2'-phenylacetoxy)-7-methyl-7-azabicyclo[2.2.1]heptane 
• 1318115-20-6 C₁₉H₂₅NO₃ 
• 1318115-02-4 (1R,2S)-2-((R)-2'-cyclopentyl-2'-hydroxy-2'-phenylacetoxy)-7-(tert-butoxycarbonyl)-7-azabicyclo[2.2.1]heptane 

Relevant articles and documents

Preparation method of levo-demethyl benzene ring nonyl ester hydrochloride

The invention belongs to the technical field of medicine preparation, and discloses a preparation method of levo-demethylated benzene ring nonyl ester hydrochloride, the molecular formula of the levo-demethylated benzene ring nonyl ester hydrochloride is shown as (1), the method comprises the following steps: (1) preparing (R)-alpha-phenyl-alpha-cyclopentyl-alpha-methyl glycolate; (2) preparing anintermediate, wherein the intermediate is N-benzyl-3-azabicyclo-[3.3. 1]-non-9 [alpha]-alcohol; and (3) carrying out transesterification on the (R)-alpha-phenyl-alpha-cyclopentyl-alpha-methyl glycolate and N-benzyl-3-azabicyclo-[3.3. 1]-non-9 alpha-ol, removing benzyl on N through catalytic hydrogenation to obtain a crude product of L-demethyl benzene ring nonyl ester, salifying, and recrystallizing to obtain the L-hydrochloric acid demethyl benzene ring nonyl ester. The method is environmentally friendly and suitable for large-scale production.

Stereoselective synthesis of the optical isomers of a new muscarinic receptor antagonist, HL-031120

We present here a practical stereoselective synthetic method to produce enantiopure isomers of a new muscarinic receptor antagonist, HL-031120 (3-quinuclidinyl-2′-cyclopentyl-2′-hydroxy-2′-phenylacetate, I). Four optical isomers were effectively by stereoselective synthesized using pivaldehyde as steric hindrance agent from the chiral starting material, ( S ) or ( R )-mandelic acid. The isomers were obtained with 70-76% yields in 98-99% e.e. Copyright Taylor & Francis Group, LLC.