59663-63-7

Basic information

• Product Name: 2-(2-methylphenyl)-5-phenyl-1,3,4-oxadiazole
• Synonyms: 1,3,4-Oxadiazole, 2-(2-methylphenyl)-5-phenyl-
• CAS NO: 59663-63-7
• Molecular Formula: C₁₅H₁₂N₂O
• Molecular Weight: 236.2686
• Mol File: 59663-63-7.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 395°C at 760 mmHg
• Flash Point: 190.4°C
• Density: 1.149g/cm³
• Vapor Pressure: 4.33E-06mmHg at 25°C
• Refractive Index: 1.583
• CAS DataBase Reference: 2-(2-methylphenyl)-5-phenyl-1,3,4-oxadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-methylphenyl)-5-phenyl-1,3,4-oxadiazole(59663-63-7)
• EPA Substance Registry System: 2-(2-methylphenyl)-5-phenyl-1,3,4-oxadiazole(59663-63-7)

Safety Data

• Hazardous Substances Data: 59663-63-7(Hazardous Substances Data)

Usage

Heterocyclic aromatic compound

It has a ring structure containing both carbon and hetero atoms (nitrogen and oxygen), which gives it aromatic properties.

Contains nitrogen and oxygen atoms

The presence of nitrogen and oxygen atoms in its structure contributes to its unique chemical properties and potential applications.

Potential applications in organic synthesis

The compound may be used as an intermediate or building block in the synthesis of other organic compounds.

Potential applications in medicinal chemistry

Due to its unique structural features, it may be useful in the development of pharmaceutical drugs.

Possible use in materials science

The compound's properties may make it suitable for use in the development of new materials or coatings.

Potential use as a fluorescent dye in biological research

The compound may exhibit fluorescent properties, making it useful as a dye or marker in biological research.

Need for further research and experimentation

The specific uses and properties of 2-(2-methylphenyl)-5-phenyl-1,3,4-oxadiazole would need to be determined through laboratory testing and experimentation.

Upstream product

• 7658-80-2 2-methylbenzohydrazide 
• 611-73-4 Benzoylformic acid 
• 613-94-5 benzoic acid hydrazide 
• 118-90-1 ortho-methylbenzoic acid 
• 18039-42-4 5-Phenyl-1H-tetrazole 
• 529-19-1 2-Methylbenzonitrile 
• 100-47-0 benzonitrile 
• 591-50-4 iodobenzene 
• 67-66-3 chloroform 
• 51449-86-6 5-(2-methylphenyl)-2H-tetrazole 
• 615-37-2 ortho-methylphenyl iodide 
• 18039-42-4 5-phenyl-2H-1,2,3,4-tetrazole 
• 119072-55-8 tert-butylisonitrile 
• 529-20-4 2-methylphenyl aldehyde 

Downstream Products

• 56894-37-2 2-(5-phenyl-1,3,4-oxadiazole-2-yl)-benzoic acid 

Relevant articles and documents

UV-Induced 1,3,4-Oxadiazole Formation from 5-Substituted Tetrazoles and Carboxylic Acids in Flow

A range of 1,3,4-oxadiazoles have been synthesized using a UV-B activated flow approach starting from carboxylic acids and 5-substituted tetrazoles. The application of UV light represents an attractive alternative to the traditional thermolytic approach and has demonstrated comparable efficiency and versatility, with a diverse substrate scope, including the incorporation of highly substituted amino acids.

Photocatalyzed facile synthesis of 2,5-diaryl 1,3,4-oxadiazoles with polyaniline-?g-C3N4-TiO2 composite under visible light

PANI (polyaniline)-g-C3N4-TiO2 composite was prepared and found to be efficient for the synthesis of 2,5-diaryl 1,3,4-oxadiazoles under visible light. This reaction involved decarboxylation and cyclization from α-keto acids with acylhydrazines, and a broad scope of substrates were tolerated to provide the desired products in moderate to good yields. Control experiments indicated that a radical pathway was involved in the present photocatalytic reaction and a synergistic effect may exist in the ternary composite. Moreover, this semiconductor photocatalyst could be readily recovered and showed good reusability with only slight decrease in the catalytic activity after six consecutive runs.

Palladium-catalyzed one-pot synthesis of diazoles via tert-butyl isocyanide insertion

An efficient one-pot palladium-catalyzed reaction for the synthesis of diazoles from readily available hydrazides and aryl halide via isocyanide insertion/cyclization sequence has been developed. This methodology efficiently constructs diazoles in good to excellent yields with the advantages of wide functional group tolerance and operational simplicity.