364050-21-5 Usage
Molecular Weight
238.24 g/mol
Structure
A diketone derivative with a backbone of ethanedione and two attached heterocyclic rings 6-methyl-2-pyridinyl and 6-quinoxalinyl.
Functional Groups
Two carbonyl (C=O) groups
Aromatic rings in the heterocyclic structures
Appearance
Likely a solid or crystalline compound, though specific appearance is not provided.
Potential Applications
Organic synthesis
Medicinal chemistry
Use as a Building Block
Can be used in the synthesis of various pharmaceuticals and biologically active compounds.
Biological Activity
The presence of heterocyclic rings may impart specific biological activities, making it of interest for further research and development in the field of pharmaceuticals and medicinal chemistry.
Stability
Information on stability is not provided, but as a diketone derivative, it may be sensitive to certain conditions such as high temperatures or strong bases.
Solubility
Information on solubility is not provided, but it may be soluble in organic solvents like ethanol, methanol, or acetone due to its nonpolar nature.
Reactivity
As a diketone derivative, it may undergo various reactions such as condensation, reduction, or substitution reactions. The presence of heterocyclic rings may also allow for additional reactions specific to those functional groups.
Check Digit Verification of cas no
The CAS Registry Mumber 364050-21-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,6,4,0,5 and 0 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 364050-21:
(8*3)+(7*6)+(6*4)+(5*0)+(4*5)+(3*0)+(2*2)+(1*1)=115
115 % 10 = 5
So 364050-21-5 is a valid CAS Registry Number.
364050-21-5Relevant articles and documents
Synthesis and biological evaluation of benzenesulfonamide-substituted 4-(6-alkylpyridin-2-yl)-5-(quinoxalin-6-yl)imidazoles as transforming growth factor-β type 1 receptor kinase inhibitors
Kim, Dae-Kee,Jung, Sun Hee,Lee, Ho Soon,Dewang, Purushottam M.
experimental part, p. 568 - 576 (2009/09/27)
A series of benzenesulfonamide-substituted 4-(6-alkylpyridin-2-yl)-5-(quinoxalin-6-yl)imidazoles (15a-l) have been synthesized and evaluated for their ALK5 inhibitory activity in cell-based luciferase reporter assays. Among them, 4-[5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1H-imidazol-2-ylmethyl]b enzenesulfonamide (15b) and 4-[5-(6-ethylpyridin-2-yl)-4-(quinoxalin-6-yl)-1H-imidazol-2-ylmethyl]be nzenesulfonamide (15c) showed more than 90% inhibition at 0.5 μM in a luciferase reporter assay using HaCaT cells transiently transfected with p3TP-luc reporter construct, but inhibited p38α MAP kinase activity only 11 and 8% at a concentration of 10 μM, respectively.
2-Pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors
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Page/Page column 9, (2008/06/13)
Compounds of the formula: wherein R1, R2, R3, A1 and A2 are as defined herein, which are used advantageously in inhibiting the TGF-β and/or activin signaling pathway in mammals.