5140-03-4

Basic information

• Product Name: 1,4-BENZENEDIETHANOL
• Synonyms: 1,4-BENZENEDIETHANOL;1,4-BIS(2-HYDROXYETHYL)BENZENE;1,4-PHENYLENEDIETHANOL;1,4-Benzenediethanol 1,4-Phenylenediethanol;2,2'-(1,4-Phenylene)bis(ethan-1-ol)
• CAS NO: 5140-03-4
• Molecular Formula: C₁₀H₁₄O₂
• Molecular Weight: 166.22
• Mol File: 5140-03-4.mol
• Article Data: 15

Chemical Properties

• Melting Point: 88 °C
• Boiling Point: 193 °C / 11mmHg
• Flash Point: 150.7oC
• Appearance: /
• Density: 1.107g/cm3
• PKA: 14.58±0.10(Predicted)
• CAS DataBase Reference: 1,4-BENZENEDIETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-BENZENEDIETHANOL(5140-03-4)
• EPA Substance Registry System: 1,4-BENZENEDIETHANOL(5140-03-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• Hazardous Substances Data: 5140-03-4(Hazardous Substances Data)

Usage

General Description

1,4-Benzenediethanol, also known as p-bis(2-hydroxyethyl)phenyl ether, is a compound with the chemical formula C10H14O2. It is a diol molecule containing two hydroxyl groups attached to a benzene ring. This chemical is commonly used as a building block for the synthesis of various organic compounds, including polymers, resins, and plasticizers. It is also utilized as a crosslinking agent in the production of epoxy resins, which are widely employed in adhesives, coatings, and composites. Additionally, 1,4-benzenediethanol has antimicrobial properties and is utilized as a preservative in cosmetics, pharmaceuticals, and personal care products. Due to its diverse applications, this chemical plays an important role in various industrial and commercial processes.

Upstream product

• 95-71-6 2-methylbenzene-1,4-diol 
• 36076-26-3 diethyl 2,2'-(1,4-phenylene)diacetate 
• 105-05-5 1,4-diethylbenzene 
• 589-29-7 p-xylylene glycol 
• 622-75-3 1,4-phenylenediacetonitrile 
• 39246-00-9 p-phenylenediacetaldehyde 
• 36076-25-2 (4-methoxycarbonylmethylphenyl)acetic acid methyl ester 
• 7325-46-4 1,4-phenylenediacetic acid 

Downstream Products

• 105-06-6 1,4-Divinylbenzene 
• 4542-72-7 1,4-bis-(2-bromoethyl)benzene 
• 7379-84-2 1,4-bis(2-chloroethyl)benzene 
• 118174-91-7 1,4-bis-(2-ethoxycarbonyloxy-ethyl)-benzene 
• 94112-70-6 1,4-bis-(2-acetoxy-ethyl)-benzene 
• 157860-90-7 1,4-Bis<2-(trifluormethylsulfonyloxy)ethyl>benzol 
• 39246-00-9 p-phenylenediacetaldehyde 
• 888721-96-8 4,4'-(1,4-phenylene)bis[2-(methylthio)butanal] 
• 888721-99-1 4,4'-(1,4-phenylene)bis[2-(dimethylsulfanylidene)butanal] 
• 130800-03-2 2,2'-(1,4-phenylene)diethyl diiodide 
• 874338-61-1 1-phenyl-4-[4-(2-hydroxy-4-phenyl-3-butynyl)phenyl]but-3-yn-2-ol 
• 78965-35-2 2,5-dibromo-1,4-bis(2-bromoethyl)benzene 
• 53-70-3 dibenzo[a,h]anthracene 
• 130800-13-4 C₂₂H₃₀O₂ 

Relevant articles and documents

FUNCTIONALIZED LONG-CHAIN HYDROCARBON MONO- AND DI-CARBOXYLIC ACIDS AND THEIR USE FOR THE PREVENTION OR TREATMENT OF DISEASE

This invention provides compounds of Formulae (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH), (IJ), (IK), (IL), (II), (III), (IIIA), and (IIIB); pharmaceutically acceptable salts and solvates thereof; and compositions thereof. This invention further provides methods for treating a disease, including but not limited to, liver disease or an abnormal liver condition; cancer (such as hepatocellular carcinoma or cholangiocarcinoma); a malignant or benign tumor of the lung, liver, gall bladder, bile duct or digestive tract; an intra- or extra-hepatic bile duct disease; a disorder of lipoprotein; a lipid-and-metabolic disorder; cirrhosis; fibrosis; a disorder of glucose metabolism; a cardiovascular or related vascular disorder; a disease resulting from steatosis, fibrosis, or cirrhosis; a disease associated with increased inflammation (such as hepatic inflammation or pulmonary inflammation); hepatocyte ballooning; a peroxisome proliferator activated receptor-associated disorder; an ATP citrate lyase disorder; an acetyl-coenzyme A carboxylase disorder; obesity; pancreatitis; or renal disease.

SULFONAMIDE DERIVATIVES AND USES THEREOF

The present disclosure relates to compounds of Formula (I) or (II): and to their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inflammatory, autoinflammatory and autoimmune diseases and cancers.

Iron-Catalyzed β-Alkylation of Alcohols

β-Branched alkylated alcohols have been prepared in good yields using a double-hydrogen autotransfer strategy in the presence of our diaminocyclopentadienone iron tricarbonyl complex Fe1. The alkylation of some 2-arylethanol derivatives was successfully addressed with benzylic alcohols and methanol as alkylating reagents under mild conditions. Deuterium labeling experiments suggested that both alcohols (2-arylethanol and either methanol or benzyl alcohol) served as hydrogen donors in this cascade process.