4415-82-1

Basic information

• Product Name: Cyclobutanemethanol
• Synonyms: (HYDROXYMETHYL)CYCLOBUTANE;cyclobutylcarbinol;CYCLOBUTYLMETHANOL;CYCLOBUTANECARBINOL;CYCLOBUTANEMETHANOL;RARECHEM AK ML 0579;Cyclobutylcarbinol~Hydroxymethylcyclobutane;Cyclobutanemethanol,99%
• CAS NO: 4415-82-1
• Molecular Formula: C₅H₁₀O
• Molecular Weight: 86.13
• EINECS: 224-575-4
• Product Categories: API intermediates;Cyclobutanes & Cyclobutenes;Simple 4-Membered Ring Compounds;Cycloalkanes;Alcohols;C2 to C6;Oxygen Compounds;Benazir bhutto, Nadine brown brown, analgesic, such as intermediates.
• Mol File: 4415-82-1.mol
• Article Data: 25

Chemical Properties

• Melting Point: 68.5 °C
• Boiling Point: 143-144 °C(lit.)
• Flash Point: 104 °F
• Appearance: Clear colorless/Liquid
• Density: 0.913 g/mL at 25 °C(lit.)
• Vapor Pressure: 2.14mmHg at 25°C
• Refractive Index: n20/D 1.446(lit.)
• Storage Temp.: Flammables area
• PKA: 15.26±0.10(Predicted)
• Water Solubility: immiscible
• BRN: 2036027
• CAS DataBase Reference: Cyclobutanemethanol(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclobutanemethanol(4415-82-1)
• EPA Substance Registry System: Cyclobutanemethanol(4415-82-1)

Safety Data

• Hazard Codes: R10:易燃
• Statements: 10
• Safety Statements: 16-24/25
• RIDADR: UN 1987 3/PG 3
• WGK Germany: 3
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 4415-82-1(Hazardous Substances Data)

Usage

Chemical Properties

Colorless to Almost colorless clear liquid.

Uses

Cyclobutanemethanol was used in the synthesis of bicyclic lactone.

Application

Cyclobutanemethanol is a drug used to treat inflammatory diseases. It is an uptake inhibitor that blocks the transport of uridine into cells, preventing the activation of G-protein coupled receptors and the subsequent production of inflammatory mediators. Cyclobutanemethanol has been shown to have anti-inflammatory properties by inhibiting the CB2 receptor, which is found in large quantities in inflammatory tissues. It also prevents dehydration and increases blood flow to inflamed areas by acting on vascular endothelial cells. It has been shown to inhibit influenza virus replication in vitro, but not in vivo.

General Description

Oxidation of cyclobutanemethanol in the presence of lead tetraacetate and lead tetraacetate/metal chloride has been investigated.

Synthesis

Cyclobutanemethanol can be synthesized from two molecules of hydrochloric acid and one molecule of cyclobutane. The synthesis pathway includes removal of a hydroxy group and addition of an alkynyl group via hydrogen bonding interactions with chloride ions.

InChI:InChI=1/C5H10O/c6-4-5-2-1-3-5/h5-6H,1-4H2

Synthetic route

C8H18OSi → cyclobutanemethanol (4415-82-1)

Conditions	Yield
With methanol; 1,3-disulfonic acid imidazolium hydrogen sulfate at 20℃; for 0.0666667h; Green chemistry;	98%

Cyclobutanecarboxylic acid (3721-95-7) → cyclobutanemethanol (4415-82-1)

Conditions	Yield
With lithium aluminium tetrahydride In diethyl ether for 1.5h; Ambient temperature;	96%
With lithium aluminium tetrahydride In diethyl ether	72%
With lithium aluminium tetrahydride; diethyl ether

ethyl cyclobutylcarboxylate (14924-53-9) → cyclobutanemethanol (4415-82-1)

Conditions	Yield
With lithium aluminium tetrahydride In diethyl ether 1) rt, 24 h, 2) reflux, 1.5 h;	53%
With ethanol; sodium
Stage #1: ethyl cyclobutylcarboxylate With diethoxymethylane; zinc diacetate In toluene at 100℃; for 24h; Inert atmosphere; Stage #2: With methanol; potassium hydroxide chemoselective reaction;	65 %Chromat.

