3055-97-8

Basic information

• Product Name: Dodecylheptaglycol
• Synonyms: 3,6,9,12,15,18,21-Heptaoxatritriacontan-1-ol;C12E7;DODECYLHEPTAGLYCOL;HEPTAOXYETHYLENE MONO-N-DODECYL ETHER;HEPTAETHYLENE GLYCOL MONO-N-DODECYL ETHER;HEPTAETHYLENE GLYCOL MONODODECYL ETHER;HEPTAETHYLENE GLYCOL DODECYL ETHER;POLYOXYETHYLENE 7 LAURYL ETHER
• CAS NO: 3055-97-8
• Molecular Formula: C₂₆H₅₄O₈
• Molecular Weight: 494.7
• EINECS: 221-283-9
• Product Categories: Ethylene Glycols & Monofunctional Ethylene Glycols;Monofunctional Ethylene Glycols
• Mol File: 3055-97-8.mol
• Article Data: 5

Chemical Properties

• Melting Point: 27-29 °C
• Boiling Point: 553.945 °C at 760 mmHg
• Flash Point: 27 °C
• Appearance: /
• Density: 0.99 g/cm³
• Vapor Pressure: 1.4E-14mmHg at 25°C
• Refractive Index: 1.457
• Storage Temp.: 2-8°C
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• PKA: 14.36±0.10(Predicted)
• CAS DataBase Reference: Dodecylheptaglycol(CAS DataBase Reference)
• NIST Chemistry Reference: Dodecylheptaglycol(3055-97-8)
• EPA Substance Registry System: Dodecylheptaglycol(3055-97-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 2
• F: 3
• Hazardous Substances Data: 3055-97-8(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 3055-97-8 differently. You can refer to the following data:
1. Heptaethylene Glycol Monododecyl Ether (laureth-7) is a wetting agent also used as an emulsifier, surfactant, detergent, and solubilizer for active substances.
2. Heptaethylene glycol monododecyl ether is a non-ionic detergent compound.

InChI:InChI=1/C26H54O8/c1-2-3-4-5-6-7-8-9-10-11-13-28-15-17-30-19-21-32-23-25-34-26-24-33-22-20-31-18-16-29-14-12-27/h27H,2-26H2,1H3

Synthetic route

oxirane (75-21-8) + 1-dodecyl alcohol (112-53-8) → heptaethylene glycol monododecyl ether (3055-97-8)

Conditions	Yield
With K10 clay at 50℃;	94%
With potassium hydroxide at 140 - 170℃;

tetraethylene glycol monododecyl ether (5274-68-0) + C6H12O6S → heptaethylene glycol monododecyl ether (3055-97-8)

Conditions	Yield
Stage #1: tetraethylene glycol monododecyl ether With sodium hydride In tetrahydrofuran; mineral oil for 0.5h; Inert atmosphere; Stage #2: C6H12O6S In tetrahydrofuran; mineral oil pH=2; Inert atmosphere; Stage #3: With sulfuric acid In tetrahydrofuran; water; mineral oil at 80℃; for 2h; Inert atmosphere;	88%

1-(2-{2-[2-(2-chloro-ethoxy)-ethoxy]-ethoxy}-ethoxy)-dodecane (81782-65-2) + 2,2'-[1,2-ethanediylbis(oxy)]bisethanol (112-27-6) → heptaethylene glycol monododecyl ether (3055-97-8)

Conditions	Yield
With sodium

2,2'-[1,2-ethanediylbis(oxy)]bisethanol (112-27-6) → heptaethylene glycol monododecyl ether (3055-97-8)

Conditions	Yield
Multi-step reaction with 2 steps 1.1: triethylamine; dmap; thionyl chloride / dichloromethane / 0 - 25 °C 2.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / Inert atmosphere 2.2: pH 2 / Inert atmosphere 2.3: 2 h / 80 °C / Inert atmosphere View Scheme

Tetraethylene glycol (112-60-7) → heptaethylene glycol monododecyl ether (3055-97-8)

Conditions

Yield

Multi-step reaction with 3 steps 1.1: triethylamine; dmap; thionyl chloride / dichloromethane / 0 - 25 °C 2.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / Inert atmosphere 2.2: pH 2 / Inert atmosphere 2.3: 2 h / 80 °C / Inert atmosphere 3.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / Inert atmosphere 3.2: pH 2 / Inert atmosphere 3.3: 2 h / 80 °C / Inert atmosphere View Scheme

1,3,6,9,12-pentaoxa-2-thiacyclotetradecane 2,2-dioxide → heptaethylene glycol monododecyl ether (3055-97-8)

