4125-93-3

Basic information

• Product Name: H-ASP-OTBU
• Synonyms: L-Asparticacida-tertutylester;(S)-3-Amino-4-tert-butoxy-4-oxobutanoic acid;H-Asp-OtBu;L-Aspartic acid 1-tert-butyl ester, >=98%;L-Asp-OtBu;L-Aspartic acid α-tert-butyl ester≥ 98% (HPLC);L-Aspartic acid 1-tert-butylester;L-Aspartic acid α-tert·butyl ester
• CAS NO: 4125-93-3
• Molecular Formula: C₈H₁₅NO₄
• Molecular Weight: 189.209
• Product Categories: Amino Acids and Derivatives;Amino Acids Derivatives;Aspartic acid [Asp, D]
• Mol File: 4125-93-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 180-181 °C (decomp)
• Boiling Point: 297.8 °C at 760 mmHg
• Flash Point: 133.9 °C
• Appearance: /
• Density: 1.126 g/cm³
• Vapor Pressure: 0.000316mmHg at 25°C
• Refractive Index: 1.475
• Storage Temp.: Store at 0°C
• Solubility: Methanol (Heated, Sonicated), Water (Slightly)
• PKA: 3.48±0.19(Predicted)
• CAS DataBase Reference: H-ASP-OTBU(CAS DataBase Reference)
• NIST Chemistry Reference: H-ASP-OTBU(4125-93-3)
• EPA Substance Registry System: H-ASP-OTBU(4125-93-3)

Safety Data

• Hazardous Substances Data: 4125-93-3(Hazardous Substances Data)

Usage

Chemical Properties

White powder

InChI:InChI=1/C8H15NO4/c1-8(2,3)13-7(12)5(9)4-6(10)11/h5H,4,9H2,1-3H3,(H,10,11)/t5-/m0/s1

Upstream product

• 540-88-5 acetic acid tert-butyl ester 
• 56-84-8 L-Aspartic acid 
• 129460-09-9 Fmoc-Asp-O-t-Bu 
• 94347-11-2 4-benzyl 1-t-butyl L-aspartate 
• 67-56-1 methanol 
• 485-47-2 indan-1,2,3-trione hydrate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 107-95-9 3-amino propanoic acid 

Downstream Products

• 47307-26-6 (S)-2-benzyloxycarbonylamino-succinic acid 1-tert-butyl ester 
• 1246617-26-4 C₄₃H₆₄N₂O₁₁S 
• 133125-17-4 2(S)-2-(benzyloxycarbonylamino)-4-iodobutyric acid tert-butyl ester 
• 78266-81-6 tert-butyl N-[(benzyloxy)carbonyl]-L-homoserinate 
• 601491-39-8 tert-butyl (2S)-4-bromo-2-(N-benzyloxycarbonyl)aminobutyrate 
• 1246617-30-0 C₆₅H₉₇N₃O₁₆S₂ 
• 86088-19-9 N-<2-(Triphenylphosphonio)ethoxycarbonyl>asparaginsaeure-1-tert-butylester-chlorid 
• 116864-67-6 Noc-Asp(OH)-OtBu 

Relevant articles and documents

Preparation method of aspartic acid-1-tert-butyl ester derivative

The invention relates to a preparation method of an aspartic acid-1-tert-butyl ester derivative and the field of polypeptide synthesis. The preparation method includes following steps: (1), preparing aspartic acid into a mixture of aspartic acid-4-tert-butyl ester and aspartic acid-1-tert-butyl ester; (2), mixing the mixture with salt of transition metal M to obtain a mixture of M[Asp(OtBu)]x and M(Asp-OtBu)x, wherein x is greater than or equal to 1 and less than or equal to 2; (3), enabling the mixture to react with a protection agent, and allowing selective reaction to obtain the aspartic acid-1-tert-butyl ester derivative. The preparation method is few in step, low in cost, high in production time efficiency and easy for industrial mass production.

Ophthalmic liposomes

A liposome composition with enhanced retention on ocular surfaces, for use in ophthalmic drug delivery and dry eye treatment. The liposomes contain about 10-40 mole percent of an amine-derivatized lipid component in which a charged amine group is spaced from a lipid polar head region by a carbon-containing spacer arm at least 3 atoms in length. The liposomes preferably have a close packed lipid structure produced by inclusion of between 20-50 mole percent of cholesterol or an amine-derivatized cholesterol, and/or phospholipids with predominantly saturated acyl chain moieties. The liposomes may be suspended in an aqueous medium containing a high-viscosity polymer, formulated in paste form, or embedded in a polymer matrix, to enhance further the retention of liposomes on a corneal surface.