40073-96-9

Basic information

• Product Name: Formamide, N-[2-(1-methylethenyl)phenyl]-
• CAS NO: 40073-96-9
• Molecular Formula: C10H11NO
• Molecular Weight: 161.203
• Mol File: 40073-96-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Formamide, N-[2-(1-methylethenyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Formamide, N-[2-(1-methylethenyl)phenyl]-(40073-96-9)
• EPA Substance Registry System: Formamide, N-[2-(1-methylethenyl)phenyl]-(40073-96-9)

Safety Data

• Hazardous Substances Data: 40073-96-9(Hazardous Substances Data)

Upstream product

• 64-18-6 formic acid 
• 52562-19-3 2-isopropenylaniline 
• 124-38-9 carbon dioxide 
• 60249-97-0 1-(1-methylethenyl)-2-nitrobenzene 
• 552-89-6 2-nitro-benzaldehyde 
• 2258-42-6 formyl acetic anhydride 
• 551-93-9 2-aminoacetophenone 

Downstream Products

• 4789-76-8 4-methyl-2-phenylquinoline 
• 7117-17-1 N-methyl-2-(1-methylethenyl)benzenamine 
• 607-66-9 4-methyl-1,2-dihydroquinolin-2-one 
• 7654-51-5 2,2′-biquinoline-4,4′-dicarboxylic acid 
• 112158-32-4 1-isocyano-2-(1-methylethenyl)benzene 
• 19155-24-9 3,3-dimethyloxindole 
• 30696-28-7 4-methyl-3,4-dihydroquinolin-2(1H)-one 

Relevant articles and documents

The formation of quinolin-2(1H)-ones via electrocyclic reaction of o-isocyanatostyrenes generated in situ from o-isocyanostyrenes

A convenient one-pot preparation of 4-substituted or 3,4-disubstituted quinolin-2(1H)-ones from 2-isocyanostyrene derivatives, which involves mCPBA oxidation to the corresponding isocyanate intermediates followed by electrocyclization, is described.

Mn(III)-Mediated Regioselective 6-endo-trig Radical Cyclization of o-Vinylaryl Isocyanides to Access 2-Functionalized Quinolines

A Mn(III)-mediated radical cyclization reaction of o-vinylaryl isocyanides and arylboronic acids or diphenylphosphine oxides to access various 2-functionalized quinolines under mild conditions was developed. With the introduction of radical stabilizing substituents (e. g. aryl and methyl group) on vinyl group, this reaction provides a regiospecific 6-endo-trig radical cyclization of o-vinylaryl isocyanides, giving a number of structurally unique and biologically potential 2-functionalized quinoline derivatives.

An Efficient Synthesis of 2,4-Disubstituted Quinolines by Electrophile-Mediated Cyclization Reactions of 2-Isocyanostyrene Derivatives

A novel quinoline synthesis starting with 2-isocyanostyrene derivatives is described. The treatment of 2-isocyanostyrene derivatives with aldehydes (or acetone) in the presence of a catalytic amount of diethyl ether-boron trifluoride afforded quinoline derivatives carrying a 1-hydroxyalkyl substituent at the 2-position. The use of acetaldehyde diethyl acetal or phenyloxirane as an electrophile under the same conditions gave the corresponding quinoline derivatives, carrying the 1-ethoxyethyl or 2-hydroxy-2-phenylethyl substituent at the 2-position, respectively. 2-Isocyanostyrene derivatives reacted with N,N-dimethyliminium salts without any catalyst to give 2-(1-dimethylaminoalkyl)quinolines.