441351-41-3

Basic information

• Product Name: 4'-(tert-butyldimethylsilyloxy)-3,5-dimethoxybenzhydrol
• Synonyms: 4'-(tert-butyldimethylsilyloxy)-3,5-dimethoxybenzhydrol
• CAS NO: 441351-41-3
• Molecular Weight: 374.552
• Mol File: 441351-41-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4'-(tert-butyldimethylsilyloxy)-3,5-dimethoxybenzhydrol(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-(tert-butyldimethylsilyloxy)-3,5-dimethoxybenzhydrol(441351-41-3)
• EPA Substance Registry System: 4'-(tert-butyldimethylsilyloxy)-3,5-dimethoxybenzhydrol(441351-41-3)

Safety Data

• Hazardous Substances Data: 441351-41-3(Hazardous Substances Data)

Upstream product

• 106-41-2 4-bromo-phenol 
• 67963-68-2 t-butyldimethylsilyl-4-bromophenol 
• 7311-34-4 3,5-dimethoxybenzaldehdye 

Downstream Products

• 441351-43-5 4'-(tert-butyldimethylsilyloxy)-3,5-dimethoxybenzophenone 

Relevant articles and documents

Antineoplastic agents. 465. Structural modification of resveratrol: Sodium resverastatin phosphate

As an extension of structure/activity investigations of resveratrol (1), phenstatin (2c), and the cancer antiangiogenesis drug sodium combretastatin A-4 phosphate (2b), syntheses of certain related stilbenes (14) and benzophenones (16) were undertaken. The trimethyl ether derivative of (Z)-resveratrol (4a) exhibited the strongest activity (GI50 = 0.01-0.001 μg/mL) against a minipanel of human cancer cell lines. A monodemethylated derivative (14c) was converted to prodrug 14n (sodium resverastatin phosphate) for further biological evaluation. The antitubulin and antimicrobial activities of selected compounds were also evaluated.