51207-68-2

Basic information

• Product Name: (2S)-N-Cbz-α,α-diMethyl-2-PyrrolidineMethanol
• Synonyms: (2S)-N-Cbz-α,α-diMethyl-2-PyrrolidineMethanol;(2S)-N-Cbz-α,α-dimethyl-2-pyrrolidinemethanol,99%e.e.
• CAS NO: 51207-68-2
• Molecular Formula: C₁₅H₂₁NO₃
• Molecular Weight: 263.33214
• Mol File: 51207-68-2.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2S)-N-Cbz-α,α-diMethyl-2-PyrrolidineMethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-N-Cbz-α,α-diMethyl-2-PyrrolidineMethanol(51207-68-2)
• EPA Substance Registry System: (2S)-N-Cbz-α,α-diMethyl-2-PyrrolidineMethanol(51207-68-2)

Safety Data

• Hazardous Substances Data: 51207-68-2(Hazardous Substances Data)

Usage

General Description

(2S)-N-Cbz-α,α-diMethyl-2-PyrrolidineMethanol, also known as Cbz-proline methyl ester, is a chemical compound that belongs to the class of pyrrolidine derivatives. It is commonly used as a building block in organic synthesis and pharmaceutical research. (2S)-N-Cbz-α,α-diMethyl-2-PyrrolidineMethanol is a protected form of proline, a non-essential amino acid that plays an important role in protein synthesis and is also involved in various metabolic functions. The Cbz protecting group, also known as benzyloxycarbonyl, is commonly used to block the reactivity of certain functional groups during chemical reactions, allowing for selective manipulation of other parts of a molecule. (2S)-N-Cbz-α,α-diMethyl-2-PyrrolidineMethanol is commonly utilized in the synthesis of peptides, pharmaceuticals, and other organic compounds due to its stability and compatibility with various reaction conditions.

Upstream product

• 917-64-6 methyl magnesium iodide 
• 5211-23-4 N-carbobenzyloxy-L-proline methyl ester 
• 74-88-4 methyl iodide 
• 474317-28-7 (S)-2-(1-hydroxy-1-methylethyl)pyrrolidine hydrochloride 
• 501-53-1 benzyl chloroformate 
• 1148-11-4 N-Benzyloxycarbonyl-L-proline 
• 147-85-3 L-proline 
• 75315-63-8 N-(benzyloxycarbonyl)succinimide 
• 2577-48-2 methyl (2S)-pyrrolidine carboxylate 

Downstream Products

• 129149-57-1 (S)-N-formyl-2-(1-hydroxy-1-methylethyl)pyrrolidine 
• 118971-00-9 (S)-(-)-2-(1-methoxy-1-methylethyl)-pyrrolidine 
• 90246-49-4 (8S,8aS)-8-hydroxy-8-methyl-6(Z)-<6-oxo-2(R),5-dimethyl-7(R)-(tert-butyldiphenylsiloxy)-4(E)-octenylidene>octahydroindolizidine 
• 90246-44-9 (1S ,7aS)-tetrahydro-1-methyl-1-<6-(benzyloxy)-4(R)-methyl-2-(trimethylsilyl)-2(Z)-hexenyl>-1H,3H-pyrrolo<1,2-c>oxazol-3-one 
• 90246-46-1 (1S,7aS)-1-((Z)-(R)-6-Benzyloxy-4-methyl-2-trimethylsilanyl-hex-2-enyl)-1-methyl-tetrahydro-pyrrolo[1,2-c]oxazole 
• 90246-45-0 (8S,8aS)-8-hydroxy-8-methyl-6(Z)-<4-(benzyloxy)-2(R)-methylbutylidene>octahydroindolizidine 
• 67016-65-3 Pumiliotoxin B 
• 77733-66-5 benzyl (S)-2-(2(S)-methyloxiranyl)-1-pyrrolidinecarboxylate 
• 77733-65-4 benzyl (S)-2-(2(R)-methyloxiranyl)-1-pyrrolidinecarboxylate 
• 313485-22-2 Ethyl (S)-4-[(2'S)-N-(benzyloxycarbonyl)pyrrolidin-2'-yl]-4-hydroxypent-2-ynoate 
• 313485-23-3 Ethyl (R)-4-[(2'S)-N-(benzyloxycarbonyl)pyrrolidin-2'-yl]-4-hydroxypent-2-ynoate 
• 111491-98-6 (2S)-2-Acetyl-N-(benzyloxycarbonyl)pyrrolidine 
• 51207-70-6 (2S)-N-Benzyloxycarbony-2-(1'-methylethenyl)pyrrolidine 
• 92053-25-3 (S)-(-)-2-(1-hydroxy-1-methylethyl)-pyrrolidine 

Relevant articles and documents

2-ACYLAMINOTHIAZOLE DERIVATIVE AND SALT THEREOF

[Problem] A compound which is useful as an active ingredient of a pharmaceutical composition for treating storage dysfunctions, voiding dysfunctions, and lower urinary tract diseases is provided. [Means for Solution] The present inventors have found that a thiazole derivative having pyrazine-2-carbonylamino substituted at the 2-position is an excellent muscarinic M3 receptor positive allosteric modulator, and is useful as an agent for preventing and/or treating bladder or urinary tract diseases, related to bladder contraction by a muscarinic M3 receptor, thereby completing the present invention. The 2-acylaminothiazole derivative or a salt thereof of the present invention can be used as an agent for preventing and/or treating bladder or urinary tract diseases, related to bladder contraction by a muscarinic M3 receptor, for example, voiding dysfunctions such as underactive bladder.

2-ACYLAMINOTHIAZOLE DERIVATIVE AND SALT THEREOF

[Problem] A compound which is useful as an active ingredient of a pharmaceutical composition for treating storage dysfunctions, voiding dysfunctions, and lower urinary tract diseases is provided. [Means for Solution] The present inventors have found that a thiazole derivative having pyrazine-2-carbonylamino substituted at the 2-position is an excellent muscarinic M 3 receptor positive allosteric modulator, and is useful as an agent for preventing and/or treating bladder or urinary tract diseases, related to bladder contraction by a muscarinic M 3 receptor, thereby completing the present invention. The 2-acylaminothiazole derivative or a salt thereof of the present invention can be used as an agent for preventing and/or treating bladder or urinary tract diseases, related to bladder contraction by a muscarinic M 3 receptor, for example, voiding dysfunctions such as underactive bladder.

A novel approach to the enantioselective formal synthesis of pumiliotoxin 251D

An efficient enantioselective synthesis of the indolizidine framework 9 of pumiliotoxin 251D in good yield by using a Lewis acid (cat.)-promoted diastereoselective addition of ethyl lithiopropiolate to ketone 7 derived from L-proline as a key step is reported. Hydrogenation of the addition product 8a gave the desired lactam 9. At the same time the 8-epimer of 9 was synthesized for the first time.