39267-04-4

Basic information

• Product Name: 2,3-Dichloro-6-methoxyquinoxaline
• Synonyms: Quinoxaline, 2,3-dichloro-6-Methoxy-;2,3-Dichloro-6-methoxy-1,4-benzodiazine;Grazoprevir Intermediate 1;EOS-61016
• CAS NO: 39267-04-4
• Molecular Formula: C₉H₆Cl₂N₂O
• Molecular Weight: 229.06
• Product Categories: intermediates
• Mol File: 39267-04-4.mol
• Article Data: 23

Chemical Properties

• Boiling Point: 312.6 °C at 760 mmHg
• Flash Point: 142.9 °C
• Appearance: /
• Density: 1.450
• Vapor Pressure: 0.00096mmHg at 25°C
• Refractive Index: 1.637
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 2,3-Dichloro-6-methoxyquinoxaline(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-Dichloro-6-methoxyquinoxaline(39267-04-4)
• EPA Substance Registry System: 2,3-Dichloro-6-methoxyquinoxaline(39267-04-4)

Safety Data

• Hazardous Substances Data: 39267-04-4(Hazardous Substances Data)

Usage

Uses

2,3-Dichloro-6-methoxyquinoxaline is used for preparation of antibacterial and antifungal activity of (tetrazolo[1,5-a]quinoxalinyl)dihydrophthalazine-diones as reactant or reagent.

InChI:InChI=1/C9H6Cl2N2O/c1-14-5-2-3-6-7(4-5)13-9(11)8(10)12-6/h2-4H,1H3

Upstream product

• 67-56-1 methanol 
• 31910-18-6 2,3-dioxo-6-methoxy-1,2,3,4-tetrahydroquinoxaline 
• 102-69-2 tri-n-propylamine 
• 31910-18-6 2,3-dihydroxy-6-methoxyquinoxaline 
• 59548-39-9 4-methoxyphenylene-1,2-diamine dihydrochloride 
• 91192-32-4 6-methoxyquinoxalin-2-ol 
• 55687-30-4 7-methoxyquinoxalin-2-ol 
• 102-51-2 4-methoxy-1,2-phenylenediamine 
• 924-44-7 glyoxylic acid ethyl ester 
• 16133-49-6 5-methoxy-2-nitroaniline 
• 119-81-3 4-methoxy-2-nitroacetanilide 
• 51-66-1 4-methoxyacetanilide 
• 104-94-9 4-methoxy-aniline 
• 96-96-8 4-methoxy-2-nitroaniline 

Downstream Products

• 1261078-47-0 (2E,2'E)-diethyl 3,3'-(((6-methoxyquinoxaline-2,3-diyl)bis(azanediyl))bis(4,1-phenylene))diacrylate 
• 1425038-23-8 methyl (1aR,5S,8S,10R,22aR)-5-tert-butyl-14-methoxy-3,6-dioxo-18,19-didehydro-1,1a,3,4,5,6,9,10,20,21,22,22a-dodecahydro-8H-7,10-methanocyclopropa[18,19][1,10,3, 6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxylate 
• 1361028-94-5 methyl (4R)-4-[(3-chloro-7-methoxyquinoxalin-2-yl)oxy]-L-prolinate hydrochloride 
• 1425038-20-5 (2S,4R)-4-[(3-chloro-7-methoxyquinoxalin-2-yl)oxy]-2-(methoxycarbonyl)pyrrolidin-1-ium methanesulfonate 
• 1206524-81-3 (2S,4R)-methyl 4-((3-chloro-7-methoxyquinoxalin-2-yl)oxy)-1-((S)-3,3-dimethyl-2-((((1R,2R)-2-(pent-4-en-1-yl)cyclopropoxy)carbonyl)amino)butanoyl)pyrrolidine-2-carboxylate 

Relevant articles and documents

Synthesis and vasorelaxant evaluation of novel 7-methoxyl-2,3-disubstituted-quinoxaline derivatives

An array of novel 7-methoxyl-2,3-disubstituted quinoxaline derivatives was designed, synthesized and their potential antihypertensive activities were examined, in an attempt to discover potent small molecules with vasorelaxant effects. The vasoactivities of these compounds on vascular tone, as well as underlying mechanisms were hereby explored. Results showed that five compounds (7s, 7t, 7v, 7w, 7γ) could induce endothelium-independent relaxation in high extracellular K+- and phenylephrine-precontracted C57 mice aortic rings. These five compounds, unlike other commonly used vasodilators, could slowly but effectively inhibit vasoconstriction.

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A One-pot Facile Synthesis of 2,3-Dihydroxyquinoxaline and 2,3-Dichloroquinoxaline Derivatives Using Silica Gel as an Efficient Catalyst

An efficient one-pot reaction has been developed for the synthesis of 2,3-dichloroquinoxaline derivatives 3a–n. The reaction was performed in two steps via a silica gel catalyzed tandem process from o-phenylenediamine and oxalic acid, followed by addition of phosphorus oxychloride (POCl3). A variety of 2,3-dichloroquinoxalines have been obtained in good to excellent overall yields. Eight known compounds 3a–3h were characterized by IR, 1H-NMR, and mass spectroscopies. Compounds 3i–3n without spectroscopic data were characterized by IR, 1H-NMR, 13C-NMR, and mass spectroscopies.