Conditions	Yield
Multi-step reaction with 2 steps 1.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / Inert atmosphere 1.2: pH 2 / Inert atmosphere 1.3: 2 h / 80 °C / Inert atmosphere 2.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / Inert atmosphere 2.2: pH 2 / Inert atmosphere 2.3: 2 h / 80 °C / Inert atmosphere View Scheme

hexan-1-ol (111-27-3) → heptaethylene glycol monododecyl ether (3055-97-8)

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium hydroxide; zinc(II) oxide / 3 h / 210 °C / Inert atmosphere 2: potassium hydroxide / 1 h / 110 - 140 °C / 1500.15 Torr / Inert atmosphere View Scheme

oxirane (75-21-8) + 2-(n-butyl)octanol (3913-02-8) → heptaethylene glycol monododecyl ether (3055-97-8)

Conditions	Yield
With potassium hydroxide at 110 - 140℃; under 1500.15 Torr; for 1h; Inert atmosphere;

heptaethylene glycol monododecyl ether (3055-97-8) + methyl iodide (74-88-4) → 1-(2-{2-[2-(2-{2-[2-(2-Methoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-dodecane (63425-08-1)

Conditions	Yield
Stage #1: heptaethylene glycol monododecyl ether With sodium hydride In tetrahydrofuran; mineral oil for 0.5h; Inert atmosphere; Stage #2: methyl iodide In tetrahydrofuran; mineral oil Inert atmosphere;	94%

(2,3-Dioxo-2,3-dihydro-1H-indol-1-yl)acetic acid (60705-96-6) + heptaethylene glycol monododecyl ether (3055-97-8) → C36H59NO11

Conditions	Yield
With sulfuric acid In toluene at 150℃; for 35h; Molecular sieve;	88.11%

heptaethylene glycol monododecyl ether (3055-97-8) + C6H12O6S → C32H65O14S(1-)*Na(1+)

Conditions	Yield
Stage #1: heptaethylene glycol monododecyl ether With sodium hydride In tetrahydrofuran; mineral oil for 0.5h; Inert atmosphere; Stage #2: C6H12O6S In tetrahydrofuran; mineral oil Inert atmosphere;	82%

heptaethylene glycol monododecyl ether (3055-97-8) + p-toluenesulfonyl chloride (98-59-9) → C33H60O10S

Conditions	Yield
Stage #1: heptaethylene glycol monododecyl ether With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.166667h; Inert atmosphere; Stage #2: p-toluenesulfonyl chloride In tetrahydrofuran; mineral oil at 0 - 20℃; for 14h; Inert atmosphere;	72%

heptaethylene glycol monododecyl ether (3055-97-8) + 1,3,6,9,12-pentaoxa-2-thiacyclotetradecane 2,2-dioxide → C34H69O15S(1-)*Na(1+)

Conditions	Yield
Stage #1: heptaethylene glycol monododecyl ether With sodium hydride In tetrahydrofuran; mineral oil for 0.5h; Inert atmosphere; Stage #2: 1,3,6,9,12-pentaoxa-2-thiacyclotetradecane 2,2-dioxide In tetrahydrofuran; mineral oil Inert atmosphere;	59%

heptaethylene glycol monododecyl ether (3055-97-8) + C6H12O6S → decaethylene glycol monodecyl ether (6540-99-4)

Conditions	Yield
Stage #1: heptaethylene glycol monododecyl ether With sodium hydride In tetrahydrofuran; mineral oil for 0.5h; Inert atmosphere; Stage #2: C6H12O6S In tetrahydrofuran; mineral oil pH=2; Inert atmosphere; Stage #3: With sulfuric acid In tetrahydrofuran; water; mineral oil at 80℃; for 2h; Inert atmosphere;	56%

heptaethylene glycol monododecyl ether (3055-97-8) + 1,3,6,9,12-pentaoxa-2-thiacyclotetradecane 2,2-dioxide → 2-(2-{2-[2-(2-{2-[2-(2-{2-[2-(2-dodecyloxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethanol (25763-63-7)

Conditions	Yield
Stage #1: heptaethylene glycol monododecyl ether With sodium hydride In tetrahydrofuran; mineral oil for 0.5h; Inert atmosphere; Stage #2: 1,3,6,9,12-pentaoxa-2-thiacyclotetradecane 2,2-dioxide In tetrahydrofuran; mineral oil pH=2; Inert atmosphere; Stage #3: With sulfuric acid In tetrahydrofuran; water; mineral oil at 80℃; for 2h; Inert atmosphere;	48%

heptaethylene glycol monododecyl ether (3055-97-8) + Methacryloyl chloride (920-46-7) → C30H58O9

