3055-95-6

Basic information

• Product Name: C12E5
• Synonyms: C12E5, Dodecyl pentaethylene glycol ether, Dodecylpentaglycol, Polyoxyethylene (5) lauryl ether;Detergentien Screening-Lδsung 16/Fluka-Kit-Nr. 66317, Pentaethyleneglycol monododecyl ether solution;2-[2-[2-[2-(2-Dodecyloxyethoxy)ethoxy]ethoxy]ethoxy]ethanol;Pentaethylene glycol monolauryl ether;2-[2-[2-[2-(2-dodecoxyethoxy)ethoxy]ethoxy]ethoxy]ethanol;2-[2-[2-[2-(2-lauryloxyethoxy)ethoxy]ethoxy]ethoxy]ethanol;PentaethyleneglycolMonododecylether, C12E5;Detergentien Screening-Lsung 16/Fluka-Kit-Nr. 66317
• CAS NO: 3055-95-6
• Molecular Formula: C₂₂H₄₆O₆
• Molecular Weight: 406.6
• EINECS: 221-281-8
• Product Categories: Ethylene Glycols & Monofunctional Ethylene Glycols;Monofunctional Ethylene Glycols
• Mol File: 3055-95-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: 14.5-15.0 °C
• Boiling Point: 486.6 ºC at 760 mmHg
• Flash Point: 23 °C
• Appearance: solid
• Density: 0.963 g/mL at 20 °C(lit.)
• Refractive Index: 1.446～1.452(35℃/D)
• Storage Temp.: 2-8°C
• Solubility: Do you have solubility information on this product that you woul
• PKA: 14.36±0.10(Predicted)
• Stability: Stable. Flammable. Incompatible with strong oxidizing agents.
• BRN: 1797921
• CAS DataBase Reference: C12E5(CAS DataBase Reference)
• NIST Chemistry Reference: C12E5(3055-95-6)
• EPA Substance Registry System: C12E5(3055-95-6)

Safety Data

• Hazard Codes: Xi
• Statements: 37/38-41
• Safety Statements: 26-36/39
• WGK Germany: 2
• RTECS: SB0333332
• F: 10-23
• Hazardous Substances Data: 3055-95-6(Hazardous Substances Data)

Usage

Chemical Properties

solid

Definition

ChEBI: A hydroxypolyether that is pentaethylene glycol in which one of the terminal hydrogens is replaced by a dodecyl group.

InChI:InChI=1/C24H50O.C2H6O2.5C2H4/c1-3-5-7-9-11-13-15-17-19-21-23-25-24-22-20-18-16-14-12-10-8-6-4-2;3-1-2-4;5*1-2/h3-24H2,1-2H3;3-4H,1-2H2;5*1-2H2

Synthetic route

oxirane (75-21-8) + 1-dodecyl alcohol (112-53-8) → pentaethylene glycol mono-n-dodecyl ether (3055-95-6)

Conditions	Yield
With K10 clay at 50℃;	94%

tetraethylene glycol monododecyl ether (5274-68-0) + 2-chloro-ethanol (107-07-3) → pentaethylene glycol mono-n-dodecyl ether (3055-95-6)

Conditions	Yield
With sodium

1-dodecyl alcohol (112-53-8) → pentaethylene glycol mono-n-dodecyl ether (3055-95-6)

Conditions	Yield
Multi-step reaction with 5 steps 1: boron fluorid-acetic acid adduct 2: boron fluorid-acetic acid adduct 3: boron fluorid-acetic acid adduct 4: boron fluorid-acetic acid adduct 5: sodium View Scheme

ethylene glycol mono-n-dodecyl ether (4536-30-5) → pentaethylene glycol mono-n-dodecyl ether (3055-95-6)

Conditions	Yield
Multi-step reaction with 4 steps 1: boron fluorid-acetic acid adduct 2: boron fluorid-acetic acid adduct 3: boron fluorid-acetic acid adduct 4: sodium View Scheme

diethylene glycol monododecyl ether (3055-93-4) → pentaethylene glycol mono-n-dodecyl ether (3055-95-6)

Conditions	Yield
Multi-step reaction with 3 steps 1: boron fluorid-acetic acid adduct 2: boron fluorid-acetic acid adduct 3: sodium View Scheme

2-[2-(2-Dodecyloxy-ethoxy)-ethoxy]-ethanol (3055-94-5) → pentaethylene glycol mono-n-dodecyl ether (3055-95-6)

