3340-93-0

Basic information

• Product Name: 12-methylbenz(a)acridine
• Synonyms: 12-methylbenz(a)acridine
• CAS NO: 3340-93-0
• Molecular Formula: C₁₈H₁₃N
• Molecular Weight: 243.32
• Mol File: 3340-93-0.mol
• Article Data: 3

Chemical Properties

• Melting Point: 144.5°C
• Boiling Point: 376.18°C (rough estimate)
• Flash Point: 205.5°C
• Appearance: /
• Density: 0.8933 (rough estimate)
• Vapor Pressure: 3.88E-08mmHg at 25°C
• Refractive Index: 1.4500 (estimate)
• CAS DataBase Reference: 12-methylbenz(a)acridine(CAS DataBase Reference)
• NIST Chemistry Reference: 12-methylbenz(a)acridine(3340-93-0)
• EPA Substance Registry System: 12-methylbenz(a)acridine(3340-93-0)

Safety Data

• Hazardous Substances Data: 3340-93-0(Hazardous Substances Data)

Usage

Chemical classification

Polycyclic aromatic hydrocarbon compound

Physical state

Yellow solid

Molecular weight

263.33 g/mol

Known properties

Potent mutagenic and carcinogenic

Usage

Laboratory research (inducing DNA damage, studying mutagenesis and carcinogenesis mechanisms), organic dyes and pigments component

Health risks

Increased risk of developing cancer (inhalation or skin contact)

Concerns

Occupational and environmental health and safety

InChI:InChI=1/C18H13N/c1-12-14-7-4-5-9-16(14)19-17-11-10-13-6-2-3-8-15(13)18(12)17/h2-11H,1H3

Upstream product

• 135-88-6 N-Phenyl-2-naphthylamine 
• 108-24-7 acetic anhydride 
• 64-19-7 acetic acid 
• 580-13-2 2-bromonaphthalene 
• 551-93-9 2-aminoacetophenone 
• 574-19-6 1-(2-hydroxy-1-naphthyl)ethan-1-one 
• 62-53-3 aniline 
• 32316-92-0 naphthalene-2-boronic acid 

Downstream Products

• 1609956-64-0 (benzo[a]acridin-12-yl)methyl 4-nitrobenzoate 
• 1609956-63-9 (benzo[a]acridin-12-yl)methyl 4-vinylbenzoate 
• 1609956-62-8 (benzo[a]acridin-12-yl)methyl 4-methoxybenzoate 
• 1609956-61-7 (benzo[a]acridin-12-yl)methyl 4-methylbenzoate 
• 1609956-60-6 (benzo[a]acridin-12-yl)methyl benzoate 
• 1609956-59-3 (benzo[a]acridin-12-yl)methyl 2-phenylacetate 
• 34331-96-9 12-(bromomethyl)benzo[a]acridine 
• 1609956-68-4 (benzo[a]acridin-12-yl)methyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate 
• 632-50-8 1,1,2,2-tetraphenylethane 
• 101-81-5 Diphenylmethane 
• 83876-50-0 cis-5,6-dihydro-5,6-dihydroxy-12-methylbenzacridine 
• 13471-30-2 7H-benzo[a]acridin-12-one 
• 104134-85-2 N-benz[a]acridin-12-ylmethylene-N',N'-dimethyl-p-phenylenediamine-N-oxide 
• 63019-59-0 4-(2-benzo[a]acridin-12-yl-vinyl)-N,N-dimethyl-aniline 

Relevant articles and documents

Tert-Butyl Bromide-Promoted Intramolecular Cyclization of 2-Arylamino Phenyl Ketones and Its Combination with Cu-Catalyzed C-N Coupling: Synthesis of Acridines at Room Temperature

Herein, a facile intramolecular cyclization of 2-arylamino phenyl ketones is established to supersede the traditional high-temperature, strongly acidic conditions and achieve 9-substituted acridines, by virtue of the combination of 2,2,2-trifluoroethanol and tert-butyl bromide. This protocol can be merged well with the preceding Cu-catalyzed intermolecular Chan-Evans-Lam cross-coupling reactions, therefore enabling pot-economic modular synthesis of 9-substituted acridines from readily available 2-amino phenyl ketones and aryl boronic acids at room temperature.

Rapid synthesis of acridines using microwave

Microwave irradiation for several minutes caused reaction of diarylamines with carboxylic acids in the presence of zinc chloride to give 9-substituted acridines in good yield.