3376-33-8

Basic information

• Product Name: (1Z)-1-phenylethanone O-methyloxime
• CAS NO: 3376-33-8
• Molecular Formula: C₉H₁₁NO
• Molecular Weight: 149.1897
• Mol File: 3376-33-8.mol
• Article Data: 22

Chemical Properties

• Boiling Point: 206.4°C at 760 mmHg
• Flash Point: 67.4°C
• Density: 0.94g/cm³
• Vapor Pressure: 0.342mmHg at 25°C
• Refractive Index: 1.487
• CAS DataBase Reference: (1Z)-1-phenylethanone O-methyloxime(CAS DataBase Reference)
• NIST Chemistry Reference: (1Z)-1-phenylethanone O-methyloxime(3376-33-8)
• EPA Substance Registry System: (1Z)-1-phenylethanone O-methyloxime(3376-33-8)

Safety Data

• Hazardous Substances Data: 3376-33-8(Hazardous Substances Data)

Usage

General Description

(1Z)-1-phenylethanone O-methyloxime is a chemical compound with the molecular formula C9H11NO. It is a methoxy derivative of acetophenone, and is commonly used in organic synthesis and as a reagent in chemical reactions. (1Z)-1-phenylethanone O-methyloxime is a crystalline solid with a melting point of 60-63°C and a boiling point of 110-112°C. It is known for its ability to undergo various chemical transformations, making it a versatile compound for use in organic chemistry. Furthermore, (1Z)-1-phenylethanone O-methyloxime is also used in the pharmaceutical industry for the synthesis of various drugs and pharmaceutical intermediates.

Upstream product

• 98-86-2 acetophenone 
• 74-88-4 methyl iodide 
• 77-78-1 dimethyl sulfate 
• 613-91-2 acetophenone oxime 
• 616-38-6 carbonic acid dimethyl ester 
• 593-56-6 N-methoxylamine hydrochloride 
• 124-41-4 sodium methylate 

Downstream Products

• 1519065-44-1 benzyl (E)-2-(1-(methoxyimino)ethyl)phenylcarbamate 
• 54758-74-6 1-(2-hydroxyphenyl)ethan-1-one O-methyl oxime 
• 89985-53-5 1-(2-hydroxyphenyl)ethylamine 
• 1446326-02-8 C₁₇H₁₄N₂O₃ 
• 883021-29-2 2-(4-fluorophenyl)-3-methyleneisoindolin-1-one 
• 1282051-37-9 2-(4-bromophenyl)-3-methyleneisoindolin-1-one 
• 218787-68-9 2,3-dihydro-3-methylene-2-(4'-methoxyphenyl)-1H-isoindolone 
• 131119-95-4 2,3-dihydro-3-methylene-2-(4'-methylphenyl)-1H-isoindolone 
• 1401733-54-7 (2-(1-(methoxyimino)ethyl)phenyl)(phenyl)methanone 
• 1393678-64-2 ethyl 2-(diethylphosphono)-2-(2-((E)-1-methoxyiminoethyl)phenyl)acetate 
• 1393678-77-7 dimethyl 2-(2-acetylphenyl)malonate 
• 1393678-67-5 methyl 2-(2-((E)-1-methoxyiminoethyl)phenyl)-3-morpholino-3-oxopropanoate 
• 1393679-01-0 C₁₄H₁₃⁽²⁾H₄NO₅ 

Relevant articles and documents

Access to Branched Allylarenes via Rhodium(III)-Catalyzed C-H Allylation of (Hetero)arenes with 2-Methylidenetrimethylene Carbonate

A rhodium(III)-catalyzed C-H allylation of (hetero)arenes by using 2-methylidenetrimethylene carbonate as an efficient allylic source has been developed for the first time. Five different directing groups including oxime, N-nitroso, purine, pyridine, and pyrimidine were compatible, delivering various branched allylarenes bearing an allylic hydroxyl group in moderate to excellent yields.

Regio-Divergent C—H Alkynylation with Janus Directing Strategy via Ir(III) Catalysis

Directing strategy has been extensively exploited to maintain activity and selectivity for the rapid access to functionalized molecules and pharmaceutical targets. However, ‘one-to-one’ activation model was usually achieved through traditional directing strategy. Herein, we achieved ‘one-to-two’ activation model by slight modification of simple and practical ketoxime and amide functionality. With judicious choice of directing groups, Csp3—H and Csp2—H bond alkynylation reaction, and more significantly, dehydrogenative Csp3—H alkynylation, were realized, enabling the regio-divergent late-stage modifications of pharmaceuticals.

Rhodium(III)-Catalyzed Oxidative Annulation of Ketoximes with Sulfonamide: A Direct Approach to Indazoles

A rhodium(III)-catalyzed intermolecular C-H amination of ketoxime and iodobenzene diacetate-enabled N-N bond formation in the synthesis of indazoles has been developed. A variety of functional groups were well tolerated, providing the corresponding produc