28447-17-8

Basic information

• Product Name: ETHYL 3-(3-PYRIDYL)ACRYLATE
• Synonyms: RARECHEM AL BI 1522;ETHYL 3-(3-PYRIDYL)ACRYLATE;AURORA KA-1039;3PYAAE;3-PYRIDINEACRYLIC ACID ETHYL ESTER;2-PROPENOIC ACID, 3-(3-PYRIDINYL)-, ETHYL ESTER;Zinc02577194;Ethyl 3-pyridineacrylate
• CAS NO: 28447-17-8
• Molecular Formula: C₁₀H₁₁NO₂
• Molecular Weight: 177.2
• Mol File: 28447-17-8.mol
• Article Data: 55

Chemical Properties

• Boiling Point: 285.2 °C at 760 mmHg
• Flash Point: 126.3 °C
• Appearance: /
• Density: 1.106 g/cm³
• Vapor Pressure: 0.00322mmHg at 25°C
• Refractive Index: 1.553
• Storage Temp.: 2-8°C
• Solubility: Dichloromethane, Ethyl Acetate
• CAS DataBase Reference: ETHYL 3-(3-PYRIDYL)ACRYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 3-(3-PYRIDYL)ACRYLATE(28447-17-8)
• EPA Substance Registry System: ETHYL 3-(3-PYRIDYL)ACRYLATE(28447-17-8)

Safety Data

• Hazardous Substances Data: 28447-17-8(Hazardous Substances Data)

Usage

General Description

ETHYL 3-(3-PYRIDYL)ACRYLATE is a chemical compound with the molecular formula C11H11NO2. It is formed by the esterification of 3-(3-pyridyl)acrylic acid with ethanol. ETHYL 3-(3-PYRIDYL)ACRYLATE is an ester with a pyridine ring attached to the acrylate group. It is commonly used in the synthesis of pharmaceuticals, agrochemicals, and organic materials due to its versatile reactivity and potential applications in drug design. It also finds use as a building block in the synthesis of various organic compounds and materials.ETHYL 3-(3-PYRIDYL)ACRYLATE has potential applications in the field of medicinal chemistry and organic synthesis due to its unique structure and reactivity.

InChI:InChI=1/C10H11NO2/c1-2-13-10(12)7-6-9-5-3-4-8-11-9/h3-8H,2H2,1H3/b7-6+

Upstream product

• 54495-51-1 (E)-3-(2-pyridyl)acrylic acid 
• 500-22-1 3-pyridinecarboxaldehyde 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 141-78-6 ethyl acetate 
• 105-36-2 ethyl bromoacetate 
• 462-08-8 pyridin-3-ylamine 
• 140-88-5 ethyl acrylate 
• 1126-74-5 3-(pyridin-3-yl)acrylic acid 
• 64-17-5 ethanol 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 228271-59-8 3-(3'-pyridinyl)-(Z)-propenoic acid methyl ester 
• 65946-56-7 1-ethoxy-1-(trimethylsiloxy)-2-(trimethylsilyl)ethene 
• 100-55-0 3-hydroxymethylpyridin 
• 372-31-6 ethyl 4,4,4-trifluoroacetoacetate 