ethanol (64-17-5) + diethyl cyclobutane-1,1-dicarboxylate (3779-29-1) → cyclobutanemethanol (4415-82-1)

Conditions	Yield
With sodium; toluene

diethyl cyclobutane-1,1-dicarboxylate (3779-29-1) → [1-(hydroxymethyl)cyclobutyl]methanol (4415-73-0) + cyclobutanemethanol (4415-82-1)

Conditions	Yield
With ethanol; sodium
With ethanol; sodium Erwaermen des Reaktionsgemisches auf 130-140grad;

(1-cyclobutenyl)methyl alcohol (89182-08-1) → cyclobutanemethanol (4415-82-1)

Conditions	Yield
With methanol; platinum Hydrogenation;

Cyclobutanecarbonyl chloride (5006-22-4) → cyclobutanemethanol (4415-82-1)

Conditions	Yield
With diethyl ether; sodium
With lithium aluminium tetrahydride In diethyl ether for 2h; Heating; Yield given;

methylidenecyclobutane (1120-56-5) → cyclobutanemethanol (4415-82-1)

Conditions	Yield
(i) B2H6, THF, (ii) H2O2; Multistep reaction;

cyclobutylaldehyde (2987-17-9) → cyclobutanemethanol (4415-82-1)

Conditions	Yield
With sodium hydroxide at 80℃; for 42h;

3-(hydroxymethyl)cyclobutene (15963-49-2) → cyclobutanemethanol (4415-82-1)

Conditions	Yield
With hydrogen; platinum(IV) oxide In methanol

5-bromo-1,2-epoxypentane (21746-87-2) → Cyclopentanol (96-41-3) + cyclobutanemethanol (4415-82-1)

Conditions	Yield
With tributylphosphine; copper In tetrahydrofuran Product distribution; other reagent and solvent;
With tributylphosphine; copper In tetrahydrofuran Yield given. Yields of byproduct given;
With copper(l) iodide; lithium dihydronaphthylide radical; triphenylphosphine In tetrahydrofuran 1) -45 deg C, 5 min, -23 deg C, 3 h, r.t.; Yield given. Yields of byproduct given;

methylidenecyclobutane (1120-56-5) → 1 ,5-pentanediol (111-29-5) + cyclobutanemethanol (4415-82-1) + trans-2-methylcyclobutanol

Conditions	Yield
With sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; dihydrogen peroxide 1.) THF, a) RT, 1.5 h, b) 110 deg C, 96 h, 2.) THF, water, 50 deg C to 60 deg C, 1 h; Yield given. Multistep reaction. Yields of byproduct given;
With sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; dihydrogen peroxide 1.) THF, a) RT, 1.5 h, b) 110 deg C, 96 h, 2.) THF, water, 50 deg C to 60 deg C 1 h; Yield given. Multistep reaction. Yields of byproduct given;

cyclobutyl brosylate (51108-24-8) → cyclobutanemethanol (4415-82-1) + p-bromobenzene sulfonic acid (138-36-3)

Conditions	Yield
With sodium methylate In ethanol; water at 45℃; Rate constant;
With sodium acetate In formic acid; acetic acid at 45℃; Rate constant;

2-(3-Iodo-propyl)-oxirane (99700-68-2) → Cyclopentanol (96-41-3) + cyclobutanemethanol (4415-82-1)

Conditions	Yield
With tert.-butyl lithium 1.) Et2O, pentane, -78 deg C, 5 min; 2.) warming; Yield given. Multistep reaction. Yields of byproduct given;
With tert.-butyl lithium In diethyl ether; pentane at -78℃; Product distribution; Effect of various additives or warming.;

diethyl ether (60-29-7) + Cyclobutanecarbonyl chloride (5006-22-4) + sodium → cyclobutanemethanol (4415-82-1)

hydrochloride of aminomethyl-cyclobutane → Cyclopentanol (96-41-3) + cyclobutanemethanol (4415-82-1)

