25989-85-9

Basic information

• Product Name: 1H-Pyrrole-2,5-dione,1-(4-methylphenyl)-, homopolymer (9CI)
• Synonyms: Maleimide, N-p-tolyl-, polymers(8CI); N-(4-Methylphenyl)maleimide homopolymer; N-(4-Methylphenyl)maleimidepolymer; N-(p-Methylphenyl)maleimidehomopolymer; N-p-Tolylmaleimidepolymer; Poly(N-p-tolylmaleimide); Poly[N-(4-methylphenyl)maleimide]; Poly[N-(p-methylphenyl)maleimide]; p-Tolylmaleimide polymers
• CAS NO: 25989-85-9
• Molecular Formula: C₁₁H₉NO₂
• Molecular Weight: 187.1947
• Mol File: 25989-85-9.mol
• Article Data: 55

Chemical Properties

• Boiling Point: 333.2°Cat760mmHg
• Flash Point: 154.2°C
• Density: 1.277g/cm³
• CAS DataBase Reference: 1H-Pyrrole-2,5-dione,1-(4-methylphenyl)-, homopolymer (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole-2,5-dione,1-(4-methylphenyl)-, homopolymer (9CI)(25989-85-9)
• EPA Substance Registry System: 1H-Pyrrole-2,5-dione,1-(4-methylphenyl)-, homopolymer (9CI)(25989-85-9)

Safety Data

• Hazardous Substances Data: 25989-85-9(Hazardous Substances Data)

Usage

General Description

1H-Pyrrole-2,5-dione,1-(4-methylphenyl)-, homopolymer (9CI) is a chemical compound that is a homopolymer of 1-(4-methylphenyl)-1H-pyrrole-2,5-dione. It is essentially a polymer made up of repeating units of the monomer 1-(4-methylphenyl)-1H-pyrrole-2,5-dione. This chemical is commonly used in the production of various products such as plastics, adhesives, and coatings due to its high thermal stability and electrical conductivity. It is also known for its excellent resistance to harsh environmental conditions, making it suitable for a wide range of industrial applications.

Upstream product

• 37904-03-3 3-p-tolylcarbamoyl-acrylic acid 
• 108-31-6 maleic anhydride 
• 106-49-0 p-toluidine 
• 38046-98-9 3-chloro-1-(4-methylphenyl)pyrrolidine-2,5-dione 
• 65344-80-1 methyl p-methylmaleanilate 
• 3052-50-4 monomethyl maleate 
• 15485-32-2 N-(4-chlorobenzylidene)-4-toluidine 
• 2272-45-9 benzal-p-toluidine 
• 24870-11-9 4-methylmaleanilic acid 
• 541-59-3 maleiimide 
• 557-24-4 maleamic acid 
• 55818-45-6 methyltriphenylphosphonium 4-methylbenzenesulfonate 
• 67-56-1 methanol 

Downstream Products

• 78817-63-7 5-Acetyl-4-phenyl-2-p-tolyl-3a,11c-dihydro-4H-6-oxa-2,11b-diaza-cyclopenta[c]phenanthrene-1,3,7-trione 
• 97406-83-2 1-(4-nitro-phenyl)-5-p-tolyl-3a,6a-dihydro-1H-pyrrolo[3,4-d][1,2,3]triazole-4,6-dione 
• 91199-17-6 exo-1,2,3,4-Tetrahydro-N-(4-methylphenyl)-1,4-imino-2,3-naphthalindicarboximid 
• 91129-13-4 endo-1,2,3,4-Tetrahydro-N-(4-methylphenyl)-1,4-imino-2,3-naphthalindicarboximid 
• 79326-70-8 4-[5-Oxo-1-p-tolyl-1,5-dihydro-pyrrol-(2Z)-ylidene]-1-phenyl-pyrazolidine-3,5-dione 
• 93518-61-7 1-p-Tolyl-pyrrole-2,5-dione; compound with 1,2,3,4,5,6-hexamethyl-benzene 
• 20929-51-5 4,7-Diphenyl-2-p-tolyl-3a,4,7,7a-tetrahydro-isoindole-1,3-dione 
• 80310-43-6 C₄₃H₃₄N₂O₅ 
• 80310-48-1 C₂₆H₁₇NO₂ 
• 80310-32-3 C₃₇H₃₀N₂O₄ 
• 80310-51-6 C₃₁H₁₉NO₂ 
• 80310-38-9 C₄₂H₃₂N₂O₄ 
• 77395-56-3 1,7,8,9,10,10-Hexabromo-4-p-tolyl-4-aza-tricyclo[5.2.1.0^2,6]dec-8-ene-3,5-dione 
• 36745-13-8 C₄₀H₂₇NO₃ 

Relevant articles and documents

1,3-dipolar cycloaddition: Free catalytic synthesis and esophageal cancer activity of new 1,2,3-triazole-oxydianiline-maleimide hybrids

A new series of 1,2,3-triazole-oxydianiline-maleimide hybrids 12-15 was synthesized by using 1,3-dipolar cycloaddition reaction of N-Arylmaleimides 6-9 with 4,4'-oxybis(azidobenzene) 11 under an efficient and free catalytic reaction. All the newly synthesized hybrids were characterized by their 1H NMR, F-TIR, Mass spectral data and melting points. The cytotoxic activities (in vitro) of selected hybrids against esophageal cancer of human cell line (SKG) were evaluated by MTT assay. Among them, hybrid 13 exhibited a potent inhibition activity with the IC50 value of 1.61±0.01 μM against esophageal cancer cell (SKG). Cellular mechanism investigations in esophageal carcinoma cells (SKG) elucidated that hybrid 13 inhibited cell growths in vitro and arrested cell cycle at an environmental phase. These results revealed that hybrid 13 holds a promising anticancer agent with the enhancement of further clinical applications in drug discovery field.

The discovery, design and synthesis of potent agonists of adenylyl cyclase type 2 by virtual screening combining biological evaluation

Adenylate cyclases (ACs), play a critical role in the conversion of adenosine triphosphate (ATP) into the second messenger cyclic adenosine monophosphate (cAMP). Studies have indicated that adenylyl cyclase type 2 (AC2) is potential drug target for many diseases, however, up to now, there is no AC2-selective agonist reported. In this research, docking-based virtual screening with the combination of cell-based biological assays have been performed for discovering novel potent and selective AC2 agonists. Virtual screening disclosed a novel hit compound 8 as an AC2 agonist with EC50 value of 8.10 μM on recombinant human hAC2 + HEK293 cells. The SAR (structure activity relationship) based on the derivatives of compound 8 was further explored on recombinant AC2 cells and compound 73 was found to be the most active agonist with the EC50 of 90 nM, which is 160-fold more potent than the reported agonist Forskolin and could selectively activate AC2 to inhibit the expression of Interleukin-6. The discovery of a new class of AC2-selective agonists would provide a novel chemical probe to study the physiological function of AC2.

Regioselective hydroarylation and arylation of maleimides with indazoles: Via a Rh(iii)-catalyzed C-H activation

Switchable Rh(iii)-catalyzed highly regioselective hydroarylation and oxidative arylation of maleimides with 2-arylindazoles via C-H activation have been demonstrated. The reaction affords 3-(2-(2H-indazol-2-yl)phenyl)succinimide and 3-(2-(2H-indazol-2-yl)phenyl)maleimide derivatives in high yields with wide functional group tolerance. A mechanistic study was performed to depict C-H bond cleavage that might be involved in the turnover limiting step.