3988-74-7

Basic information

• Product Name: 2-Propen-1-one, 1-(2-furanyl)-3-phenyl-
• CAS NO: 3988-74-7
• Molecular Formula: C13H10O2
• Molecular Weight: 198.221
• Mol File: 3988-74-7.mol
• Article Data: 79

Chemical Properties

• CAS DataBase Reference: 2-Propen-1-one, 1-(2-furanyl)-3-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propen-1-one, 1-(2-furanyl)-3-phenyl-(3988-74-7)
• EPA Substance Registry System: 2-Propen-1-one, 1-(2-furanyl)-3-phenyl-(3988-74-7)

Safety Data

• Hazardous Substances Data: 3988-74-7(Hazardous Substances Data)

Upstream product

• 141037-91-4 1-(furan-2-yl)-3-hydroxy-3-phenylpropan-1-one 
• 875877-85-3 [[1-(2-furyl)-3-phenyl-2-propynyl]oxy]-trimethylsilane 
• 1192-62-7 1-(2-furyl)-1-ethanone 
• 100-52-7 benzaldehyde 
• 98-01-1 furfural 
• 536-74-3 phenylacetylene 
• 1777-60-2 [(furan-2-ylcarbonyl)methylene]triphenylphosphorane 
• 1467-70-5 furan-2-yl-oxo-acetic acid 
• 140-10-3 (E)-3-phenylacrylic acid 
• 103-49-1 dibenzylamine 
• 326-90-9 4,4,4-trifluoro-1-(2-furanyl)-1,3-butanedione 
• 527-69-5 2-furancarbonyl chloride 
• 6783-05-7 trans-2-phenylvinylboronic acid 
• 2975-99-7 2-furyl phenylethynyl ketone 

Downstream Products

• 143505-06-0 5,6-Dihydro-1,3-dimethyl-7-(2-furyl)-6-<1-phenyl-3-(2-furyl)-3-oxoprop-1-yl>-5-phenyl-pyrido<2,3-d>pyrimidin-2,4-(1H,3H)-dion 
• 127144-01-8 6-Furan-2-yl-4-phenyl-2-thioxo-1,2-dihydro-pyridine-3-carbonitrile 
• 78572-58-4 1-(Furan-2-carbonyl)-2-phenyl-1,2,3,8a-tetrahydro-indolizine-3-carboxylic acid ethyl ester 
• 78572-63-1 1-(Furan-2-carbonyl)-2-phenyl-1,2,3,8a-tetrahydro-indolizine-3-carboxylic acid amide 
• 136786-76-0 1-(3-(furan-2-yl)-4,5-dihydro-5-phenylpyrazol-1-yl)ethanone 
• 78572-77-7 1-(Furan-2-carbonyl)-2-phenyl-1,2,3,10b-tetrahydro-pyrrolo[2,1-a]isoquinoline-3-carboxylic acid amide 
• 136786-82-8 3-Furan-2-yl-1-methyl-5-phenyl-4,5-dihydro-1H-pyrazole 
• 133617-64-8 3-cyano-6-(2-furyl)-2-methyl-4-phenylpyridine 
• 2976-01-4 1-(furan-2-yl)-3-phenylpropan-1-one 
• 136786-64-6 3-Furan-2-yl-5-phenyl-4,5-dihydro-1H-pyrazole 
• 80927-46-4 1,5-Bis(2-furyl)-3-phenylpentan-1,5-dion 
• 83463-03-0 1,5-Di-furan-2-yl-2-methyl-3-phenyl-pentane-1,5-dione 
• 83463-04-1 2-Ethyl-1,5-di-furan-2-yl-3-phenyl-pentane-1,5-dione 
• 148066-37-9 3-hydroxy-5-phenyl-3-(2-furyl)-6-ethoxycarbonylcyclohexanone 

Relevant articles and documents

Domino Synthetic Strategy for Tetrahydrothiopyran Derivatives from Benzaldehydes, 2-Acetylfuran/2-Acetylthiophene, and Sodium Sulfide

A novel domino reaction from benzaldehydes and 2-acetylfuran/2-acetylthiophene with sodium sulfide was developed to synthesize a series of tetrahydrothiopyran (THTP) derivatives. The reaction proceeded well to construct a tetrahydrothiopyran ring and five new bonds in one step. A mechanism is proposed, involving a stepwise Aldol/double Michael addition/Aldol (AMMA) reaction cascade. In this transformation, sodium sulfide acts as a nucleophile and base. This method is characterized by transition-metal-free, commercially available starting materials and mild reaction conditions.

Potassium Base-Promoted Diastereoselective Synthesis of 1,3-Diols from Allylic Alcohols and Aldehydes through a Tandem Allylic-Isomerization/Aldol–Tishchenko Reaction

This study reports the first base-promoted aldol–Tishchenko reactions of allylic alcohols with aldehydes initiated by allylic isomerization. The reaction enables the diastereoselective synthesis of a variety of 1,3-diols with three contiguous stereogenic centers. Unlike commonly reported systems, our method allows the use of readily available allylic alcohols as nucleophiles instead of enolizable aldehydes and ketones.

Enantioselective Stetter Reactions Catalyzed by Bis(amino)cyclopropenylidenes: Important Role for Water as an Additive

The first highly enantioselective intermolecular Stetter reaction using simple enones is reported. A series of novel chiral BAC structures were designed and prepared. They were tested in the Stetter reaction with simple aldehydes and enones. The products were generated in excellent yields and enantioselectivities (up to 94% ee). Surprisingly, a substoichiometric amount of water was crucial to obtain high enantioselectivities. Chiral BACs were also shown to catalyze 1,6-conjugate addition reactions with paraquinone methides enantioselectively.