Conditions	Yield
With silver(I) nitrite

ethanol (64-17-5) + diethyl cyclobutane-1,1-dicarboxylate (3779-29-1) + sodium → [1-(hydroxymethyl)cyclobutyl]methanol (4415-73-0) + cyclobutanemethanol (4415-82-1)

sulfuric acid (7664-93-9) + cyclobutylmethyl-cyclobutylmethylen-amine → cyclobutylmethyl cyclobutanecarboxylate (38834-90-1) + cyclobutanemethanol (4415-82-1)

cyclobutylmethylamine hydrochloride (5454-82-0) + AgNO2 → methylidenecyclobutane (1120-56-5) + Cyclopentanol (96-41-3) + cyclobutanemethanol (4415-82-1) + cyclopentene (142-29-0)

Conditions	Yield
man erhitzt die Loesung des erhaltenen Nitrils;

methyl cyclobut-1-enecarboxylate (40628-41-9) → cyclobutanemethanol (4415-82-1) + (1-cyclobutenyl)methyl alcohol (89182-08-1)

Conditions	Yield
With lithium aluminium tetrahydride In diethyl ether at 25℃; for 0.25h; Reduction; Title compound not separated from byproducts.;

1-cyclobutenecarboxylic acid (23519-90-6) → cyclobutanemethanol (4415-82-1)

Conditions	Yield
Multi-step reaction with 2 steps 1: 100 percent / diethyl ether / 0.5 h / 0 °C 2: lithium aluminum hydride / diethyl ether / 0.25 h / 25 °C View Scheme
Multi-step reaction with 2 steps 1: 81 percent / diethyl ether / 48 h / 20 °C 2: lithium aluminum hydride / diethyl ether / 0.25 h / 25 °C View Scheme

diethyl cyclobutane-1,1-dicarboxylate (3779-29-1) → cyclobutanemethanol (4415-82-1)

Conditions	Yield
Multi-step reaction with 3 steps 1: 1.) KOH / 1.) EtOH, H2O; 2.) reflux 2: thionyl chloride 3: lithium aluminum hydride / diethyl ether / 2 h / Heating View Scheme

1-chloro-1-(hydroxymethyl)cyclobutane (81469-29-6) → cyclobutanemethanol (4415-82-1)

Conditions	Yield
Multi-step reaction with 2 steps 1: methanol. KOH-solution 2: platinum; methanol / Hydrogenation View Scheme

3-chlorocyclobutane-1-carboxylic acid (35207-71-7) → cyclobutanemethanol (4415-82-1)

Conditions	Yield
Multi-step reaction with 3 steps 1: (i) Et2O, (ii) LiAlH4 2: KOtBu / dimethylsulfoxide 3: H2 / PtO2 / methanol View Scheme

cyclobutane-1,1-dicarboxylic acid dichloride (51816-01-4) → cyclobutanemethanol (4415-82-1)

Conditions	Yield
Multi-step reaction with 6 steps 1: SO2Cl2, (PhCO)2O2 / 3 h / Heating 2: H2O 3: 12 h / 180 °C 4: (i) Et2O, (ii) LiAlH4 5: KOtBu / dimethylsulfoxide 6: H2 / PtO2 / methanol View Scheme

cyclobutane-1,1'-dicarboxylic acid (5445-51-2) → cyclobutanemethanol (4415-82-1)

Conditions	Yield
Multi-step reaction with 7 steps 1: SOCl2 / 3 h / Heating 2: SO2Cl2, (PhCO)2O2 / 3 h / Heating 3: H2O 4: 12 h / 180 °C 5: (i) Et2O, (ii) LiAlH4 6: KOtBu / dimethylsulfoxide 7: H2 / PtO2 / methanol View Scheme

3-chloro-1,1-cyclobutanedicarboxylic acid (89639-43-0) → cyclobutanemethanol (4415-82-1)

Conditions	Yield
Multi-step reaction with 4 steps 1: 12 h / 180 °C 2: (i) Et2O, (ii) LiAlH4 3: KOtBu / dimethylsulfoxide 4: H2 / PtO2 / methanol View Scheme

3-Chlor-1,1-cyclobutandicarbonsaeure-dichlorid (89582-02-5) → cyclobutanemethanol (4415-82-1)

Conditions	Yield
Multi-step reaction with 5 steps 1: H2O 2: 12 h / 180 °C 3: (i) Et2O, (ii) LiAlH4 4: KOtBu / dimethylsulfoxide 5: H2 / PtO2 / methanol View Scheme

3-chlorocyclobutanemethanol (15963-47-0) → cyclobutanemethanol (4415-82-1)