Conditions	Yield
Multi-step reaction with 2 steps 1: boron fluorid-acetic acid adduct 2: sodium View Scheme

pentaethylene glycol mono-n-dodecyl ether (3055-95-6) + bromoacetic acid (79-08-3) → C12E5OCH2COOH (20260-64-4)

Conditions	Yield
Stage #1: pentaethylene glycol mono-n-dodecyl ether With sodium hydride In tetrahydrofuran at 20℃; for 0.5h; Stage #2: bromoacetic acid In tetrahydrofuran at 60℃; for 12.5h;	94%
With sodium hydride In tetrahydrofuran at 60℃; for 12h;	90%

pentaethylene glycol mono-n-dodecyl ether (3055-95-6) + (2,3-Dioxo-2,3-dihydro-1H-indol-1-yl)acetic acid (60705-96-6) → C32H51NO9

Conditions	Yield
With sulfuric acid In toluene at 150℃; for 35h; Molecular sieve;	88.7%

pentaethylene glycol mono-n-dodecyl ether (3055-95-6) → dodecyltetraoxyethyleneoxyacetaldehyde

Conditions	Yield
With pyridinium trifluroacetate; dimethyl sulfoxide; dicyclohexyl-carbodiimide In toluene at 20℃; for 48h; Oxidation;	40%

pentaethylene glycol mono-n-dodecyl ether (3055-95-6) + sodium monochloroacetic acid (3926-62-3) → C12E5OCH2COOH (20260-64-4)

Conditions	Yield
With sodium In xylene at 110 - 130℃; for 16h;	25%

pentaethylene glycol mono-n-dodecyl ether (3055-95-6) + N-acetyl-L-tryptophanamide → 2-(2-{2-[2-(2-Dodecyloxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethanol; compound with (S)-2-acetylamino-3-(1H-indol-2-yl)-propionamide

Conditions	Yield
In water at 20℃;

pentaethylene glycol mono-n-dodecyl ether (3055-95-6) → C33H64O10N2

Conditions	Yield
Multi-step reaction with 2 steps 1: 90 percent / NaH / tetrahydrofuran / 12 h / 60 °C 2: 70 percent / 1-hydroxybenzotriazole; EDC / dimethylformamide / 12 h / 20 °C View Scheme

2-bromoethylphosphoric acid dichloride (4167-02-6) + pentaethylene glycol mono-n-dodecyl ether (3055-95-6) → 3,6,9,12,15-Pentaoxaheptacosyl 2-bromoethyl phosphate (81051-22-1)

Conditions	Yield
In tetrachloromethane; water; toluene

pentaethylene glycol mono-n-dodecyl ether (3055-95-6) → (2-{2-[2-(2-Dodecyloxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-acetic acid (21127-45-7)

Conditions	Yield
With Jones reagent In acetone at 20℃;

pentaethylene glycol mono-n-dodecyl ether (3055-95-6) + phenyl isocyanate (103-71-9) → C29H51NO7

Conditions	Yield
In methanol; acetonitrile at 70℃; for 1h;

Upstream product

• 5274-68-0 tetraethylene glycol monododecyl ether 
• 107-07-3 2-chloro-ethanol 
• 75-21-8 oxirane 
• 112-53-8 1-dodecyl alcohol 
• 3055-94-5 2-[2-(2-Dodecyloxy-ethoxy)-ethoxy]-ethanol 
• 3055-93-4 diethylene glycol monododecyl ether 
• 4536-30-5 ethylene glycol mono-n-dodecyl ether 

Downstream Products

• 21127-45-7 (2-{2-[2-(2-Dodecyloxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-acetic acid 
• 20260-64-4 C12E5OCH2COOH 

Relevant articles and documents

Nonionic Isatin Surfactants: Synthesis, Quantum Chemical Calculations, ADMET and Their Antimicrobial Activities

The most challenge task in the building up of surface-active molecules is maximizing their surface activity with good biological activity. A nonionic surfactant (N-isatin-EOm-Cn where m is 5, 7 and 9 ethylene glycol units and n is 8, 10 and 12) is achieved by first reacting isatin with chloroacetic acid and then with different types of ethoxylated (C8–C12) fatty alcohols that possess 5, 7 and 9 ethylene oxide units. The prepared surfactants were characterized by FTIR and 1H NMR to confirm the structure. The surface activity, biodegradability, antimicrobial, and antifungal activity of the surfactants were evaluated. In addition, quantum chemical calculations and computations of oral bioavailability were performed. The obtained data show that all the synthesized compounds had good surface activity, biodegradability and biological activity.