2459-05-4Relevant articles and documents
Action of alpha-chymotrypsin on the diethyl esters of fumaric, maleic, and acetylenedicarboxylic acids.
Cohen,Klee,Weinstein
, p. 5302 - 5305 (1966)
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Kras-G12C inhibitor heterocyclic compounds
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Paragraph 0239; 0242-0245, (2021/06/23)
The invention relates to Kras-G12C inhibitor heterocyclic compounds represented by formula I, a preparation method thereof, and application of the Kras-G12C inhibitor heterocyclic compounds in prevention and treatment of tumor diseases such as lung cancer, colorectal cancer and pancreatic cancer. In the preparation process, the compounds of the general formula I are obtained through a series of reactions such as SN2 reaction, protection, coupling reaction, deprotection, condensation reaction and the like.
A comparative study on degradation of complex malathion organophosphate using of Escherichia coli IES-02 and a novel carboxylesterase
Ansari, Asma,Iqbal, Sajid,Khan, Moazzam Ali,Qader, Shah Ali Ul,Sattar, Hafsa,Sirajuddin, Sadia
, p. 445 - 455 (2020/01/08)
Malathion organophosphates considered as the major constituent of herbicides, pesticides and insecticides. Extensively used in agricultural, horticultures and for numerous household applications contributes to precedence organic pollutants leading antagonistic effects on human health and environment. Therefore detoxification of malathion from contaminated site is of general interest. Simultaneously it is very emerging to isolated novel indigenous microbial strains from contaminated site with a record of pesticide application. In this study Escherichia coli IES-02 isolated from malathion contaminant effluent and the strain showed maximum efficiency in malathion degradation that utilized it as the sole source of carbon. Carboxylesterase (33.0, 30.0, 28.0 kDa) were purified (1685.71 U/mg) from Escherichia coli IES-02 showed significant results in malathion degradation approximately 81% within 20 min as compared with Escherichia coli IES-02 cells within 4 h (99.0 to 95.0%) into monocarboxylic acid and diacid derivatives. The generation time of Escherichia coli was also observed at 60 min with 0.1 ppm, 68 min with 0.5 ppm, 74.5 min with 2.0 ppm and 91.37 min with 50 ppm of malathion. The degradation rate and transformation metabolites were estimated by Gas Chromatography-Mass Spectrometry respectively. Malathion metabolites pathway proposed in this study which revealed the potential application against lethal environmental pollution.
Application of fumaric acid monoethyl ester silver salt in preventing novel coronavirus infections
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Paragraph 0022, (2020/06/09)
The invention discloses application of fumaric acid monoethyl ester silver salt in preventing novel coronavirus infections. The application comprises the following steps: adding 1000g of fumaric acidmonoethyl ester into a reaction bottle of 5L, adding 3Kg of pure water, adding 100g of nano silver oxide while stirring, performing a stirring reaction for 9 hours, filtering the reaction liquid to remove impurities, performing vacuum distillation to spin off moisture at 60 DEG C, adding 5Kg of ethanol, performing stirring crystallization for 4.5 hours, performing filtering, collecting a solid, and performing vacuum drying on the obtained solid for 6 hours at 75 DEG C, so as to obtain the fumaric acid monoethyl ester silver salt. The fumaric acid monoethyl ester silver salt is applied to treatment and prevention on various coronaviruses. Experiments show that with a concentration of 500[mu] g/mL, a fumaric acid monoethyl ester silver salt dissolved solution has an inhibition rate of 99.9%upon coronavirus main protease, a corresponding zinc salt dissolved solution and a silver salt dissolved solution of the fumaric acid monoethyl ester silver salt have inhibition rates of 99.9% and 99.7% upon the coronavirus main protease respectively, and the effects are remarkable.