Conditions	Yield
Multi-step reaction with 2 steps 1: KOtBu / dimethylsulfoxide 2: H2 / PtO2 / methanol View Scheme

cyclobutanemethanol (4415-82-1) + methanesulfonyl chloride (124-63-0) → cyclobutylmethyl methanesulfonate (63659-30-3)

Conditions	Yield
With triethylamine In chloroform at 20℃; for 2h;	100%
With dmap; triethylamine In dichloromethane at 0 - 20℃; for 3h;	66%
With triethylamine In dichloromethane at -10℃; for 0.333333h;

cyclobutanemethanol (4415-82-1) → cyclobutylaldehyde (2987-17-9)

Conditions	Yield
With pyridinium chlorochromate In dichloromethane for 1h; Ambient temperature;	99%
Stage #1: cyclobutanemethanol With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; potassium bromide In dichloromethane; water at -5℃; for 0.333333h; Stage #2: With sodium hypochlorite In dichloromethane; water at -5 - 0℃; for 0.5h; Stage #3: With potassium dihydrogenphosphate In dichloromethane; water at 20℃; for 0.5h;	70.4%
Stage #1: cyclobutanemethanol With oxalyl dichloride; dimethyl sulfoxide In dichloromethane at -78℃; for 1h; Stage #2: With triethylamine In dichloromethane at -78℃;	63%

diethylphosphonoacetic acid (3095-95-2) + cyclobutanemethanol (4415-82-1) → cyclobutylmethyl 2-(diethoxyphosphoryl)acetate

Conditions	Yield
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; ethyl acetate; toluene at 20℃; for 4h; Inert atmosphere;	99%

cyclobutanemethanol (4415-82-1) + trichloroacetonitrile (545-06-2) → cyclobutylmethyl 2,2,2-trichloroacetimidate

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane	99%

4-chlorophenyl acetate (876-27-7) + cyclobutanemethanol (4415-82-1) + 4-acetamidobenzenesulfonyl azide (2158-14-7) → cyclobutylmethyl 2-(4-chlorophenyl)-2-diazoacetate

Conditions	Yield
Stage #1: 4-chlorophenyl acetate; cyclobutanemethanol With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane for 20h; Stage #2: 4-acetamidobenzenesulfonyl azide With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 0℃; for 16h;	99%

phenylglyoxylyl chloride (25726-04-9) + cyclobutanemethanol (4415-82-1) → cyclobutylmethyl 2-oxo-2-phenylacetate

Conditions	Yield
With 1H-imidazole In dichloromethane at 0 - 20℃; Inert atmosphere;	98%

cyclobutanemethanol (4415-82-1) + anthranilic acid amide (28144-70-9) → 2-cyclobutylquinazolin-4(3H)-one

Conditions	Yield
With tert.-butylhydroperoxide In dimethyl sulfoxide at 25 - 35℃; for 40h; Irradiation; Green chemistry;	98%
With tert.-butylhydroperoxide at 110℃; for 12h;	74%

cyclobutanemethanol (4415-82-1) + p-toluenesulfonyl chloride (98-59-9) → cyclobutylmethyl 4-methylbenzenesulfonate (13295-53-9)

Conditions	Yield
With dmap In dichloromethane at 0 - 25℃;	97%
In pyridine at 0℃; for 24h;	92%
In pyridine at -15℃;	92%

cyclobutanemethanol (4415-82-1) + 1-cyano-2-methoxynaphthalene (16000-39-8) → 2-(cyclobutylmethoxy)-1-naphthonitrile

Conditions	Yield
With potassium tert-butylate In 1,4-dioxane at 20℃; for 16h; Inert atmosphere; Sealed tube; Glovebox;	96%

cyclobutanemethanol (4415-82-1) + puberulic acid (99-23-0) → C13H14O6

Conditions	Yield
With toluene-4-sulfonic acid at 120℃; for 16h; Sealed tube;	95%

cyclobutanemethanol (4415-82-1) + 1,1,1,3,3,3-hexamethyl-disilazane (999-97-3) → C8H18OSi

Conditions	Yield
With 1,3-disulfonic acid imidazolium hydrogen sulfate In neat (no solvent) at 20℃; for 0.05h; Green chemistry;	94%

