3760-95-0

Basic information

• Product Name: (R)-(+)-1,2-Epoxybutane
• Synonyms: (2R)-(+)-1,2-Epoxybutane, (2R)-(+)-2-Ethyloxirane;(2R)-(+)-3-Methyl-1,2-propenoxide 98+%;(R)-()-1,2-Butylene oxide;Oxirane, 2-ethyl-,(2R)-;(R)-(+)-1,2-Epoxybutane 98%;(R)-(+)-1,2-EPOXYBUTANE;(R)-1,2-EPOXYBUTANE;2R-ETHYLOXIRANE
• CAS NO: 3760-95-0
• Molecular Formula: C₄H₈O
• Molecular Weight: 72.11
• Product Categories: Chiral Compounds;Epoxides;API intermediates
• Mol File: 3760-95-0.mol
• Article Data: 23

Chemical Properties

• Boiling Point: 63 °C(lit.)
• Flash Point: 10 °F
• Appearance: /
• Density: 0.837 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.386(lit.)
• CAS DataBase Reference: (R)-(+)-1,2-Epoxybutane(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(+)-1,2-Epoxybutane(3760-95-0)
• EPA Substance Registry System: (R)-(+)-1,2-Epoxybutane(3760-95-0)

Safety Data

• Hazard Codes: F,T
• Statements: 20/21/22-34-40
• Safety Statements: 16-26-27-36/37/39-45
• RIDADR: UN 3022 3/PG 2
• WGK Germany: 3
• HazardClass: 3
• PackingGroup: II
• Hazardous Substances Data: 3760-95-0(Hazardous Substances Data)

Usage

Chemical Properties

Colorless liquid

Upstream product

• 106-88-7 ethyloxirane 
• 70379-72-5 (R)-2-acetoxy-1-bromobutane 
• 40348-66-1 (R)-1,2-butanediol 
• 93246-17-4 ((R)-2-Hydroxy-butyl)-trimethyl-ammonium; hydroxide 
• 136656-75-2 (R)-(-)-1-(benzenesulfanyl)-2-butanol 
• 72952-76-2 S-(-)-1-bromo-2-acetoxy-butane 
• 145021-04-1 (R)-1-tert-Butylsulfanyl-butan-2-ol 
• 56536-49-3 (2S)-2-chlorobutan-1-ol 
• 51-79-6 urethane 
• 917-61-3 sodium isocyanate 
• 124-38-9 carbon dioxide 

Downstream Products

• 89479-94-7 (R)(-)-1-N-benzylaminobutan-2-ol 
• 93246-19-6 (R)-2-(3,5-Bisphenyl)-2-(2-hydroxybutyl)-1,3-dithiane 
• 13552-21-1 (R)(-)-1-aminobutan-2-ol 
• 198561-27-2 (R)-3-hydroxypentanenitrile 
• 4221-99-2 (S)-2-butanol 
• 71-36-3 butan-1-ol 
• 1092363-41-1 (R)-N-(2-hydroxybutyl)-4-methylbenzenesulfonamide 
• 1087160-39-1 C₁₅H₁₃BrF₅N₃O₂ 
• 105836-17-7 (R)-1-phenyl-3-pentanol 
• 1429383-27-6 (R)-1-((3,4-dimethoxybenzyl)oxy)butan-2-ol 

Relevant articles and documents

Aromatic Donor-Acceptor Interaction-Based Co(III)-salen Self-Assemblies and Their Applications in Asymmetric Ring Opening of Epoxides

Aromatic donor-acceptor interaction as the driving force to assemble cooperative catalysts is described. Pyrene/naphthalenediimide functionalized Co(III)-salen complexes self-assembled into bimetallic catalysts through aromatic donor-acceptor interactions and showed high catalytic activity and selectivity in the asymmetric ring opening of various epoxides. Control experiments, nuclear magnetic resonance (NMR) spectroscopy titrations, mass spectrometry measurement, and X-ray crystal structure analysis confirmed that the catalysts assembled based on the aromatic donor-acceptor interaction, which can be a valuable noncovalent interaction in supramolecular catalyst development.

OXYSTEROLS AND METHODS OF USE THEREOF

Compounds are provided according to Formula (I): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein R2, R3, R4, R5, and and R6 are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.

Azidolysis of epoxides catalysed by the halohydrin dehalogenase from Arthrobacter sp. AD2 and a mutant with enhanced enantioselectivity: an (S)-selective HHDH

Halohydrin dehalogenase from Arthrobacter sp. AD2 catalysed azidolysis of epoxides with high regioselectivity and low to moderate (S)-enantioselectivity (E?=?1–16). Mutation of the asparagine 178 to alanine (N178A) showed increased enantioselectivity towards styrene oxide derivatives and glycidyl ethers. Conversion of aromatic epoxides was catalysed by HheA-N178A with complete enantioselectivity, however the regioselectivity was reduced. As a result of the enzyme-catalysed reaction, enantiomerically pure (S)-β-azido alcohols and (R)-α-azido alcohols (ee???99%) were obtained.