5636-52-2

Basic information

• Product Name: 4-(2-DIMETHYLAMINO-ETHYL)-ANILINE
• Synonyms: 4-(2-DIMETHYLAMINO-ETHYL)-ANILINE;4-N,N-dimethylamino-beta-phenethylamine;4-(2-azanylethyl)-N,N-dimethyl-aniline;Benzeneethanamine,4-amino-N,N-dimethyl-;[2-(4-Aminophenyl)ethyl]dimethylamine
• CAS NO: 5636-52-2
• Molecular Formula: C₁₀H₁₆N₂
• Molecular Weight: 164.25
• Mol File: 5636-52-2.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 275.8°Cat760mmHg
• Flash Point: 108.3°C
• Appearance: /
• Density: 1.002g/cm³
• Vapor Pressure: 0.00499mmHg at 25°C
• Refractive Index: 1.568
• CAS DataBase Reference: 4-(2-DIMETHYLAMINO-ETHYL)-ANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-DIMETHYLAMINO-ETHYL)-ANILINE(5636-52-2)
• EPA Substance Registry System: 4-(2-DIMETHYLAMINO-ETHYL)-ANILINE(5636-52-2)

Safety Data

• Hazardous Substances Data: 5636-52-2(Hazardous Substances Data)

Usage

General Description

4-(2-DIMETHYLAMINO-ETHYL)-ANILINE is a chemical compound with the molecular formula C11H17N. It is an aniline derivative with a dimethylaminoethyl substituent on the fourth carbon atom. 4-(2-DIMETHYLAMINO-ETHYL)-ANILINE is commonly used as a precursor in the production of dyes, pigments, and other organic compounds due to its reactivity and ability to modify the properties of various materials. It is also utilized in the production of pharmaceuticals, agrochemicals, and in scientific research. However, it is important to handle this chemical with caution as it may pose health and environmental risks if not properly managed.

InChI:InChI=1/C10H16N2/c1-12(2)10-5-3-9(4-6-10)7-8-11/h3-6H,7-8,11H2,1-2H3

Upstream product

• 3544-25-0 p-aminophenylacetonitrile 
• 124-40-3 dimethyl amine 
• 104-03-0 4-nitrobenzeneacetic acid 
• 5339-26-4 (4-nitrophenyl)ethyl bromide 
• 506-59-2 N,N-dimethylammonium chloride 
• 882873-15-6 tert-butyl N-{4-[2-(dimethylamino)-2-oxoethyl]phenyl}carbamate 
• 50434-36-1 4-nitrophenylacetyl chloride 
• 13472-00-9 p-Aminophenethylamine 
• 616-38-6 carbonic acid dimethyl ester 
• 861643-06-3 N,N-dimethyl-2-(4-nitrophenyl)ethanethioamide 
• 81709-36-6 2-(4-Aminophenyl)N,N-dimethylacetamide 
• 5339-05-9 N,N-dimethyl-2-(4-nitrophenyl)ethanamine 
• 90405-67-7 N,N-dimethyl-2-(4-nitrophenyl)acetamide 
• 555-16-8 4-nitrobenzaldehdye 

Downstream Products

• 100880-15-7 {4-[bis-(2-chloro-ethyl)-amino]-phenethyl}-dimethyl-amine 
• 83054-84-6 2,9-Bis-[4-(2-dimethylamino-ethyl)-phenyl]-anthra[2,1,9-def;6,5,10-d'e'f']diisoquinoline-1,3,8,10-tetraone 
• 181822-72-0 2-Benzhydrylsulfanyl-N-[4-(2-dimethylamino-ethyl)-phenyl]-nicotinamide 
• 925242-34-8 C₂₁H₂₀ClFN₆S 
• 1190379-43-1 cyclobutanecarboxylic acid (3-{5-cyclopropyl-2-[4-(2-dimethylamino-ethyl)-phenylamino]-pyrimidin-4-ylamino}-propyl)-amide 
• 1027356-81-5 C₂₉H₃₁N₅O₃ 

Relevant articles and documents

WEE1 inhibitors as well as preparation and application thereof

The invention relates to WEE1 inhibitors as well as preparation and application thereof. The present invention relates to compounds of formula (I), or pharmaceutically acceptable salts, solvates, polymorphs or isomers thereof, and their use in the preparation of medicaments for the treatment of diseases associated with WEE1 activity.

Development of Potent Pyrazolopyrimidinone-Based WEE1 Inhibitors with Limited Single-Agent Cytotoxicity for Cancer Therapy

WEE1 kinase regulates the G2/M cell-cycle checkpoint, a critical mechanism for DNA repair in cancer cells that can confer resistance to DNA-damaging agents. We previously reported a series of pyrazolopyrimidinones based on AZD1775, a known WEE1 inhibitor, as an initial investigation into the structural requirements for WEE1 inhibition. Our lead inhibitor demonstrated WEE1 inhibition in the same nanomolar range as AZD1775, and potentiated the effects of cisplatin in medulloblastoma cells, but had reduced single-agent cytotoxicity. These results prompted the development of a more comprehensive series of WEE1 inhibitors. Herein we report a series of pyrazolopyrimidinones and identify a more potent WEE1 inhibitor than AZD1775 and additional compounds that demonstrate that WEE1 inhibition can be achieved with reduced single-agent cytotoxicity. These studies support that WEE1 inhibition can be uncoupled from the potent cytotoxic effects observed with AZD1775, and this may have important ramifications in the clinical setting where WEE1 inhibitors are used as chemosensitizers for DNA-targeted chemotherapy.

Synthesis and biological evaluation of new 4β-anilino-4′-O- demethyl-4-desoxypodophyllotoxin derivatives as potential antitumor agents

A series of new 4β-anilino-4′-O-demethyl-4-desoxypodophyllotoxin derivatives were prepared and evaluated for their cytotoxicities against four human cancer cell lines including KB, KB/VCR, A549 and 95D. Most compounds showed better growth-inhibition activities against tested cell lines than that of etoposide (VP-16). Preliminary structure-activity relationships (SARs) were concluded and it indicated that the side chains substituted at 4β position of podophyllotoxin significantly influenced the cytotoxic activity, especially for the drug resistance profile. In vivo studies of compound 26c on highly metastatic human lung cancer xenograft in nude mice showed that it can significantly inhibit tumor growth with administrating by oral route.