2-cyanopyrimidine (14080-23-0) + cyclobutanemethanol (4415-82-1) → 2-(cyclobutylmethoxy)pyrimidine

Conditions	Yield
With caesium carbonate In dimethyl sulfoxide at 80℃; for 5h;	94%

cyclobutanemethanol (4415-82-1) + C25H26ClN3O2 → C30H35N3O3

Conditions	Yield
With sodium hydride In tetrahydrofuran; mineral oil at 20 - 50℃; for 2.5h;	91%

ditungsten hexa-tert-butoxide (57125-20-9) + cyclobutanemethanol (4415-82-1) → W4(OCH2-c-Bu)12(HOCH2-c-Bu) (120853-44-3)

Conditions	Yield
In hexane byproducts: t-C4H9OH; under N2, adding cyclobutylmethanol dropwise to soln. of W2(O-t-Bu)6, room temp., stirring, 2 h; evapn. of volatile components in vac., dissolving in 1,2-dimethoxyethane, cooling to -20°C, 16 h, filtration at 0°C (2nd crop from filtrate); elem. anal.;	90.2%

3-chloropyrazin-2-amine (6863-73-6) + cyclobutanemethanol (4415-82-1) → 3-(cyclobutylmethoxy)pyrazin-2-amine

Conditions	Yield
Stage #1: cyclobutanemethanol With sodium hydride In N,N-dimethyl-formamide at 20℃; for 1h; Stage #2: 3-chloropyrazin-2-amine In N,N-dimethyl-formamide at 100℃; for 20h;	89%

4-methyleneoxetan-2-one (674-82-8) + cyclobutanemethanol (4415-82-1) → cyclobutylmethyl acetoacetate (103785-41-7)

Conditions	Yield
With sodium hydride at 70 - 80℃; for 2h;	88%

cyclobutanemethanol (4415-82-1) + methyl (3S)-3-{[(tert-butoxy)carbonyl]amino}-3-(4-hydroxyphenyl)propanoate (474295-85-7) → methyl (3S)-3-{[(tert-butoxy)carbonyl]amino}-3-[4-(cyclobutylmethoxy)phenyl]propanoate

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 20 - 35℃; Mitsunobu Displacement; Inert atmosphere;	87%

cyclobutanemethanol (4415-82-1) + N-(3-((1S,5S,6S)-3-amino-1-(methoxymethyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4,5-difluorophenyl)-5-chloro-2-pyrazinecarboxamide → N-(3-((1S,5S,6S)-3-amino-1-(methoxymethyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4,5-difluorophenyl)-5-(cyclobutylmethoxy)pyrazine-2-carboxamide

Conditions	Yield
With caesium carbonate In tetrahydrofuran at 50℃; for 2h;	86%

cyclobutanemethanol (4415-82-1) → cyclobutylmethyl sulfamate

Conditions	Yield
With formic acid; isocyanate de chlorosulfonyle; triethylamine In dichloromethane at 0 - 25℃; Schlenk technique; Inert atmosphere;	86%

tert-butyl N-(4-bromo-1,3-thiazol-2-yl)carbamate (944804-88-0) + cyclobutanemethanol (4415-82-1) → tert-butyl (4-bromothiazol-2-yl)(cyclobutylmethyl)carbamate

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 40℃; for 1.5h; Inert atmosphere;	85%

cyclobutanemethanol (4415-82-1) + sodium formate (141-53-7) + cyclohexene (110-83-8) → cyclobutylmethyl cyclohexanecarboxylate

Conditions	Yield
With 2-Hydroxymethylpyridine; dodecacarbonyl-triangulo-triruthenium at 170℃; for 4h;	84%

cyclobutanemethanol (4415-82-1) + Phenyl triflate (17763-67-6) → 1-cyclobutyl-1-phenyl-methanone (5407-98-7)

Conditions	Yield
With 2,2,6,6-tetramethyl-piperidine; bis(1,5-cyclooctadiene)nickel (0); acetone; [2-((diphenylphospino)methyl)-2-methyl-1,3-propanediyl]bis[diphenylphosphine] In toluene at 130℃; for 20h; Inert atmosphere;	84%

cyclobutanemethanol (4415-82-1) + sodium monochloroacetic acid → cyclobutylmethoxyacetic acid (848666-52-4)

