5173-46-6Relevant articles and documents
- 4, 9 - Diene - 3, 17 - dione female ol the preparation method of the (by machine translation)
-
Paragraph 0131; 0142-0146; 0159-0163; 0176-0180; 0193-0197, (2019/02/13)
The invention provides a female neurosteroidogenesis - 4, 9 - diene - 3, 17 - dione of preparation method, the method comprising: in order to have the general formula I compound as the reaction raw material, to said reaction raw materials are mixed anhydride, Grignard reaction, ring-closing reaction, hydrolysis and ring-closing reaction, to obtain the compound having the structural formula V of; the compound has the formula V of the synthetic route of the are as follows: The embodiment of the invention provides a female steroid - 4, 9 - diene - 3, 17 - dione has the simple operation steps in the synthesis process, the raw materials, organic solvent consumption is small, after treatment is easy and easy to enlarge production and the like. (by machine translation)
Preparation method of estra-4,9-diene-3,17-dione
-
, (2018/05/30)
The invention relates to the technical field of processing pharmaceutical intermediates, and particularly relates to a preparation method of estra-4,9-diene-3,17-dione. The method comprises the following steps: (1) carbonyl reduction reaction; (2) hydroxyl protection reaction; (3) substitution reaction; (4) double bond reduction reaction; (5) ketal hydrolysis reaction; (6) cyclization reaction; (7) substitution reaction; (8) ketal hydrolysis reaction; (9) cyclization reaction; (10) hydroxyl deprotection reaction; and (11) hydroxyl oxidation reaction. Reagents used in the method are light in environmental pollution and meet requirements of green chemistry; required raw materials are simple, and easily available and can facilitate industrial production; and the route is simple, the operationis easy, and the control is easy.
METHOD FOR PREPARING 4-[17β-METHOXY-17α-METHOXYMETHYL-3-OXOESTRA-4,9-DIEN-11β-YL]BENZALDEHYDE (E)-OXIME (ASOPRISNIL)
-
Page/Page column 17-18; Sheet 2/3, (2008/06/13)
The present invention relates to a method for the reliable and reproducible preparation of 4-[17β-methoxy-17α-methoxymethyl-3-oxoestra-4,9-dien-llβ- yl]benzaldehyde (E)-oxime (asoprisnil) on the pilot and manufacturing scale. Asoprisnil, which is prepared by this method, is distinguished by a very good physical stability and is therefore particularly suitable for the manufacture of solid pharmaceutical forms (tablets, coated tablets, etc.).