498-45-3Relevant articles and documents
Kinetic and mechanistic study of Ru(III) catalysed oxidation of anti-cholinergic drug hyoscinebutylbromide by diperiodatocuprate(III) in aqueous alkaline medium
Nayak, Govindrajnaj T.,Havanur, Vidyadhar C.,Harihar, Abdulazizkhan L.
, p. 1 - 9 (2020/03/17)
Hyoscine butyl bromide (HBB) is an anti-cholinergic and anti-muscarinic drug used to treat pain and discomfort caused by abdominal cramps etc. It is semi-synthetic derivative alkaloid hyoscyamine having a broad spectrum of activity. Hence the Ru(III) catalyzed the oxidation of hyoscine butyl bromide drug by diperiodatocuprate(III) (DPC) in aqueous alkaline medium was investigated and monitored spectrophotometrically (λmax = 415 nm) at a constant ionic strength of 0.1 mol dm-3 and 301 K. The reaction shows 1:2 stoichiometry between HBB and DPC. The reaction is of the first order in [DPC] and [Ru(III)] and less than unit order in [HBB] and [alkali], periodate has a retarding effect on the reaction rate. The ionic strength, dielectric constant of the medium and added products has no significant effect on the rate of the reaction but Ru(III) increases the reaction rate. The main oxidation products of HBB were identified by spectral studies. The active forms of catalyst and oxidant were detected as Ru(III), [Cu(H2IO6)(H2O)2] respectively. The rate law and reaction mechanism was proposed. The equilibrium constants and rate constants were calculated. The activation parameters were deliberated for catalyzed and uncatalyzed reactions.
IMPROVED PROCESS FOR ACYL TRANSFER REACTIONS
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Page/Page column 12, (2014/09/29)
The present invention relates to a novel process for the preparation of esters like Aclidinium, Atropin, Glycopyrroniunn, Tiotropium, Trospium and their respective precursors and derivatives, based on direct acyl transfer reactions.
Total synthesis of scopine, pseudoscopine, and nor-derivatives
Justice, David E.,Malpass, John R.
, p. 11977 - 11994 (2007/10/03)
Scopine and pseudoscopine have been synthesised from cyclohepta-3,5-dienol; the initial 1,4-functionalisation of the diene is based on a nitroso- cycloaddition. The use of the N-benzyloxycarbonyl group throughout the scheme allows ultimate reductive deprotection to yield N-methyl or novel NH (nor-) derivatives without damage to the exo-epoxide of the title compounds. Preliminary investigation of nitroso- cycloaddition to 5,6-epoxycyclohepta-1,3-diene is described.