Conditions	Yield
Stage #1: cyclobutanemethanol With sodium hydride In tetrahydrofuran at -15 - 25℃; for 1h; Stage #2: sodium monochloroacetic acid In dimethyl sulfoxide at 20℃; for 20h; Stage #3: With hydrogenchloride In water	83%
Stage #1: cyclobutanemethanol With sodium hydride In tetrahydrofuran at -15 - 25℃; for 1h; pH=2; Stage #2: sodium monochloroacetic acid In tetrahydrofuran; dimethyl sulfoxide at 20℃; for 2h;	83%

cyclobutanemethanol (4415-82-1) + methyl cyclohexanethionocarboxylate (91923-30-7) → O-(cyclobutylmethyl) cyclohexanecarbothioate

Conditions	Yield
With sodium hydride at 75 - 80℃; for 0.5h;	83%

cyclobutanemethanol (4415-82-1) + C14H11FO2 → C19H20O3

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide at 60℃; for 12h; Inert atmosphere;	81.5%

cyclobutanemethanol (4415-82-1) → potassium cyclobutanecarboxylate

Conditions	Yield
With C22H36IrNP(1+)*CF3O3S(1-); potassium hydroxide In toluene at 120℃; for 40h;	81%

ethyl diazomethanesulfonate + cyclobutanemethanol (4415-82-1) + ((6-(3,3-bis(trifluoromethyl)-1λ3-benzo[d][1,2]iodaoxol-1(3H)-yl)hex-5-yn-1-yl)oxy)(tertbutyl)diphenylsilane → ethyl 7-((tert-butyldiphenylsilyl)oxy)-1-(cyclobutylmethoxy)hept-2-yne-1-sulfonate

Conditions	Yield
With tetrakis(actonitrile)copper(I) hexafluorophosphate In dichloromethane at 25℃; for 2h; Inert atmosphere; Sealed tube; Microwave irradiation;	81%

cyclobutanemethanol (4415-82-1) + benzoic acid hydrazide (613-94-5) → N′,N′-bis(cyclobutylmethyl)benzohydrazide

Conditions	Yield
With t-butylnitrite; C24H20N2O4Ru; sodium t-butanolate In tert-butyl alcohol at 130℃; for 24h; Schlenk technique; Inert atmosphere;	81%

Upstream product

• 64-17-5 ethanol 
• 3779-29-1 diethyl cyclobutane-1,1-dicarboxylate 
• 14924-53-9 ethyl cyclobutylcarboxylate 
• 5006-22-4 Cyclobutanecarbonyl chloride 
• 1120-56-5 methylidenecyclobutane 
• 60-29-7 diethyl ether 
• 7664-93-9 sulfuric acid 
• 40628-41-9 methyl cyclobut-1-enecarboxylate 
• 15963-47-0 3-chlorocyclobutanemethanol 
• 3721-95-7 Cyclobutanecarboxylic acid 
• 89582-02-5 3-Chlor-1,1-cyclobutandicarbonsaeure-dichlorid 
• 89639-43-0 3-chlorocyclobutane-1,1-dicarboxylic acid 
• 5445-51-2 cyclobutane-1,1'-dicarboxylic acid 
• 51816-01-4 cyclobutane-1,1-dicarboxylic acid dichloride 

Downstream Products

• 17247-58-4 (Bromomethyl)cyclobutane 
• 137-43-9 Cyclopentyl bromide 
• 287-23-0 cyclobutane 
• 96-41-3 Cyclopentanol 
• 1556-18-9 cyclopentyl iodide 
• 16408-62-1 cyclobutylmethyl iodide 
• 142-29-0 cyclopentene 
• 40015-60-9 Essigsaeure-cyclobutylmethylester 
• 700-88-9 cyclopentylbenzene 
• 108007-96-1 4-<(cyclobutylmethoxy)methyl>-1-(phenylmethoxy)benzene 
• 69563-27-5 Cyclobutylmethylsulfanyl-benzene 
• 191664-01-4 4-Chloro-benzenesulfonic acid cyclobutylmethyl ester 
• 191664-02-5 4-Nitro-benzenesulfonic acid cyclobutylmethyl ester 
• 110-15-6 succinic acid 

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