90405-67-7

Basic information

• Product Name: N,N-dimethyl-2-(4-nitrophenyl)acetamide
• CAS NO: 90405-67-7
• Molecular Formula: C₁₀H₁₂N₂O₃
• Molecular Weight: 208.2139
• Mol File: 90405-67-7.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 376°C at 760 mmHg
• Flash Point: 181.2°C
• Density: 1.214g/cm³
• Vapor Pressure: 7.45E-06mmHg at 25°C
• Refractive Index: 1.558
• CAS DataBase Reference: N,N-dimethyl-2-(4-nitrophenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-dimethyl-2-(4-nitrophenyl)acetamide(90405-67-7)
• EPA Substance Registry System: N,N-dimethyl-2-(4-nitrophenyl)acetamide(90405-67-7)

Safety Data

• Hazardous Substances Data: 90405-67-7(Hazardous Substances Data)

Upstream product

• 98-95-3 nitrobenzene 
• 175658-07-8 N,N-dimethyl-thioglycolamide 
• 18925-69-4 N,N-dimethyl-2-phenylacetamide 
• 7697-37-2 nitric acid 
• 555-16-8 4-nitrobenzaldehdye 
• 104-03-0 4-nitrobenzeneacetic acid 
• 51738-10-4 2,2-dibromo-1-(4-nitrophenyl)ethene 
• 124-40-3 dimethyl amine 
• 15722-62-0 N-Methyl-sarkosin-trimethylamid-Kation 
• 50434-36-1 4-nitrophenylacetyl chloride 
• 103-80-0 phenylacetyl chloride 

Downstream Products

• 861643-06-3 N,N-dimethyl-2-(4-nitrophenyl)ethanethioamide 
• 5339-05-9 N,N-dimethyl-2-(4-nitrophenyl)ethanamine 
• 539-15-1 N,N-dimethyltyramine 
• 81709-36-6 2-(4-Aminophenyl)N,N-dimethylacetamide 
• 5636-52-2 4-[2-(dimethylamino)ethyl]aniline 

Relevant articles and documents

ANTITUMOR-EFFECT ENHANCER USING PYRAZOLO[3,4-D]PYRIMIDINE COMPOUND

To provide a method for treating cancer using a pyrazolo[3,4-d]pyrimidine compound or a salt thereof. The present invention provides an antitumor agent comprising a pyrazolo[3,4-d]pyrimidine compound of formula (I) wherein X, Y, Z1, Z2/su

Selective Allosteric Antagonists for the G Protein-Coupled Receptor GPRC6A Based on the 2-Phenylindole Privileged Structure Scaffold

G protein-coupled receptors (GPCRs) represent a biological target class of fundamental importance in drug therapy. The GPRC6A receptor is a newly deorphanized class C GPCR that we recently reported for the first allosteric antagonists based on the 2-arylindole privileged structure scaffold (e.g., 1-3). Herein, we present the first structure-activity relationship study for the 2-arylindole antagonist 3, comprising the design, synthesis, and pharmacological evaluation of a focused library of 3-substituted 2-arylindoles. In a FRET-based inositol monophosphate (IP1) assay we identified compounds 7, 13e, and 34b as antagonists at the GPRC6A receptor in the low micromolar range and show that 7 and 34b display >9-fold selectivity for the GPRC6A receptor over related GPCRs, making 7 and 34b the most potent and selective antagonists for the GPRC6A receptor reported to date.

An efficient method for one-carbon elongation of aryl aldehydes via their dibromoalkene derivatives

Various aryl aldehydes were efficiently converted into one-carbon extended aryl acetamides or aryl acetic acids through the reaction of their dibromoalkene derivatives with pyrrolidine in the presence of water under very mild conditions.