4890-63-5

Basic information

• Product Name: PHENYLACETYLENEMAGNESIUM CHLORIDE
• Synonyms: PHENYLACETYLENEMAGNESIUM CHLORIDE
• CAS NO: 4890-63-5
• Molecular Formula: C₈H₅ClMg
• Molecular Weight: 160.88
• Mol File: 4890-63-5.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: PHENYLACETYLENEMAGNESIUM CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: PHENYLACETYLENEMAGNESIUM CHLORIDE(4890-63-5)
• EPA Substance Registry System: PHENYLACETYLENEMAGNESIUM CHLORIDE(4890-63-5)

Safety Data

• Hazardous Substances Data: 4890-63-5(Hazardous Substances Data)

Usage

General Description

Phenylacetylenemagnesium chloride is a chemical compound with the formula C8H7MgCl. It is a reagent used in organic synthesis as a source of the phenylacetylide anion, which can be used in reactions such as nucleophilic addition and alkylation. PHENYLACETYLENEMAGNESIUM CHLORIDE is commonly prepared by treating phenylacetylene with magnesium chloride in anhydrous conditions. It is an important intermediate in the synthesis of various organic compounds and is widely used in the pharmaceutical and agrochemical industries. Additionally, phenylacetylenemagnesium chloride has been studied for its potential applications in the development of new materials and pharmaceuticals due to its versatile reactivity and stability.

Upstream product

• 536-74-3 phenylacetylene 

Downstream Products

• 108759-04-2 1,1-Dichlor-3-ethoxy-5-phenyl-penten-⁽¹⁾-in-⁽⁴⁾ 
• 886-66-8 1,4-diphenyl-1,3-butadiyne 
• 77839-87-3 Ge(((C₈H₄N)N)2((C₅H₃N)N)2)(CC(C₆H₅))2 
• 83218-78-4 trans-Bis(phenylethinyl)[tetrakis(trimethylsilyl)phthalocyaninato]germanium 
• 83218-75-1 trans-Bis(phenylethinyl)(tetra-tert-butylphthalocyaninato)germanium 
• 602318-71-8 PtSi(C₆H₄CH₃)3(P(CH₃)2C₆H₅)2CCC₆H₅ 
• 601520-01-8 PtSi(C₆H₄OCH₃)3(P(CH₃)2C₆H₅)2CCC₆H₅ 
• 601520-03-0 PtSi(C₆H₄CF₃)3(P(CH₃)2C₆H₅)2CCC₆H₅ 
• 4341-02-0 biphenyl-2,2'-dicarbonitrile 
• 32183-76-9 2-(phenylethynyl)benzonitrile 
• 7380-78-1 4-(phenylethynyl)anisole 
• 2132-80-1 4,4'-Dimethoxybiphenyl 
• 604-53-5 1,1'-bisnaphthalene 
• 4044-57-9 1-phenylethynyl-naphthalene 

Relevant articles and documents

Regioselective 1,4-conjugate addition of grignard reagents to nitrodienes in the presence of catalytic amounts of Zn(II) salts

Grignard reagents undergo facile regioselective 1,4-conjugate addition to nitrodienes in the presence of catalytic amounts of Zn(II) salts with excellent yields. A wide range of ligands such as alkyl, aryl, heteroaryl, allyl, vinyl, 1-alkynyl, and alkoxy ligands were transferred, while a thiolate ligand afforded 1,6-regioselectivity. The reactions were successfully carried out on δ-alkyl- or aryl-substituted α,β,γ,δ-diunsaturated nitrodiene substrates. Regioselectivity is minimally influenced by temperature or choice of solvent.

S1P RECEPTORS MODULATORS AND THEIR USE THEREOF

The invention relates to novel compounds that have S1P receptor modulating activity. Further, the invention relates to a pharmaceutical comprising at least one compound of the invention for the treatment of diseases and/or conditions caused by or associated with inappropriate S1P receptor modulating activity or expression, for example, autoimmune response. A further aspect of the invention relates to the use of a pharmaceutical comprising at least one compound of the invention for the manufacture of a medicament for the treatment of diseases and/or conditions caused by or associated with inappropriate S1P receptor modulating activity or expression such as autoimmune response.