60846-21-1Relevant articles and documents
Cefotaxime sodium pharmaceutical preparation in the transabdominal or vaginal hysterectomy, gastrointestinal tract and genital tract such as the prevention of infection before the application (by machine translation)
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Paragraph 0138-0140; 0143-0145; 0148-0150; 0171-0174, (2019/11/13)
The present invention provides a head spore sai wowo sodium or its composition, preparation method, preparation and use. The head spore sai wowo sodium or its composition of active ingredients in the Cefotaxime quality content is 98% or more, the impurity content is low, and the safety is high. The present invention provides the preparation method AE - active thioester and 7 - ACA reaction to obtain the spore saisai wo acid; with the spore saisai wo acid generating sodium salt, can get [...]. The preparation method is simple, stable and reliable, production process stability is strong. Therefore, the head spore sai wowo sodium or its composition can be used for pharmaceutical use, particularly for the treatment of transvaginal/abdominal hysterectomy, gastrointestinal, genitourinary tract before and postoperative infection prevention of infection. (by machine translation)
Thioester derivatives of thiazolyl acetic acid and their use in the preparation of cephalosporin compounds
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, (2008/06/13)
The present invention provides new thioester derivatives of thiazolyl acetic acid of the general formula (I), wherein, R1represents H, trityl, CH3, CRaRbCOOR2(Raand Rbindependently of one another represents hydrogen or methyl and R2represents H or C1-C4alkyl). also, the invention provides a method by which the said thioester derivatives can be prepared by reacting thiazolyl acetic acid of the general formula (IV) with 1,2,5,6 tetrahdro-2-methyl-5,6 dioxo-1,2,4-triazin-3-thiol of the formula (VI) in a solvent, in presence of an organic base and with the help of Vilsmeier reagent of the formula (V). The so obtained thioester derivatives are reacted with 7-amino-cephem carboxylic acids of the general formula (III) to produce cephalosporin antibiotic compounds having the general formula (II).
Thioester derivatives of thiazolyl acetic acid and their use in the preparation of cephalosporin compounds
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, (2008/06/13)
The present invention provides novel thioester derivatives of thiazolyl acetic acid of the general formula (I), wherein, R1represents H, trityl, CH3, or CRaRbCOOR3, in which Raand Rb, independently of one another, represents hydrogen or methyl and R3represents H or C1-C7alkyl; and R2represents C1-C4alkyl or phenyl. The invention also provides a method for preparation of the thioester derivatives and reaction of the thioester derivatives with cephem carboxylic acids to produce cephalosporin antibiotic compounds having general formula (II), wherein, R1represents H, trityl, CH3, or CRaRbCOOR3, in which Raand Rb, independently of one another, represents hydrogen or methyl and R3represents H or C1-C7alkyl; R4is CH3, —CH═CH2, CH2OCH3, CH2OCOCH3, and R5is H or a salt or a carboxylic protecting group, comprising, acylating a compound of formula (III), wherein, R4and R5are defined as above, and R6is H or trimethylsilyl; with a compound of formula (I).