Downstream Products

• 69963-46-8 3-(pyridin-3-yl)prop-2-en-1-ol 
• 19337-97-4 trans-3-(3-pyridyl)acrylic acid 
• 28447-15-6 trans-3-(3-pyridyl)acrolein 
• 210565-12-1 (R,S)-1-{3(R)-[N-(tert-butyloxycarbonyl)-3-piperidinyl]propyl}-2-[(4-chlorophenoxy)methyl]-4-({3(S)-[N-(tert-butyloxycarbonyl)-3-piperidinyl]propyl}oxy)benzimidazole 
• 193627-94-0 (R,R)-1-{3(R)-[N-(tert-butyloxycarbonyl)-3-piperidinyl]propyl}-2-[(4-chlorophenoxy)methyl]-4-({3(R)-[N-(tert-butyloxycarbonyl)-3-piperidinyl]propyl}oxy)benzimidazole 
• 193627-96-2 (S,S)-1-{3(S)-[N-(tert-butyloxycarbonyl)-3-piperidinyl]propyl}-2-[(4-chlorophenoxy)methyl]-4-({3(S)-[N-(tert-butyloxycarbonyl)-3-piperidinyl]propyl}oxy)benzimidazole 
• 210565-05-2 (S,R)-1-{3(S)-[N-(tert-butyloxycarbonyl)-3-piperidinyl]propyl}-2-[(4-chlorophenoxy)methyl]-4-({3(R)-[N-(tert-butyloxycarbonyl)-3-piperidinyl]propyl}oxy)benzimidazole 
• 210223-01-1 tert-butyl (3R)-3-(3-ethoxy-3-oxopropyl)piperidine-1-carboxylate 
• 210564-95-7 (R)-3-{3-[2-(4-Chloro-phenoxymethyl)-4-hydroxy-benzoimidazol-1-yl]-propyl}-piperidine-1-carboxylic acid tert-butyl ester 
• 210564-92-4 (S)-3-{3-[2-(4-Chloro-phenoxymethyl)-4-hydroxy-benzoimidazol-1-yl]-propyl}-piperidine-1-carboxylic acid tert-butyl ester 
• 193628-06-7 (R)-3-{3-[4-Benzyloxy-2-(4-chloro-phenoxymethyl)-benzoimidazol-1-yl]-propyl}-piperidine-1-carboxylic acid tert-butyl ester 
• 193628-07-8 (S)-3-{3-[4-Benzyloxy-2-(4-chloro-phenoxymethyl)-benzoimidazol-1-yl]-propyl}-piperidine-1-carboxylic acid tert-butyl ester 
• 87307-84-4 ethyl 3-<4-(2-hydroxy-3-methoxyphenyl)pyridin-3-yl>propanoate 
• 87307-88-8 ethyl 3-<4-<2-(ethoxymethoxy)-3-methoxyphenyl>pyridin-3-yl>propanoate 

Relevant articles and documents

Studies on pyrimidine derivatives. X. Coupling reaction of 5-halopyrimidines with olefinic compounds in the presence of palladium acetate and triphenylphosphine

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Photoinduced Regioselective Olefination of Arenes at Proximal and Distal Sites

The Fujiwara-Moritani reaction has had a profound contribution in the emergence of contemporary C-H activation protocols. Despite the applicability of the traditional approach in different fields, the associated reactivity and regioselectivity issues had

Structure?Activity Relationships of Cinnamate Ester Analogues as Potent Antiprotozoal Agents

Protozoal infections are still a global health problem, threatening the lives of millions of people around the world, mainly in impoverished tropical and sub-tropical regions. Thus, in view of the lack of efficient therapies and increasing resistances against existing drugs, this study describes the antiprotozoal potential of synthetic cinnamate ester analogues and their structure-activity relationships. In general, Leishmania donovani and Trypanosoma brucei were quite susceptible to the compounds in a structure-dependent manner. Detailed analysis revealed a key role of the substitution pattern on the aromatic ring and a marked effect of the side chain on the activity against these two parasites. The high antileishmanial potency and remarkable selectivity of the nitro-aromatic derivatives suggested them as promising candidates for further studies. On the other hand, the high in vitro potency of catechol-type compounds against T. brucei could not be extrapolated to an in vivo mouse model.

Copper-catalyzed Mizoroki-Heck coupling reaction using an efficient and magnetically reusable Fe3O4@SiO2@PrNCu catalyst

This study intends to design and prepare a new magnetic copper catalyst and its activity was assessed by carbon-carbon coupling reactions. For this purpose, 1-[3-(trimethoxysilyl) propyl] urea (TMSPU), hydrazine and CuI were used sequentially to modify Fe3O4@SiO2 core-shell magnetic nanoparticles to obtain an efficient magnetic transition metal catalyst. Various analytical techniques were used to characterize the catalyst to show that the achieved structure and its properties are well-suited for coupling reactions. Finally, Mizoroki-Heck and Ullmann coupling reactions were performed using Fe3O4@SiO2@PrNCu catalyst. The new catalyst offer simple synthetic procedure, convenient use for routine casework and low price. The Fe3O4@SiO2@PrNCu catalyst was easily separated by means of a permanent and ordinary magnet and the recovered catalyst was reused in six cycles without any significant loss of activity.