Conditions	Yield
With triethylamine In dichloromethane at 0℃;

heptaethylene glycol monododecyl ether (3055-97-8) → C26H52O9

Conditions	Yield
With oxygen In water at 80℃; under 6000.6 Torr; for 20h; pH=11; Reagent/catalyst; Autoclave;

heptaethylene glycol monododecyl ether (3055-97-8) → C30H55FN2O9

Conditions	Yield
Multi-step reaction with 3 steps 1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 0 °C / Inert atmosphere 1.2: 14 h / 0 - 20 °C / Inert atmosphere 2.1: sodium bromide / acetone / 72 h / 65 °C / Inert atmosphere 3.1: potassium carbonate / N,N-dimethyl-formamide / 0.25 h / 20 °C / Inert atmosphere 3.2: 2 h / 20 - 80 °C / Inert atmosphere View Scheme

heptaethylene glycol monododecyl ether (3055-97-8) → C26H53BrO7

Conditions	Yield
Multi-step reaction with 2 steps 1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 0 °C / Inert atmosphere 1.2: 14 h / 0 - 20 °C / Inert atmosphere 2.1: sodium bromide / acetone / 72 h / 65 °C / Inert atmosphere View Scheme

heptaethylene glycol monododecyl ether (3055-97-8) + C12H14O8 → C38H66O15

Conditions	Yield
at 175℃; Concentration; Temperature; Inert atmosphere;

heptaethylene glycol monododecyl ether (3055-97-8) → C26H51O9(1-)*Na(1+)

Conditions	Yield
With dihydrogen peroxide; sodium hydroxide In water at 80℃; for 10h; Reagent/catalyst;

heptaethylene glycol monododecyl ether (3055-97-8) + C6H12O6S → C33H68O11

Conditions	Yield
Multi-step reaction with 2 steps 1.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / Inert atmosphere 1.2: pH 2 / Inert atmosphere 1.3: 2 h / 80 °C / Inert atmosphere 2.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / Inert atmosphere 2.2: Inert atmosphere View Scheme

heptaethylene glycol monododecyl ether (3055-97-8) + 1,3,6,9,12-pentaoxa-2-thiacyclotetradecane 2,2-dioxide → C35H72O12

Conditions	Yield
Multi-step reaction with 2 steps 1.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / Inert atmosphere 1.2: pH 2 / Inert atmosphere 1.3: 2 h / 80 °C / Inert atmosphere 2.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / Inert atmosphere 2.2: Inert atmosphere View Scheme

heptaethylene glycol monododecyl ether (3055-97-8) + phenyl isocyanate (103-71-9) → C33H59NO9

Conditions	Yield
In methanol; acetonitrile at 70℃; for 1h;

heptaethylene glycol monododecyl ether (3055-97-8) → C26H55O11P + C26H55O10P

Conditions	Yield
Stage #1: heptaethylene glycol monododecyl ether With phosphorus pentoxide at 80℃; for 5h; Inert atmosphere; Stage #2: With water for 1h; Temperature;

heptaethylene glycol monododecyl ether (3055-97-8) + mercaptopentyltriethoxysilane → C59H122O17SSi

Conditions	Yield
With titanium(IV)isopropoxide at 90 - 120℃; for 5h;

Upstream product

• 75-21-8 oxirane 
• 112-53-8 1-dodecyl alcohol 
• 112-27-6 2,2'-[1,2-ethanediylbis(oxy)]bisethanol 
• 112-60-7 Tetraethylene glycol 
• 5274-68-0 tetraethylene glycol monododecyl ether 
• 111-27-3 hexan-1-ol 
• 3913-02-8 2-(n-butyl)octanol 
• 81782-65-2 1-(2-{2-[2-(2-chloro-ethoxy)-ethoxy]-ethoxy}-ethoxy)-dodecane 

Downstream Products

• 6540-99-4 decaethylene glycol monodecyl ether 

Relevant articles and documents

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The most challenge task in the building up of surface-active molecules is maximizing their surface activity with good biological activity. A nonionic surfactant (N-isatin-EOm-Cn where m is 5, 7 and 9 ethylene glycol units and n is 8, 10 and 12) is achieved by first reacting isatin with chloroacetic acid and then with different types of ethoxylated (C8–C12) fatty alcohols that possess 5, 7 and 9 ethylene oxide units. The prepared surfactants were characterized by FTIR and 1H NMR to confirm the structure. The surface activity, biodegradability, antimicrobial, and antifungal activity of the surfactants were evaluated. In addition, quantum chemical calculations and computations of oral bioavailability were performed. The obtained data show that all the synthesized compounds had good surface activity, biodegradability and biological activity.

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