27567-82-4Relevant articles and documents
A New General Approach to Bicyclopropylidenes
Meijere, Armin de,Kozhushkov, Sergei I.,Spaeth, Thomas,Zefirov, Nikolai S.
, p. 502 - 505 (1993)
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Le Perchec,Conia
, p. 1587 (1970)
PROCESS OF MAKING CFTR MODULATORS
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, (2021/02/19)
The disclosure provides processes for synthesizing Compound I, and pharmaceutically acceptable salts thereof.
Synthesis of Spiro[2.2]pentanes and Spiro[2.3]hexanes Employing the Me3Al/CH2I2 Reagent
Ramazanov, Ilfir R.,Kadikova, Rita N.,Zosim, Tat'yana P.,Dzhemilev, Usein M.,de Meijere, Armin
, p. 7060 - 7067 (2017/12/28)
Substituted alkylidenecyclopropanes reacted with 5 equivalents each of Me3Al and CH2I2 at room temperature in hexane to give 1-mono- and 1,1-disubstituted spiro[2.2]pentanes in high yields. Surprisingly, the same reaction
