5339-05-9

Basic information

• Product Name: N,N-dimethyl-2-(4-nitrophenyl)ethanamine
• CAS NO: 5339-05-9
• Molecular Formula: C₁₀H₁₄N₂O₂
• Molecular Weight: 194.2304
• Mol File: 5339-05-9.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 301.8°C at 760 mmHg
• Flash Point: 136.3°C
• Density: 1.113g/cm³
• Vapor Pressure: 0.00103mmHg at 25°C
• Refractive Index: 1.547
• CAS DataBase Reference: N,N-dimethyl-2-(4-nitrophenyl)ethanamine(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-dimethyl-2-(4-nitrophenyl)ethanamine(5339-05-9)
• EPA Substance Registry System: N,N-dimethyl-2-(4-nitrophenyl)ethanamine(5339-05-9)

Safety Data

• Hazardous Substances Data: 5339-05-9(Hazardous Substances Data)

Upstream product

• 100-13-0 4-nitrostyrene 
• 124-40-3 dimethyl amine 
• 1126-71-2 N,N-dimethylphenethylamine 
• 937-31-5 (4-Nitrophenyl)acetylene 
• 506-59-2 N,N-dimethylammonium chloride 
• 18182-40-6 N-(trimethylsilylmethyl)dimethylamine 
• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 7697-37-2 nitric acid 
• 5339-26-4 (4-nitrophenyl)ethyl bromide 
• 104-03-0 4-nitrobenzeneacetic acid 
• 555-16-8 4-nitrobenzaldehdye 
• 90405-67-7 N,N-dimethyl-2-(4-nitrophenyl)acetamide 
• 51738-10-4 2,2-dibromo-1-(4-nitrophenyl)ethene 
• 50-00-0 formaldehyd 

Downstream Products

• 7101-10-2 (2-(p-nitrophenyl)ethyl)trimethylammonium iodide 
• 14352-78-4 Dimethyl-<2-p-tolyl-aethyl>-<3-chlor-buten-(2)-yl>-ammoniumchlorid 
• 100-13-0 4-nitrostyrene 
• 1126-71-2 N,N-dimethylphenethylamine 
• 62-23-7 4-nitro-benzoic acid 
• 100880-15-7 {4-[bis-(2-chloro-ethyl)-amino]-phenethyl}-dimethyl-amine 
• 539-15-1 N,N-dimethyltyramine 
• 14352-88-6 Dimethyl-<3-methyl-buten-(2)-yl>-<2-(4-nitro-phenyl)aethyl>-ammoniumchlorid 
• 14352-84-2 Dimethyl-<3-methyl-buten-(2)-yl>-<2-p-tolyl-aethyl>-ammoniumchlorid 
• 5636-52-2 4-[2-(dimethylamino)ethyl]aniline 

Relevant articles and documents

WEE1 inhibitors as well as preparation and application thereof

The invention relates to WEE1 inhibitors as well as preparation and application thereof. The present invention relates to compounds of formula (I), or pharmaceutically acceptable salts, solvates, polymorphs or isomers thereof, and their use in the preparation of medicaments for the treatment of diseases associated with WEE1 activity.

8-ETHYL-6-(ARYL)PYRIDO [2,3-D]PYRIMIDIN-7(8H) -ONES FOR THE TREATMENT OF NERVOUS SYSTEM DISORDERS AND CANCER

Provided herein are PAK inhibitors and methods of utilizing PAK inhibitors for the treatment of CNS disorders such as neuropsychiatric disorders or neurofibromatosis. Also described herein are methods of utilizing PAK inhibitors for the treatment of cancer.

Synthesis and biological evaluation of new 4β-anilino-4′-O- demethyl-4-desoxypodophyllotoxin derivatives as potential antitumor agents

A series of new 4β-anilino-4′-O-demethyl-4-desoxypodophyllotoxin derivatives were prepared and evaluated for their cytotoxicities against four human cancer cell lines including KB, KB/VCR, A549 and 95D. Most compounds showed better growth-inhibition activities against tested cell lines than that of etoposide (VP-16). Preliminary structure-activity relationships (SARs) were concluded and it indicated that the side chains substituted at 4β position of podophyllotoxin significantly influenced the cytotoxic activity, especially for the drug resistance profile. In vivo studies of compound 26c on highly metastatic human lung cancer xenograft in nude mice showed that it can significantly inhibit tumor growth with administrating by oral route.